Validation of Centers for Disease Control and Prevention level 3 risk classification for healthcare workers exposed to severe acute respiratory coronavirus virus 2 (SARS-CoV-2)

Gragnani, Candace M; Fernandes, Priyanka; Waxman, Daniel A.

doi:10.1017/ice.2020.1353

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…The exposure risk assessment and management system is currently mainly based on expert opinion, because only a few studies have addressed this problem, and there is the significant heterogeneity of operational definitions for variables that influence exposure risk, such as the measurement of contact duration, distance, the use of a face mask versus a respirator with eye protection, and differing vaccine regimens and efficacies [4][5][6][7][8][9]. Further, most COVID-19 healthcare exposure studies categorized exposure risk using multiple measures in combination (without complete details of individual exposure) and were conducted during periods when less contagious variants were circulating and different vaccine products and regimens were employed [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A Risk Prediction Model and Risk Score of SARS-CoV-2 Infection Following Healthcare-Related Exposure

et al. 2022

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Hospital workers are at high risk of contact with COVID-19 patients. Currently, there is no evidence-based, comprehensive risk assessment tool for healthcare-related exposure; so, we aimed to identify independent factors related to COVID-19 infection in hospital workers following workplace exposure(s) and construct a risk prediction model. We analyzed the COVID-19 contact tracing dataset from 15 July to 31 December 2021 using multiple logistic regression analysis, considering exposure details, demographics, and vaccination history. Of 7146 included exposures to confirmed COVID-19 patients, 229 (4.2%) had subsequently tested positive via RT-PCR. Independent risk factors for a positive test were having symptoms (adjusted odds ratio 4.94, 95%CI 3.83–6.39), participating in an unprotected aerosol-generating procedure (aOR 2.87, 1.66–4.96), duration of exposure >15 min (aOR 2.52, 1.82–3.49), personnel who did not wear a mask (aOR 2.49, 1.75–3.54), exposure to aerodigestive secretion (aOR 1.5, 1.03–2.17), index patient not wearing a mask (aOR 1.44, 1.01–2.07), and exposure distance <1 m without eye protection (aOR 1.39, 1.02–1.89). High-potency vaccines and high levels of education protected against infection. A risk model and scoring system with good discrimination power were built. Having symptoms, unprotected exposure, lower education level, and receiving low potency vaccines increased the risk of laboratory-confirmed COVID-19 following healthcare-related exposure events.

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