Validation of Cardiac Surgery-Associated Neutrophil Gelatinase-Associated Lipocalin Score for Prediction of Cardiac Surgery-Associated Acute Kidney Injury

Mostafa, Ezzeldin A.; Shahin, Khaled M.; Midany, Ashraf A.H. El; Hassaballa, Aly Sherif; EL-Sokkary, Ismail Nasr; Gamal, Mohamed; Elsaid, Mohamed E.; ElBarbary, Moustafa G.; Khorshid, Ramy; Elelwany, Shady E.

doi:10.1016/j.hlc.2021.05.084

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…These limitations drive us to search for new biomarkers that detect AKI in an earlier phase. For example, NGAL, a novel discovered biomarker, plays a crucial role in detecting AKI, and it was increased at an earlier stage than the elevation of SCr [2, 15, 16]. NGAL in plasma and urine is increased when acute tubular damage occurs, but pNGAL is detectable earlier than uNGAL.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Cohort Study with 10-Year Follow-Up

Liu¹,

Lv²,

Fei³

et al. 2023

Cardiorenal Med

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Background: The present study aimed to explore the potential effect of ulinastatin on renal function and long-term survival in patients receiving cardiac surgery with CPB. Methods: This prospective cohort study was conducted at Fuwai Hospital, Beijing, China. The ulinastatin was applied after induction anesthesia. The primary outcome was the rate of new-onset postoperative acute kidney injury (AKI). Moreover, a ten-year follow-up was conducted until Jan 2021. Results: The rate of new-onset AKI was significantly lower in the ulinastatin group than in the control group (20.00% vs. 32.40%, p=0.009). There was no significant difference in RRT between the two groups (0.00% vs. 2.16%, p=0.09). The postoperative pNGAL and IL-6 levels were significantly lower in the ulinastatin group compared with the control group(pNGAL: p=0.007; IL-6: p=0.001). A significantly lower incidence of respiratory failure in the ulinastatin group compared with the control group (0.76% vs. 5.40%, p=0.02). The nearly 10-year follow-up(9.37,95CI%:9.17-9.57) survival rates did not differ significantly between the two groups ( p=0.076 ). Conclusions: Ulinastatin significantly reduced postoperative AKI and respiratory failure in patients receiving cardiac surgery with CPB. However, ulinastatin did not reduce ICU and hospital stay, mortality, and long-term survival rate. Key Words: ulinastatin, acute kidney injury, cardiac surgical procedures, cardiopulmonary bypass.

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Section: Discussionmentioning

confidence: 99%

Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Cohort Study with 10-Year Follow-Up

Liu¹,

Lv²,

Fei³

et al. 2023

Cardiorenal Med

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“…Recent studies have demonstrated that plasma LCN2 is elevated in patients with acute myocardial infarction and is associated with poor outcomes like cardiogenic shock or increased risk of mortality [77,78]. As LCN2 levels also positively correlate with kidney disease, it has been proposed as a novel biomarker for cardiac event and as a predictive marker for acute kidney injury following a cardiac surgery [79].…”

Section: Lcn2mentioning

confidence: 99%

Adipose-Derived Lipid-Binding Proteins: The Good, the Bad and the Metabolic Diseases

Frances

Tavernier

Viguerie

2021

IJMS

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Adipose tissue releases a large range of bioactive factors called adipokines, many of which are involved in inflammation, glucose homeostasis and lipid metabolism. Under pathological conditions such as obesity, most of the adipokines are upregulated and considered as deleterious, due to their pro-inflammatory, pro-atherosclerotic or pro-diabetic properties, while only a few are downregulated and would be designated as beneficial adipokines, thanks to their counteracting properties against the onset of comorbidities. This review focuses on six adipose-derived lipid-binding proteins that have emerged as key factors in the development of obesity and diabetes: Retinol binding protein 4 (RBP4), Fatty acid binding protein 4 (FABP4), Apolipoprotein D (APOD), Lipocalin-2 (LCN2), Lipocalin-14 (LCN14) and Apolipoprotein M (APOM). These proteins share structural homology and capacity to bind small hydrophobic molecules but display opposite effects on glucose and lipid metabolism. RBP4 and FABP4 are positively associated with metabolic syndrome, while APOD and LCN2 are ubiquitously expressed proteins with deleterious or beneficial effects, depending on their anatomical site of expression. LCN14 and APOM have been recently identified as adipokines associated with healthy metabolism. Recent findings on these lipid-binding proteins exhibiting detrimental or protective roles in human and murine metabolism and their involvement in metabolic diseases are also discussed.

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Urinary biomarkers associated with acute kidney injury in pediatric mechanical circulatory support patients

et al. 2023

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Validation of Cardiac Surgery-Associated Neutrophil Gelatinase-Associated Lipocalin Score for Prediction of Cardiac Surgery-Associated Acute Kidney Injury

Cited by 4 publications

References 25 publications

Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Cohort Study with 10-Year Follow-Up

Effects of Ulinastatin on Postoperative Renal Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Cohort Study with 10-Year Follow-Up

Adipose-Derived Lipid-Binding Proteins: The Good, the Bad and the Metabolic Diseases

Urinary biomarkers associated with acute kidney injury in pediatric mechanical circulatory support patients

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