“…The anaesthetic and surgical procedures have been described in detail in our previous work. 4 In summary, the pigs were sedated with atropine 0.04 mg kg À1 (Mylan AB, Stockholm, Sweden), tiletamine-zolazepam (Zoletil, Vibrac Laboratories, Carros, France) 6 mg kg À1 , and xylazine chloride (Rompun, Bayer AG, Leverkusen, Germany) 2.2 mg kg À1 administered i.m. Infusion of fentanyl (Fentanyl B. Braun, Melsungen, Germany) 5 mg kg À1 , ketamine 30 mg kg À1 h À1 , midazolam 0.1 mg kg À1 h À1 , and fentanyl 4 mg kg À1 h À1 was used for maintenance of anaesthesia and rocuronium 2 mg kg À1 h À1 for muscle relaxation.…”