Validation of avenanthramide and other phenolic compounds in oats and sprouted oats and their antimicrobial properties against Escherichia coli O157:H7

Lim, SuJi; Yun, Choong-In; Song, Doo-Hoon; Kang, Seong-Gil; Kim, Young‐Jun

doi:10.1007/s10068-022-01099-8

Cited by 4 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total phenolic compound levels are positively correlated with antioxidant activity [38,68,69]. To suppress oxidative stress, ROS-scavenging mechanisms, such as the inhibition of free radical formation and the chelation of metal ions, are required [70,71].…”

Section: Discussionmentioning

confidence: 99%

“…Oats are rich in nutrients and contain avenanthramides, a polyphenol not found in other grains [30]. The contents and activities of avenanthramides and related enzymes in oats were altered by hydration and germination, and sprouted oats have been found to contain more phytochemicals including avenanthramides than typical dried oats [34,[38][39][40][41]. Several studies have reported that avenanthramides exert anti-inflammatory and anti-cancer effects.…”

Section: Introductionmentioning

confidence: 99%

“…Type A avenanthramide also induced cellular senescence by upregulating the expression of miR-129-3p, and avenanthramide C was shown to inhibit COX-2 expression in A549 cells and to induce cellular senescence in CRC cells by attenuating β-catenin-mediated transactivation [43][44][45]. Furthermore, sprouted oats are known to regulate oxidative stress, blood pressure, and low-density lipoprotein cholesterol in blood vessels [34,38,46]. However, the effect of sprouted oats on skin hyperpigmentation due to oxidative damage has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibitory Effects of Fermented Sprouted Oat Extracts on Oxidative Stress and Melanin Overproduction

Cho,

Yang,

Kang

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Hyperpigmentation occurs due to irregular secretion of melanin pigment in the skin. This can affect quality of life depending on its severity, so prevention and management are essential. Oats (Avena sativa L.), a grain consumed worldwide, are known to offer improved health benefits upon germination and fermentation. This study is aimed to investigate the protective effects of lactobacilli-fermented sprouted oat extracts on oxidative stress and melanin overproduction in vitro. The anti-melanogenic effect was investigated using melanin content and tyrosinase activity assays in B16F10 cells, as well as a mushroom tyrosinase-based enzyme inhibition assay. The results showed that L. casei-fermented oat extracts were the most effective for reducing melanin formation by reducing the mRNA expression of microphthalmia-associated transcription factor, tyrosinase, and tyrosinase-related protein 2 mRNA expression. Furthermore, L. casei fermentation was effective in improving the total phenolic, flavonoid, and avenanthramide A contents of sprouted oat extracts. The results also demonstrated the antioxidant effects of L. casei-fermented sprouted oat extracts in promoting DPPH radical-scavenging activity, superoxide dismutase-like activity, and reduction in reactive oxygen species levels. Overall, the findings indicate that fermented sprouted oat extracts are promising candidates for antioxidant and anti-hyperpigmentation treatments.

show abstract