Validation of Assay Indicating Method Development of Simvastatin in Bulk and its Tablet Dosage form by RP-HPLC

Sahoo, Nalini Kanta; Sahu, Madhusmita; Rao, P. Srinivasa; Vineela, R.S.; Devi, J.N.V. Indira; Rani, N.Sandhya; Ghosh, Goutam

doi:10.7324/japs.2014.40120

J Appl Pharm Sci

2014

DOI: 10.7324/japs.2014.40120

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Validation of Assay Indicating Method Development of Simvastatin in Bulk and its Tablet Dosage form by RP-HPLC

Nalini Kanta Sahoo,

Madhusmita Sahu,

P. Srinivasa Rao

et al.

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Cited by 2 publications

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Versatile wetting measurement of microplate wells

Cheong

et al. 2016

Review of Scientific Instruments

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A method to measure the contact angle, which is indicative of wetting, using small liquid volumes dispensed directly on microplate wells is described and demonstrated. Experiments with enhanced green protein samples of volumes 4.4-6 μl showed no measured variance in the contact angle. Experiments with phosphate buffer solution with varied concentrations of a non-ionic detergent (Tween 20) dissolved, however, revealed smaller contact angles with increased detergent concentration. It is experimentally shown that drops can be located up to 7° from the lowest position of the well without affecting the accuracy of contact angle measurements. Numerical simulations confirm the ability of the drops to manifest the correct contact angle despite the lack of axis-symmetry in their shape while residing on a circular surface. This method offers a convenient means to determine the wetting characteristics of different liquid samples in different microplates.

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Versatile wetting measurement of microplate wells

Cheong

et al. 2016

Review of Scientific Instruments

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New stability indicating liquid chromatographic method for the estimation of Valsartan in pharmaceutical dosage forms

Yamani

Annapurna

2023

RJPT

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Valsartan is an orally active antihypertensive agent which belongs to the category of angiotensin II type I receptor antagonists. Valsartan is used for the treatment of heart failure, hypertension, myocardial infraction and diabetic nephropathy. A new stability indicating RP-HPLC was proposed for the quantification of Valsartan by using an ion-pairing agent, tetra butyl ammonium hydrogen sulphate. Mobile phase mixture consisting of 10 mM tetra butyl ammonium hydrogen sulphate and methanol (25: 75, v/v) was selected with a flow rate of 1 ml/min using Agilent C18 column (Detection wavelength 250 nm). The LOD and LOQ were found to be 0.0291 μg/mL and 0.0897 μg/mL respectively. Linearity was observed over the concentration 0.1-50 μg/mL with linear regression equation, y = 36571x + 13532 and the method is precise, accurate and robust. Stress degradation studies were performed and the method was found to be selective and specific.

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Validation of Assay Indicating Method Development of Simvastatin in Bulk and its Tablet Dosage form by RP-HPLC

Cited by 2 publications

References 13 publications

Versatile wetting measurement of microplate wells

Versatile wetting measurement of microplate wells

New stability indicating liquid chromatographic method for the estimation of Valsartan in pharmaceutical dosage forms

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