Validation of an outpatient questionnaire for bronchopulmonary dysplasia control

Collaco, Joseph M.; Li, Yun; Rhein, Lawrence; Tracy, Michael C.; Sheils, Catherine A.; Rice, Jessica L.; Popova, Antonia P.; Moore, Paul; Manimtim, Winston M; Lai, Khanh; Kaslow, Jacob A; Hayden, Lystra P.; Bansal, Manvi; Austin, Eric D.; Aoyama, Brianna C; Alexiou, Stamatia; Agarwal, Amit; Villafranco, Natalie; Siddaiah, Roopa; Lagatta, Joanne; Dawson, Sara; Cristea, A. Ioana; Bauer, Sarah; Baker, Christopher D.; McGrath‐Morrow, Sharon A.

doi:10.1002/ppul.26358

Cited by 3 publications

(2 citation statements)

References 29 publications

(47 reference statements)

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“…Validated instruments were generated by the BPD Collaborative as previously described to collect demographic and clinical data 15,16 . Participant demographics, birth history, and NICU history were collected via questionnaire and chart review at the time of recruitment.…”

Section: Methodsmentioning

confidence: 99%

“…Validated instruments were generated by the BPD Collaborative as previously described to collect demographic and clinical data. 15,16 Participant demographics, birth history, and NICU history were collected via questionnaire and chart review at the time of recruitment. For the primary exposure, subjects were classified by the number of children (<18 years of age) reported to be living in the household at the time of recruitment.…”

Section: Data Collectionmentioning

confidence: 99%

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Number of children in the household influences respiratory morbidities in children with bronchopulmonary dysplasia in the outpatient setting

Collaco,

Tsukahara,

Tracy

et al. 2023

Pediatric Pulmonology

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BackgroundBronchopulmonary dysplasia (BPD), a common complication of prematurity, is associated with outpatient morbidities, including respiratory exacerbations. Daycare attendance is associated with increased rates of acute and chronic morbidities in children with BPD. We sought to determine if additional children in the household conferred similar risks for children with BPD.MethodsThe number of children in the household and clinical outcomes were obtained via validated instruments for 933 subjects recruited from 13 BPD specialty clinics in the United States. Clustered logistic regression models were used to test for associations.ResultsThe mean gestational age of the study population was 26.5 ± 2.2 weeks and most subjects (69.1%) had severe BPD. The mean number of children in households (including the subject) was 2.1 ± 1.3 children. Each additional child in the household was associated with a 13% increased risk for hospital admission, 13% increased risk for antibiotic use for respiratory illnesses, 10% increased risk for coughing/wheezing/shortness of breath, 14% increased risk for nighttime symptoms, and 18% increased risk for rescue medication use. Additional analyses found that the increased risks were most prominent when there were three or more other children in the household.ConclusionsWe observed that additional children in the household were a risk factor for adverse respiratory outcomes. We speculate that secondary person‐to‐person transmission of respiratory viral infections drives this finding. While this risk factor is not easily modified, measures do exist to mitigate this disease burden. Further studies are needed to define best practices for mitigating this risk associated with household viral transmission.

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Section: Methodsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%