Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain

Moriarty, Orla; Roche, Michelle; McGuire, Brian E.; Finn, David P.

doi:10.1016/j.jneumeth.2011.10.024

Cited by 30 publications

(32 citation statements)

References 57 publications

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“…SNL was carried out as described previously (Burke et al, 2013a, Kim and Chung, 1992, Moriarty et al, 2012. Briefly, the rats were anaesthetised with isoflurane (2.5% in 0.6 l/min O 2 ), the fur was clipped, an incision made between the spinal column and the left iliac crest and the paraspinal muscles removed.…”

Section: L5-l6 Spinal Nerve Ligation (Snl) Surgery -Model Of Neuropatmentioning

confidence: 99%

“…von Frey filaments (Touch-Test® Sensory Evaluators, North Coast Medical, Inc., CA, USA) of different forces (0.07g -100g) were used to determine 50% withdrawal thresholds, as previously described (Burke et al, 2013a, Moriarty et al, 2012. Briefly, filaments were applied to the plantar surface of the hind-paw, with sufficient force to cause buckling of the filament, for up to a maximum of 5 seconds or until flinching, licking or withdrawal of the paw occurred.…”

Section: Von Frey Test For Assessing Mechanical Allodyniamentioning

confidence: 99%

“…The acetone drop test was carried 20 min following von Frey testing as previously described (Burke et al, 2013a, Moriarty et al, 2012. A drop of acetone (100%: Sigma-Aldrich, Ireland) was applied to the plantar surface of the hind-paw and latency to first response and withdrawal frequency within 60 seconds was recorded for each trial.…”

Section: Acetone Drop Test For Assessing Cold Allodyniamentioning

confidence: 99%

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Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

Burke¹,

Kerr²,

Moriarty³

et al. 2014

Brain, Behavior, and Immunity

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141

113

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Section: L5-l6 Spinal Nerve Ligation (Snl) Surgery -Model Of Neuropatmentioning

confidence: 99%

Section: Von Frey Test For Assessing Mechanical Allodyniamentioning

confidence: 99%

Section: Acetone Drop Test For Assessing Cold Allodyniamentioning

confidence: 99%

See 1 more Smart Citation

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

Burke¹,

Kerr²,

Moriarty³

et al. 2014

Brain, Behavior, and Immunity

Self Cite

141

113

View full text Add to dashboard Cite

“…Coast Medical, Inc.) of different forces (0.16g -180g) were used to determine the 50% withdrawal threshold as previously described 43 . Briefly, filaments were applied perpendicular to the plantar surface of the hind-paw, with sufficient force to cause slight buckling of the filament, for up to a maximum of 5 seconds or until flinching, licking or withdrawal of the paw occurred.…”

Section: Von Frey Testmentioning

confidence: 99%

“…The acetone-drop test was used to measure responding to an innocuous cold stimulus as previously described 43 . …”

Section: Acetone-drop Testmentioning

confidence: 99%

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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Maternal deprivation is associated with sex dependant alterations in nociceptive behaviour and neuroinflammatory mediators in the rat following peripheral nerve injury. AbstractEarly-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and following peripheral nerve injury (L5-L6 spinal nerve ligation (SNL)). As neuroimmune signalling plays an important role in pain and affective disorders, associated alterations in glial and cytokine expression were assessed in key brain regions associated with emotional and nociceptive responding, the hippocampus and prefrontal cortex (PFC). MD female, but not male, rats exhibited thermal hypoalgesia and mechanical allodynia when compared to control (non-MD) counterparts. SNL resulted in mechanical and cold allodynia in MD and control rats of both sexes. However, MD females exhibited enhanced SNL-induced allodynic responding when compared to non-MD counterparts. IL-6 expression was reduced in the PFC of MD-SNL males when compared with non-SNL counterparts. GFAP and IL-1β expression in the hippocampus of MD-SNL males was increased compared with non-MD controls. MD-SNL females exhibited reduced TNFα in the PFC with a concomitant increase in IL-6 and TNFα expression in the hippocampus, compared with either MD or SNL alone. In conclusion, MD female, but not male, rats exhibit enhanced nociceptive responding following peripheral nerve injury, effects which may relate to the distinct neuroinflammatory profile observed in female versus male rats.Perspective: This study demonstrates that females rats exposed to early-life stress exhibit enhanced neuropathic pain responding, effects associated with alterations in neuroinflammatory mediators. Increased understanding of the interactions between early-life stress, gender and pain may lead to the identification o novel therapeutic targets for the treatment of chronic pain disorders.

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Impact of pain on cognitive processes in animals: behavioral approach and brain structures

Grégoire

2012

Douleur analg

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Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain

Cited by 30 publications

References 57 publications

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Impact of pain on cognitive processes in animals: behavioral approach and brain structures

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