Validation of American College of Rheumatology Classification Criteria for Knee Osteoarthritis Using Arthroscopically Defined Cartilage Damage Scores

Wu, Chung Wah; Morrell, Matthew R.; Heinze, Emil; Concoff, Andrew L.; Wollaston, Sean J.; Arnold, Erin; Singh, Rattandeep; Charles, Christina; Skovrun, Mary Louise; Fitzgerald, John; Moreland, Larry W.; Kalunian, Kenneth C.

doi:10.1016/j.semarthrit.2005.06.002

Cited by 101 publications

(79 citation statements)

References 8 publications

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“…Wu et al [56] believed the American College of Rheumatology (ACR) clinical criteria for OA of the knee [1] could be used to identify early cartilage damage rather than the ACR clinical plus radiographic criteria. They observed a wide distribution of articular cartilage damage in the knees that fulfill the clinical plus radiographic criteria.…”

Section: Discussionmentioning

confidence: 99%

Radiographic Predictability of Cartilage Damage in Medial Ankle Osteoarthritis

Moon¹,

Shim²,

Suh³

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background Radiographic grading has been used to assess and select between treatment options for ankle osteoarthritis. To use radiographic grading systems in clinical practice and scientific studies one must have reliable systems that predict the fate of the cartilage. Questions/purposes We therefore asked whether (1) radiographic grading of ankle osteoarthritis is reliable and (2) grading reflects cartilage damage observed during arthroscopy. We then (3) determined the sensitivity, specificity, and predictive values of the radiographic findings. Patients and MethodsWe examined 74 ankles with medial osteoarthritis and 24 with normal articular cartilage based on arthroscopy. Arthroscopic findings were graded according to the modified Outerbridge grades and all radiographs were graded using the modified KellgrenLawrence, Takakura et al., and van Dijk et al. grading systems. The reliability of each radiographic grading system was evaluated. We correlated the radiographic grades and severity of cartilage damage for each radiographic grading system. Sensitivity, specificity, and predictive values of spurs and joint space narrowing with or without talar tilting then were determined. Results The interobserver weighted kappa ranged from 0.58 to 0.89 and the intraobserver weighted kappa from 0.51 to 0. The positive predictive value of cartilage damage increased from 77% for medial joint space narrowing regardless of the presence of talar tilting to 98% for medial joint space narrowing with talar tilting. Conclusions Our observations suggest the inclusion of talar tilting in grading schemes enhances the assessment of cartilage damage. Level of Evidence Level II, diagnostic study. See the Guidelines for Authors for a complete description of level of evidence.

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Section: Discussionmentioning

confidence: 99%

Radiographic Predictability of Cartilage Damage in Medial Ankle Osteoarthritis

Moon¹,

Shim²,

Suh³

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…27 Statistical heterogeneity across studies was assessed using the Cochrane I 2 metric and chi-square statistics. 28 Since the diagnostic criteria for OA involve clinical and radiological parameters [29][30][31] and evidence has suggested that radiological findings may poorly correlate to clinical presentation 32 , in absence of universally agreed recommendations we initially (primary analyses) pooled HRs of overall mortality as provided by the studies regardless of method of diagnosis.. Joint specific estimates for overall mortality and CVD specific death were computed. Within-study pooled estimates were also calculated as necessary (e.g.…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

Veronese

Cereda

Maggi

et al. 2016

Seminars in Arthritis and Rheumatism

147

102

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Objectives: Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD).Methods: Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA.Risk of call-cause and CVD-mortality were summarized using adjusted hazard ratios (HRs) for joint-specific (hand, hip and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included.Results: From the PRO.V.A. study (N=2,927), there was no significant increase in CVD mortality risk for participants with any-joint OA (N=1,858) compared to non-OA (all-cause, HR=0.95; 95% CI: 0.77-1.15; CVD, HR=1.12; 95% CI: 0.82-1.54).On meta-analysis, seven studies (OA: 10,018/non-OA: 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR=1.10; 95% CI: 0.97-1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR=1.18; 95% CI: 1.08-1.28).There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR=1.21; 95% CI: 1.10-1.34). CVD is potentially preventable through appropriate timely pharmacological and non-pharmacological interventions 10 Therefore, to identify people at higher risk of CVD mortality could be of considerable public health importance.Within the past decade, a number of observational studies have reported that people with OA are at increased risk of premature mortality compared to the general population. [11][12][13] However, this evidence is heterogeneous and limited by the lack of adjustment for appropriate confounders.Given this, the purpose of this study was to: i) analyze data from a prospective cohort study on the risk of CVD mortality in OA compared to a non-osteoarthritis cohort, adjusting for important medical morbidities and other confounders; ii) to systematically review the available literature and perform a meta-analysis to 7 determine whether people with OA present a differential risk of overall and CVD mortality than those without OA. We hypothesized that people with OA had a significant higher risk of overall and CVD death compared to those without OA. 8 MATERIALS AND METHODS Prospective cohort study Overall cohortPreviously unpublished data from the Progetto Veneto Anziani (PRO.V.A. study)were used to investigate the risk of overall and CVD mortality in people with OA over a mean follow-up of 4.4 years. The Pro.V.A. study is an observational cohort study on the Italian population aged over 65 years. The study population initially included 3,099 older Caucasian adults (1,245 men/1,854 women), who were randomly selected between 1995 and 1997 using a multistage stratified met...

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“…The patients met the American College of Rheumatology classification criteria for the diagnosis of osteoarthritis (Wu et al, 2005). Full ethical consent was obtained from all patients and the study was granted ethical approval by the Medical Ethical Committee of Zhongnan Hospital, Wuhan University.…”

Section: In Vitro Experiments Tissue Collectionmentioning

confidence: 99%

Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

et al. 2010

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Abbreviations: ACLT, anterior cruciate ligament transaction; ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; bFGF, basic fibroblast growth factor; Ct, threshold cycle; DMMB, dimethylmethylene blue; ECM, extracellular matrix; GAG, glycosaminoglycan; IGF-1, insulin-like growth factor-1; IL-1Ra, interleukin-1 receptor antagonist protein; MMP, matrix metalloproteinase; OA, osteoarthritis; TIMP, tissue inhibitor of metalloproteinase AbstractThe study investigated the effects of adenovirus-mediated gene transfection of basic fibroblast growth factor (bFGF), bFGF combined with interleukin-1 receptor antagonist protein (IL-Ra) and/or insulin-like growth factor-1 (IGF-1) both in human osteoarthritis (OA) chondrocytes and rabbits OA model. Human OA chondrocytes were delivered by adenovirus-mediated bFGF, IL-Ra and IGF-1 vectors, respectively. Chondrocyte proliferation, glycosaminoglycan (GAG) content, expression of type II collagen, ADAMTS-5, MMP-13, MMP-3 and TIMP-1 were determined. Rabbit OA model was induced by anterior cruciate ligament transaction (ACLT) in knees. Adenoviral vectors encoding human bFGF, IL-Ra and IGF-1 were injected intraarticularly into the knee joints after ACLT. The effects of adenovirus-mediated gene transfection on rabbit OA were evaluated. In vitro, the transfected genes were expressed in cell supernatant of human OA chondrocytes. AdbFGF group significantly promoted chondrocyte proliferation, and increased GAG and type II collagen synthesis than in the OA group. As two or three genes were transfected in different combinations, there was significant enhancement on the GAG content, type II collagen synthesis, and TIMP-1 levels, while ADAMTS-5, MMP-13, and MMP-3 levels were reduced. In vivo, the transfected genes were expressed in synovial fluid of rabbits. Intraarticular delivery of bFGF enhanced the expression of type II collagen in cartilage and decreased cartilage Mankin score compared with the OA control group (P = 0.047; P ＜ 0.01, respectively). Multiple-gene transfection in different combinations showed better results than bFGF transfection alone. This study suggests that bFGF gene transfection is effective in treating experimental OA. Multiple gene transfection has better biologic effects on OA.

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Validation of American College of Rheumatology Classification Criteria for Knee Osteoarthritis Using Arthroscopically Defined Cartilage Damage Scores

Cited by 101 publications

References 8 publications

Radiographic Predictability of Cartilage Damage in Medial Ankle Osteoarthritis

Radiographic Predictability of Cartilage Damage in Medial Ankle Osteoarthritis

Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits

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