Validation of Addenbrooke's cognitive examination for detecting early dementia in a Japanese population

Yoshida, Hidenori; Terada, Seishi; Honda, Hiroki; Ata, Toshie; Takeda, Naoya; Kishimoto, Yuki; Oshima, Etsuko; Ishihara, Takeshi; Kuroda, Shigetoshi

doi:10.1016/j.psychres.2009.06.012

Cited by 70 publications

(39 citation statements)

References 18 publications

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“…The ACE-R has even been validated in a number of languages, although our findings would require replication in different populations to properly assess generalisation 1721 22…”

Section: Discussionmentioning

confidence: 99%

The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders

Rittman

Ghosh

McColgan

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

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ObjectiveDifferentiating idiopathic Parkinson's disease from atypical parkinsonian syndromes is challenging, especially in the early stages. We assessed whether the Revised Addenbrooke's Cognitive Examination (ACE-R) could differentiate between parkinsonian syndromes and reflect longitudinal changes in cognition in these disorders.MethodsThe ACE-R was administered at baseline and after approximately 18 months to 135 patients with parkinsonian disorders: 86 with idiopathic Parkinson's disease (PD), 30 with progressive supranuclear palsy (PSP), 19 with corticobasal degeneration (CBD). We assessed differences between groups for ACE-R, ACE-R subscores and Mini Mental State Examination (MMSE) scores at baseline (analyses of variance, receiver operating characteristics curves), and the interaction between diagnosis and change in ACE-R scores between visits (analyses of variance).ResultsThe ACE-R verbal fluency subscore distinguished between PSP and PD with a high sensitivity (0.92) and specificity (0.87); total ACE-R score and the visuospatial subscore were less specific (0.87 and 0.84 respectively) and sensitive (0.70 and 0.73). Significant group level differences were found between PD and PSP for MMSE and ACE-R (total score and subscores for attention and concentration, fluency, language, and visuospatial function), and between PD and CBD for the ACE-R visuospatial subscore. Performance worsened between visits for ACE-R score in PD (p=0.001) and CBD (p=0.001); visuospatial subscore in PD (p=0.003), PSP (p=0.022) and CBD (p=0.0002); and MMSE in CBD (p=0.004).ConclusionsWe propose the ACE-R, particularly the verbal fluency subscore, as a valuable contributor to the differential diagnosis of parkinsonian syndromes in the correct clinical context. The ACE-R may reflect disease progression in PD and CBD.

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“…The ACE-R has even been validated in a number of languages, although our findings would require replication in different populations to properly assess generalisation 1721 22…”

Section: Discussionmentioning

confidence: 99%

The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders

Rittman

Ghosh

McColgan

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

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“…It is more sensitive and reliable than the MMSE for the early detection of dementia in Alzheimer's disease and frontotemporal dementia [9,10]. The ACE has been used to assess cognitive impairment in other neuropsychiatric entities such as Parkinson's disease [11], corticobasal degeneration, progressive supranuclear palsy, other Parkinsonian syndromes [12,13],depression [14,15], and Vascular Dementia [16,17] among others. In 2006, the ACE was revised and data of this new version have been published by Mioshi et al In this revised version, referred to as ACE-R, design changes were implemented to make the test easier to administrate, to facilitate cross-cultural usage, and to increase sensitivity and specificity [18].…”

Section: Introductionmentioning

confidence: 99%

The Spanish version of the Addenbrooke's Cognitive Examination — Revised (ACE-R) in subcortical ischemic vascular dementia

Raimondi

Gleichgerrcht

Richly

et al. 2012

Journal of the Neurological Sciences

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“…The ACE – lately translated into Malayalam [7], French [8], Spanish [9], German [10], Hebrew [11], Danish [12] and Japanese [13 ]– was then revised (ACE-R) [14] in order to make the test easier to administer and to increase its sensitivity and specificity. In addition, three parallel forms were developed to avoid practice effects [14].…”

Section: Introductionmentioning

confidence: 99%

Validation Study of the Italian Addenbrooke’s Cognitive Examination Revised in a Young-Old and Old-Old Population

Pigliautile

Ricci

Mioshi

et al. 2011

Dement Geriatr Cogn Disord

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Aims: The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke’s Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population. Methods: The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4 ± 6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (<75 years) and an old-old (≧75 years) group, in order to evaluate the sensitivity and specificity of the test in detecting dementia in different age strata of elderly subjects. Results: The reliability of the Italian ACE-R was extremely good (α-coefficient = 0.85). Two different cutoffs were identified for young-old (cutoff 79; sensitivity 90% and specificity 80%) and old-old subjects (cutoff 60; sensitivity 82% and specificity 100%). Conclusions: The Italian ACE-R is a valid screening tool to detect dementia, especially in the old-old population, which represents not only the fastest growing age group but also the group at the highest risk of dementia in Western countries.

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Validation of Addenbrooke's cognitive examination for detecting early dementia in a Japanese population

Cited by 70 publications

References 18 publications

The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders

The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders

The Spanish version of the Addenbrooke's Cognitive Examination — Revised (ACE-R) in subcortical ischemic vascular dementia

Validation Study of the Italian Addenbrooke’s Cognitive Examination Revised in a Young-Old and Old-Old Population

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