Validation of a Serologic Test for the Diagnosis of Helicobacter pylori Infection and the Immune Response to Urease and CagA in Children

Abstract

A serodiagnosis of H. pylori infection using native strains was developed. The difference in the immune response between children with RAP and control subjects suggests that RAP occurs during the acute phase of H. pylori infection. Our results also suggest that urease is a poor immunogen.

A Prospective Study for the Association of Helicobacter pylori Infection to a Multidimensional Measure for Recurrent Abdominal Pain in Children

“…As childhood is the time of high risk for H. pylori acquisition [10–13] and RAP is a common health problem among children, H. pylori has been postulated as an important etiologic factor for RAP. In fact, several studies have shown that the prevalence of H. pylori infection was up to 81% among children with RAP [23,27–29]. Although we found no difference in the overall prevalence of H. pylori between asymptomatic children and children with RAP, we did find a striking difference in the epidemiologic patterns among both groups.…”

Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa

“…Diagnosis of H. pylori infection was done by serology (total H. pylori extract and CagA protein) with an ELISA, as previously described. 17 …”

The Association of Intestinal Parasitosis and H. Pylori Infection in Children and Adults from a Mexican Community with High Prevalence of Parasitosis

“…pylori status was determined by detection of IgG antibodies to specific H. pylori antigens by an ELISA previously validated for use in children and adults in Mexico [18]. pylori status was determined by detection of IgG antibodies to specific H. pylori antigens by an ELISA previously validated for use in children and adults in Mexico [18].…”