Validation of a seizure-related injury model

Tiamkao, Somsak; Kaewkiow, Noppamas; Pranbul, Sineenard; Sawanyawisuth, Kittisak

doi:10.1016/j.jns.2013.10.019

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…The overall estimated prevalence of seizure-related physical injury and type of injury is similar with a study carried out in UK (27%); the study reported that soft-tissue injury accounts for 61%, burns account for 17%, head injuries account for 14%, and orthopaedic injuries account for 5% [ 19 ]. The reported prevalence of seizure-related physical injuries in our study is lower than the studies carried out in Thailand 38.6% [ 20 ], Nigeria 45.6% to 67.8% [ 21 , 22 ], and Iran 47.3% [ 12 ]. However, the findings from our study were higher than the previous studies carried out in Ethiopia (9%) [ 16 ], in a European cohort 17% [ 10 ], and Nova Scotia (17%) [ 23 ].…”

Section: Discussioncontrasting

confidence: 83%

Seizure-Related Injuries among People with Epilepsy at the Outpatient Department of the University of Gondar Hospital, Northwest Ethiopia: Cross-Sectional Institutional-Based Study

Bifftu

Tiruneh

Mekonnen

et al. 2017

Neurology Research International

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Background The characteristics of epilepsy such as the episodic nature of impairment of consciousness and motor control, psychomotor comorbidity, seizure frequency, and side effects of antiepileptic drugs impact negatively on the physical safety of the patients. Physical injuries such as burn, fracture, dental loss, and hemorrhage affect the quality of patients' life to the extent of death. Thus, the main purpose of this study was to assess the prevalence of physical injury and associated factors among people with epilepsy. Methods The study was carried out among 409 people with epilepsy. Cross-sectional study design was utilized to enroll the selected study participants using systematic random sampling technique. Binary and multivariable logistic regression were fitted to identify associated factors using an odds ratio and 95% CI. Results The overall estimated prevalence of seizure-related physical injury was found to be 27.9%. Of the 27.9% seizure-related physical injuries, 12.5% had abrasions, 5.9% had burns, 4.4% had dental injuries, 2.2% had fractures, and 1.5% had head injuries and dislocations, respectively. Employment, 2-3 years duration of illness, seizure frequencies, and frequencies of drug taken were factors associated with physical injury. Conclusion More than a quarter of the study participants experienced physical injury. Designing/strengthening injury prevention strategies is suggested especially for those who had uncontrolled seizure frequency for longer period of time.

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Section: Discussioncontrasting

confidence: 83%

Seizure-Related Injuries among People with Epilepsy at the Outpatient Department of the University of Gondar Hospital, Northwest Ethiopia: Cross-Sectional Institutional-Based Study

Bifftu

Tiruneh

Mekonnen

et al. 2017

Neurology Research International

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“…The prevalence and type of injury were in line with a study carried out in Gondar hospital (27.9%) where abrasion, burn and head injury were the commonest, 7 in the UK (27%) burn and head injuries were the commonest. 23 However, the prevalence in this study was lower than the studies conducted in Thailand (38.6%) 24 and Nigeria (45.6%). 25 These differences may be due to seizure severity, duration of the seizure, and type of seizure.…”

Section: Discussioncontrasting

confidence: 73%

<p>Antiepileptic Drug Treatment Outcomes and Seizure-Related Injuries Among Adult Patients with Epilepsy in a Tertiary Care Hospital in Ethiopia</p>

Nasir

Yifru

Engidawork

et al. 2020

PROM

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Objective: Anti-epileptic drugs (AEDs) are the primary therapeutic modalities for epilepsy management. However, one-third of epileptic patients continue to experience seizure even with appropriate AED use. Patients with epilepsy are at increased risk for seizure-related injury and they have higher incidences of home, street and work accidents. There is a paucity of data on AED use pattern and treatment outcomes among patients with epilepsy in the tertiary hospitals of Ethiopia. Therefore, the aim of this study was to assess AED use pattern, treatment outcome, and prevalence of seizure-related injury among patients with epilepsy in Tikur Anbessa specialized Hospital (TASH), Ethiopia. Patients and Methods: An institution-based cross-sectional study was carried out on 291 patients with epilepsy attending the neurology clinic of TASH. A semi-structured questionnaire and data abstraction format were used to collect data through patient interview and medical chart review. Binary logistic regression was utilized to identify the associated factors of treatment outcome. Results: About 172 (59%) of the patients were taking a single AED, in which phenobarbital, 195 (67%), and phenytoin, 97 (33.3%), were the most frequently prescribed AEDs as monotherapy and combination therapy. Headache, depressed mood and epigastric pain were frequently reported as adverse drug reactions. Seizure-related injury was reported among 78 (26.8%) patients and head injury 15 (5.2%), desntal injury 15 (5.2%), soft tissue injury 14 (4.8%) and burns 10 (3.4%) were the commonest. About two-thirds (191, 65.6%) of the study participants had uncontrolled seizure. Medication adherence and multiple AEDs were significantly associated with treatment outcome. Conclusion: All the study participants were put on old generation AEDs with phenobarbital being the most frequently used. About two-thirds of the patients had uncontrolled seizure and seizure-related injury is still a serious concern among patients with epilepsy.

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“…33 In Thailand, many studies have reported that patients with epilepsy have a 38.6% to 57% chance of having accidental seizures. 5,17 In this study, the mean value of this variable was obtained from a study carried out in Khon Kaen Hospital, which reported that 43.3% of patients with epilepsy had experienced accidental seizures, because this percentage is close to the average range in the Thai literature. Meanwhile, the incidence of accidents owing to seizures in foreign countries was found to be about 17% to 55%.…”

Section: Discussionmentioning

confidence: 95%

“…4,16 6. Owing to lack of data reporting the disability rate in epilepsy patients in Thailand, the rate of disability was referred from the rate of skull fracture-related seizures (4%), 17 and the death rate was reported at 0.5% 18 as shown in Table 2.…”

Section: Model Assumptionsmentioning

confidence: 99%

Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand

Tiamkao

Suthipinijtham²

2020

Value in Health Regional Issues

Self Cite

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Objectives: There was higher frequency of breakthrough seizures during immediate-release phenytoin capsule usage than during extended-release phenytoin capsule usage by epilepsy patients. This study aimed to estimate the total budget of using extended-release phenytoin compared with immediate-release phenytoin capsules.Methods: A decision tree model was developed for 3 scenarios in Thailand where (1) extended-release phenytoin, (2) immediate-release phenytoin, and (3) both forms, as per the market share, were prescribed. All parameters were derived from the literature reviews and hospital database and analyzed from payer and societal perspectives.

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Validation of a seizure-related injury model

Cited by 5 publications

References 9 publications

Seizure-Related Injuries among People with Epilepsy at the Outpatient Department of the University of Gondar Hospital, Northwest Ethiopia: Cross-Sectional Institutional-Based Study

Seizure-Related Injuries among People with Epilepsy at the Outpatient Department of the University of Gondar Hospital, Northwest Ethiopia: Cross-Sectional Institutional-Based Study

<p>Antiepileptic Drug Treatment Outcomes and Seizure-Related Injuries Among Adult Patients with Epilepsy in a Tertiary Care Hospital in Ethiopia</p>

Budget Impact Analysis of Extended-Release Phenytoin Capsules Compared With Immediate-Release Phenytoin Capsules for Patients With Epilepsy in Thailand

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