Validation of a Screening Questionnaire for the Detection of Epileptic Seizures in Epidemiological Studies

Placencia, M.; Sander, Josemir W.; Shorvon, Simon; Ellison, R.H.; S, Cascante

doi:10.1093/brain/115.3.783

Cited by 141 publications

(151 citation statements)

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“…Screening instrument -We adopted the screening questions of the instrument used in the Ecuadorian study of epilepsy prevalence carried out by Placencia et al [7][8][9] . The questionnaire had been translated into Portuguese and pretested in 30 patients on clinical grounds (15 with epilepsy, and the other 15, without).…”

Section: Methodsmentioning

confidence: 99%

A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil

Gomes

Zeitoune

Kropf

et al. 2002

Arq. Neuro-Psiquiatr.

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-Objective: To carry out a prevalence study about epileptic seizures and epilepsy in an urban lowincome population. Method: Prevalence study in a two-phase model: screening and diagnosis confirmation. It was applied a structured questionnaire in 982 people all effectively resident on March 1rst 2000 based on a population census previously carried out by the Nurse Faculty. One neurologist interviewed all the suspected cases. Results: It was detected 176 suspected cases of epileptic seizures: 156 with non-epileptic events, and 20 with epileptic seizures. The lifetime point prevalence was of 16.3 cases per 1000 inhabitants, and of active epilepsy, 5.1 / 1000. If we consider false negative diagnosis from the screening procedures, the lifetime pointprevalence rates until 20.8/1000. Conclusion: The prevalence data of epilepsy shows less impressive than in other Latin-American studies and even some Brazilian, but similar to other Brazilian studies. This suggests geographical diversity and/or methodological differences among studies. Anyway, probably the epilepsy prevalence in Rio de Janeiro is not so high as that found in the Latin countries rural areas.KEY WORDS: epilepsy, prevalence, community study.Estudo porta-a-porta sobre crises epilépticas em comunidade urbana do Rio de Janeiro, Brasil RESUMO -Objetivo: Estudar a prevalência de crises epilépticas e epilepsia em uma população urbana de baixa renda do Rio de Janeiro. Método: Estudo de prevalência, em um modelo de duas etapas: de triagem e de confirmação diagnóstica. Foi aplicado questionário estruturado de triagem em 982 pessoas. Todos os efetivamente residentes na comunidade em primeiro de março de 2000 (dia prevalente) eram os sujeitos em potencial. A população de estudo foi aquela que constava no censo efetuado pela Escola de Enfermagen Anna Nery. Um neurologista entrevistou os sujeitos suspeitos de apresentarem crises epilépticas. Resultados: Foram detectados 176 casos suspeitos de crises epilépticas: 156 casos com eventos não epilépticos e 20 com crises epilépticas. A prevalência acumulada na comunidade foi 16,3 casos por 1000 habitantes e a de epilepsia ativa foi 5,1 / 1000. Caso se considere o diagnóstico falso negativo da fase de triagem, a prevalência acumulada iria a 20,8/1000. Conclusão: Os dados de prevalência mostram-se menores do que de outros países latinoamericanos e mesmo de alguns brasileiros, mas similares a outros nacionais, o que sugere diversidade geográfica e/ou diferenças metodológicas entre os estudos. A prevalência de epilepsia no Rio de Janeiro provavelmente não é tão alta quanto a de outros países latinos, principalmente nas suas regiões rurais. PALAVRAS-CHAVE: epilepsia, prevalência, estudo de campo.

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Section: Methodsmentioning

confidence: 99%

A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil

Gomes

Zeitoune

Kropf

et al. 2002

Arq. Neuro-Psiquiatr.

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“…23 This instrument was translated into Kiswahili and back-translated. The details of any children who responded positively to one or more questions in the screening questionnaire, together with those considered by trained enumerators as likely to have epilepsy, were identified (see Fig.…”

Section: Case Ascertainment and Criteria For Inclusion And Exclusionmentioning

confidence: 99%

Behavioural comorbidity in Tanzanian children with epilepsy: a community-based case-control study

Burton

Rogathe

Hunter

et al. 2011

Developmental Medicine &Amp; Child Neurology

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AIM The aim of this study was to define the prevalence of and risk factors for behavioural disorders in children with epilepsy from a rural district of Tanzania by conducting a communitybased case-control study.METHOD One hundred and twelve children aged 6 to 14 years (55 males, 57 females; median age 12y) with active epilepsy (at least two unprovoked seizures in the last 5y) were identified in a cross-sectional survey and included in this study. Children who were younger than 6 years were excluded in order to eliminate febrile seizures. Behaviour was assessed using the Rutter scale; children who scored 13 or more were considered to have disordered behaviour. A comparison group was made up of age-and sex-matched children without epilepsy (n=113; 57 males, 56 females; median age 12y).RESULTS Behavioural disorders were diagnosed in 68 of 103 (66%) children with epilepsy and in 19 of 99 (19%) controls. Disordered behaviour was significantly more common in children with epilepsy than in the comparison group (univariate odds ratio 8.2; 95% confidence interval [CI] 4.3-15.6; p<0.001) and frequent seizures and poor scholastic attainment were associated in children with epilepsy. Behavioural disorders were not associated with antiepileptic drug usage. Attention problems were present in 48 of 91 (53%) children with epilepsy and 16 of 97 (17%) controls (univariate odds ratio 5.7; 95% CI 2.9-11.1; p<0.001). In children with epilepsy, attention problems were significantly more common in males and were associated with frequent seizures.INTERPRETATION Children with epilepsy in a rural area of sub-Saharan Africa have a high prevalence of behavioural disorders and attention problems, both of which are associated with frequent seizures. Providing behaviour assessment and appropriate intervention programmes for children with epilepsy may reduce the burden of behaviour disorders in this setting.Epilepsy is the most common neurological disorder worldwide; it is estimated that 80% of affected children live in resource-poor countries. 1 The prevalence of behavioural disorders in children in urban settings in high-income countries is greater in those with epilepsy than in those without epilepsy 2,3 and is greater than in those with other chronic conditions such as diabetes and asthma. 2,4,5 In high-income countries, the prevalence of behavioural disorders in children with epilepsy ranges from 20 to 60%. [6][7][8][9][10] Behavioural disorders are associated with early onset of seizures, 11 certain seizure types, 11 increased seizure frequency, 7,11 polytherapy, 12 cognitive impairment, 3 family factors, parenting practices, and infant temperament. [13][14][15] There are limited data on the prevalence and nature of behavioural problems in children with epilepsy in low-income countries. Two studies from India found similar rates of behavioural (54%) and psychiatric disorders (23%) to those reported from high-income countries. 16,17 There are only a few studies on behavioural disorders in children with epilepsy from Africa. A study...

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“…This tool has been shown to be 79% sensitive and 93% specific in the detection of epilepsy. 8 Children with preexisting unprovoked seizures were excluded from the study. Those who screened positive on the Ten Questions and were found to have preexisting neurodisabilities were enrolled but evaluated only for the development of epilepsy and behavioral disorders.…”

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confidence: 99%

Neurologic outcomes in retinopathy-negative cerebral malaria survivors

et al. 2012

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Objectives: Patients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes. Between 2005 and 2007, survivors of CM and concurrently hospitalized controls in Blantyre, Malawi, were followed to assess the development of neurologic abnormalities. At discharge and every 3 months thereafter, incident cases of epilepsy and developmental disabilities were ascertained using screening questionnaires and confirmatory neurologic examinations. Incident cases of epilepsy and developmental disabilities were compared in retinopathy-negative CM survivors to controls and retinopathy-positive CM survivors. Methods:Results: Thirty-five retinopathy-negative CM survivors were enrolled. Their neurologic outcomes were compared to 132 retinopathy-positive CM survivors and 272 controls. Compared to survivors of retinopathy-positive CM, children without malaria retinopathy have an equal odds of adverse neurologic outcome (odds ratio [OR] ϭ 1.0, 95% confidence interval [CI] 0.4-2.2). Eleven of 35 survivors of retinopathy-negative CM had at least 1 adverse neurologic outcome compared to 2 of 272 controls (OR 61.9, 95% CI 13.0-295.5). In retinopathy-negative CM survivors, a Blantyre Coma Scale score Յ1 on admission was associated with an adverse outcome. Conclusions:Compared with controls, children surviving either retinopathy-negative or -positive CM are at similar high risk for adverse neurologic outcomes. Studies to evaluate preventive and therapeutic strategies in children with both retinopathy-negative and -positive CM are needed to improve mortality, morbidity, or both. Neurology Cerebral malaria (CM) is defined as an otherwise unexplained coma in a patient with circulating Plasmodium falciparum parasitemia.1 Children with CM are not a homogeneous group. A clinical-autopsy study revealed that approximately 23% of children meeting case criteria for CM lacked evidence of sequestration of parasitized red blood cells in cerebral vasculature.2 This pathologic finding is thought to indicate that P falciparum was most likely responsible for the patient's illness and coma. Premorbid differentiation of children with case-defined CM but without cerebral sequestration was impossible until the description of malaria retinopathy and correlation of retinopathy status with autopsy findings. The presence of malaria retinopathy is 95% sensitive and 90% specific for the histologic presence of sequestered parasitized erythrocytes and suggests that the clinical syndrome in an individual patient is likely caused by P falciparum. Retinopathy-negative CM may represent an asymptomatic incidental parasitemia with a second exposure (possibly viral) producing fever and coma.4 A clinical-autopsy study supported

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Validation of a Screening Questionnaire for the Detection of Epileptic Seizures in Epidemiological Studies

Cited by 141 publications

References 1 publication

A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil

A house-to-house survey of epileptic seizures in an urban community of Rio de Janeiro, Brazil

Behavioural comorbidity in Tanzanian children with epilepsy: a community-based case-control study

Neurologic outcomes in retinopathy-negative cerebral malaria survivors

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