Validation of a rapid micellar electrokinetic capillary chromatographic method for the simultaneous determination of isoniazid and pyridoxine hydrochloride in pharmaceutical formulation

Micellar electrokinetic chromatography: Methodological and instrumental advances focused on practical aspects

“…Thus, optimization of separation parameters for the baseline resolution and short migration times has been the subject of studies reported by several authors using different approaches in the period covered by this review 125–129. Statistical experimental 125 and factorial 126, 127 designs, multilinear regression 128 and genetic algorithms 129 are the chemometric tools used to search for the optimum conditions in MEKC separation. In general, resolution, peak symmetry and analysis time are established as responses in the approaches tested, which provide a good optimization of the MEKC buffer system.…”

Application of the cobaltabisdicarbollide anion to the development of ion selective PVC membrane electrodes for tuberculosis drug analysis

“…Some reported methods for pharmaceutical analysis require a long sample pre-treatment and expensive apparatus. [18][19][20][21] In contrast, ISEs represent a simple and rapid technique but they need to be selective. Therefore, the improvement of the selectivity opens the way to further investigations.…”

Capillary electrophoresis analysis of isoniazid using luminol‐periodate potassium chemiluminescence system

“…The relative standard deviations (RSDs) of the signal intensity and the migration time were 3.1 and 1.4% for a standard sample at 1.0 × 10 −5 g mL −1 ( n = 5), respectively. Compared with other assay methods reported previously (6,10,31,32), the proposed CE‐CL system showedlower LOD, higher precision and shorter assay time (as shown in Table 1).…”