Validation of a radiographic scoring system for haemochromatosis arthropathy

Dallos, Tomáš; Sahinbegovic, Enijad; Aigner, Elmar; Axmann, Roland; Schöniger–Hekele, Maximilian; Karonitsch, Thomas; Stamm, Tanja; Farkas, Martin; Karger, Thomas; Cavallaro, Alexander; Stölzel, Ulrich; Keyßer, Gernot; Datz, Christian; Schett, Georg; Manger, Bernhard; Zwerina, Jochen

doi:10.1136/ard.2009.122119

Cited by 30 publications

(28 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The radiologic features of the arthropathy of HH are similar to those in idiopathic OA (26,27). Subchondral sclerosis and joint space narrowing are typical.…”

Section: Is the Arthropathy Inflammatory Or Noninflammatory?supporting

confidence: 51%

Characteristics of the arthropathy described in hereditary hemochromatosis

Carroll¹,

Breidahl²,

Olynyk³

2011

Arthritis Care & Research

View full text Add to dashboard Cite

“…The radiologic features of the arthropathy of HH are similar to those in idiopathic OA (26,27). Subchondral sclerosis and joint space narrowing are typical.…”

Section: Is the Arthropathy Inflammatory Or Noninflammatory?supporting

confidence: 51%

Characteristics of the arthropathy described in hereditary hemochromatosis

Carroll¹,

Breidahl²,

Olynyk³

2011

Arthritis Care & Research

View full text Add to dashboard Cite

“…The relationship between VCAM-1 and HH arthropathy was further investigated using the radiographic haemochromatosis arthropathy score 12. There was a moderate but highly significant correlation between VCAM-1 levels and the MCP 2/3 x-ray score (r=0.36, p<0.0001; figure 2).…”

Section: Resultsmentioning

confidence: 99%

VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis

et al. 2013

Self Cite

View full text Add to dashboard Cite

ObjectivesThe aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy.MethodsSera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures.ResultsVCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age.ConclusionsVCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.

show abstract

“…Standard radiographs of hand, knee, and ankle joints were obtained for the assessment of characteristic radiographic changes in 170 patients (85.4%), and a full set of radiographs (required for the assessment of chondrocalcinosis in all joints) was available for 168 patients (84.4%). A validated dichotomous radiographic scoring system assessing the presence of 4 radiographic features (joint space narrowing, erosions, osteophytes, and chondrocalcinosis) (17) was used for the evaluation of all radiographs. According to this scoring system, 1 point is given for the presence of each of the 4 features; the presence of osteophytes and erosive changes is scored separately at the proximal and distal portions of the assessed joint, thus yielding a total of 6 points if all features are present.…”

Section: Methodsmentioning

confidence: 99%

Musculoskeletal disease burden of hereditary hemochromatosis

Sahinbegovic

Dallos

Aigner

et al. 2010

Arthritis & Rheumatism

Self Cite

View full text Add to dashboard Cite

Objective. To determine the prevalence, clinical picture, and disease burden of arthritis in patients with hereditary hemochromatosis.Methods. In this cross-sectional observational study of 199 patients with hemochromatosis and iron overload, demographic and disease-specific variables, genotype, and organ involvement were recorded. The prevalence, intensity, and localization of joint pain were assessed, and a complete rheumatologic investigation was performed. Radiographs of the hands, knees, and ankles were scored for joint space narrowing, erosions, osteophytes, and chondrocalcinosis. In addition, the number and type of joint replacement surgeries were recorded.Results. Joint pain was reported by 72.4% of the patients. Their mean ؎ SD age at the time of the initial joint symptoms was 45.8 ؎ 13.2 years. If joint pain was present, it preceded the diagnosis of hemochromatosis by a mean ؎ SD of 9.0 ؎ 10.7 years. Bony enlargement was observed in 65.8% of the patients, whereas synovitis was less common (13.6%). Joint space narrowing and osteophytes as well as chondrocalcinosis of the wrist and knee joints were frequent radiographic features of hemochromatosis. Joint replacement surgery was common, with 32 patients (16.1%) undergoing total joint replacement surgery due to severe OA. The mean ؎ SD age of these patients was 58.3 ؎ 10.4 years at time of joint replacement surgery. Female sex, metacarpophalangeal joint involvement, and the presence of chondrocalcinosis were associated with a higher risk of early joint failure (i.e., the need for joint replacement surgery).Conclusion. Arthritis is a frequent, early, and severe symptom of hemochromatosis. Disease is not confined to involvement of the metacarpophalangeal joints and often leads to severe damage requiring the replacement of joints.

show abstract

Validation of a radiographic scoring system for haemochromatosis arthropathy

Abstract: A feasible and reliable radiological assessment tool for the evaluation of haemochromatosis arthropathy has been validated and an atlas of characteristic radiographic features provided.

Cited by 30 publications

References 22 publications

Characteristics of the arthropathy described in hereditary hemochromatosis

Characteristics of the arthropathy described in hereditary hemochromatosis

VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis

Musculoskeletal disease burden of hereditary hemochromatosis

Contact Info

Product

Resources

About