Validation of a novel real time 13C urea breath test for rapid evaluation of Helicobacter pylori in children and adolescents

Levine, Arie; Shevah, Orit; Miloh, Tamir; Wine, Eytan; Niv, Yaron; Bujanover, Yoram; Avni, Yona; Shirin, Haim

doi:10.1016/j.jpeds.2004.03.025

Cited by 12 publications

(14 citation statements)

References 13 publications

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“…The prevalence of H. pylori in Israeli children is higher than that in industrialized countries and has been reported to range between 46 and 58% [21][22][23][24]. In this study we observed several interesting results.…”

Section: Discussionsupporting

confidence: 53%

Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper Endoscopy

et al. 2008

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Section: Discussionsupporting

confidence: 53%

Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper Endoscopy

et al. 2008

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“…Nine studies assessed the UBT in the pre-treatment phase as well as in the posttreatment phase to evaluate the eradication rate of the infection at least 4 to 8 weeks after a variety of treatment regiments [9,21,49,54,68,71,119,122,127]. Depending on the study, the overall average of 13 C-urea dose varied from 50 to 100 mg; in some studies, the dose given depended on the weight of the child [14, 21, 59,86] while in others, the dose depended on the age [20, 51, 55, 79,127].…”

Section: C-urea Breath Testmentioning

confidence: 99%

“…There were nine studies that mentioned the use of UBT 4-8 weeks after treatment for determination of H. pylori eradication [9,21,49,54,68,71,119,122,124] (Table 3). However, this was specifically studied in only four publications [54, 68,122,127].…”

Section: C-urea Breath Testmentioning

confidence: 99%

Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009

et al. 2009

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The array of tests that can be used for diagnosis of Helicobacter pylori infection is large, and it can be confusing to define which test to use particularly in children where results may not be comparable to those obtained in adult patients. Using PubMed, we reviewed the English literature from January 1999 to May 2009 to identify articles that determined sensitivity and specificity of H. pylori invasive and non-invasive diagnostic tests in children. We excluded articles that presented a review of the literature, abstracts, case reports, or series where children's results could not be separated from adult populations. Of the tissue based methods, rapid urease tests have better sensitivity than histology to detect presence of H. pylori; however, histology can detect the pathology associated with disease including gastritis, intestinal metaplasia, and other conditions that could be the cause of the child's symptoms. Culture of gastric tissues or stool has 100% specificity but sensitivity is low. Of the serologic tests, immunoblot has the best sensitivity. The urea breath tests have >75% sensitivity for detection of H. pylori before and after treatment. Immunoassays in stool using monoclonal antibodies have >95% sensitivity for detection of H. pylori before and after treatment. PCR testing can be performed in tissue and stool samples and can detect genes associated to antibiotic resistance. In summary, the current commercial non-invasive tests have adequate sensitivity and specificity for detecting the presence of H. pylori; however, endoscopy with histopathology is the only method that can detect H. pylori and lesions associated with the infection.

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“…The BreathID ® device (Exalenz, Israel) has been validated and cleared by the FDA and has also been previously used on children and adults [2,3]. This office-based system offers several advantages over the conventional mass spectrometry-based UBT, including an immediate test result, a standardized test drink (citric acid) and, most importantly for children, a sampling method that does not require active cooperation.…”

Section: Introductionmentioning

confidence: 99%

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

et al. 2012

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BackgroundCarbon labeled urea breath tests usually entail a two point sampling with a 20 to 30-minute gap. Our aim was to evaluate the duration of time needed for diagnosing Helicobacter pylori by the BreathID® System.MethodsThis is a retrospective multicenter chart review study. Test location, date, delta over baseline, and duration of the entire test were recorded. Consecutively 13C urea breath tests results were extracted from the files over a nine year period.ResultsOf the 12,791 tests results, 35.1% were positively diagnosed and only 0.1% were inconclusive. A statistically significant difference in prevalence among the countries was found: Germany showing the lowest, 13.3%, and Israel the highest, 44.1%. Significant differences were found in time to diagnosis: a positive diagnosis had the shortest and an inconclusive result had the longest. Overall test duration averaged 15.1 minutes in Germany versus approximately 13 minutes in other countries. Diagnosis was achieved after approximately 9 minutes in Israel, Italy and Switzerland, but after 10 on average in the others. The mean delta over baseline value for a negative diagnosis was 1.03 ± 0.86, (range, 0.9 - 5), versus 20.2 ± 18.9, (range, 5.1 - 159.4) for a positive one.ConclusionsThe BreathID® System used in diagnosing Helicobacter pylori can safely shorten test duration on average of 10-13 minutes without any loss of sensitivity or specificity and with no test lasting more than 21 minutes.

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Validation of a novel real time 13C urea breath test for rapid evaluation of Helicobacter pylori in children and adolescents

Cited by 12 publications

References 13 publications

Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper Endoscopy

Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper Endoscopy

Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

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