Validation of a Nomogram Predicting the Probability of Lymph Node Invasion among Patients Undergoing Radical Prostatectomy and an Extended Pelvic Lymphadenectomy

Briganti, Alberto; Chun, Felix K.-H.; Salonia, Andrea; Zanni, Giuseppe; Scattoni, Vincenzo; Valiquette, Luc; Rigatti, Patrìzio; Montorsi, Francesco; Karakiewicz, Pierre I.

doi:10.1016/j.eururo.2006.01.043

Cited by 220 publications

(123 citation statements)

References 30 publications

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“…Locate the sum on the ''Total Points'' line to assess the individual probability of nodal metastases at nephrectomy on the ''Probability of nodal metastases'' line. prostate 12 or bladder 13 cancers, where NM drastically worsen the prognosis. The dismal survival of patients with NM may be improved with the advent of kinase inhibitors, such as sorafenib and sunitinib.…”

Section: Discussionmentioning

confidence: 99%

Patients with renal cell carcinoma nodal metastases can be accurately identified: External validation of a new nomogram

Hutterer

Patard

Perrotte

et al. 2007

Intl Journal of Cancer

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Outcome of patients with renal cell carcinoma nodal metastases (NM) is substantially worse than that of patients with localized disease. This justifies more thorough staging and possibly more aggressive treatment in those at risk of or with established NM. We developed and externally validated a nomogram capable of highly accurately predicting renal cell carcinoma NM in patients without radiographic evidence of distant metastases. Age, symptom classification, tumour size and the pathological nodal stage were available for 4,658 individuals. The data of 2,522 (54.1%) individuals from 7 centers were used to develop a multivariable logistic regression model-based nomogram predicting the individual probability of NM. The remaining data from 2,136 (45.9%) patients from 5 institutions were used for external validation. In the development cohort, 107/2,522 (4.2%) had lymph node metastases vs. 100/2,136 (4.7%) in the external validation cohort. Symptom classification and tumour size were independent predictors of NM in the development cohort. Age failed to reach independent predictor status, but added to discriminant properties of the model. A nomogram based on age, symptom classification and tumour size was 78.4% accurate in predicting the individual probability of NM in the external validation cohort. Our nomogram can contribute to the identification of patients at low risk of NM. This tool can help to risk adjust the need and the extent of nodal staging in patients without known distant metastases. More thorough staging can hopefully better select those in whom adjuvant treatment is necessary. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Patients with renal cell carcinoma nodal metastases can be accurately identified: External validation of a new nomogram

Hutterer

Patard

Perrotte

et al. 2007

Intl Journal of Cancer

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“…Multiple prediction tables or nomograms have been published with significant variation in their predictive accuracy. [15][16][17][18] Two commonly used tools, an update of the Partin tables 15 and the preoperative nomogram by Cagiannos and colleagues, 16 reported accuracies of only 76% in validation studies. Furthermore, most of these tools were developed in populations with only a limited PLND (with LNI <1%) 19,20 and therefore seriously underestimated the true presence of LNI.…”

Section: Staging Issuesmentioning

confidence: 99%

Why all prostate cancer surgery should include an adequate lymph node dissection

Siemens

2013

CUAJ

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“…6,7 Most nomograms are based on simple and routinely available clinical and/or pathological predictors. [8][9][10] The advantages of these tools are their applicability to all patients regardless of their perioperative risk. Moreover, they do not contribute to additional operating time, additional cost and, most importantly, they do not contribute to morbidity.…”

Section: Point/counterpointmentioning

confidence: 99%

Should all men having a radical prostatectomy have a pelvic lymph node dissection? No

Abdollah

Sun

Thuret

et al. 2013

CUAJ

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Validation of a Nomogram Predicting the Probability of Lymph Node Invasion among Patients Undergoing Radical Prostatectomy and an Extended Pelvic Lymphadenectomy

Cited by 220 publications

References 30 publications

Patients with renal cell carcinoma nodal metastases can be accurately identified: External validation of a new nomogram

Patients with renal cell carcinoma nodal metastases can be accurately identified: External validation of a new nomogram

Why all prostate cancer surgery should include an adequate lymph node dissection

Should all men having a radical prostatectomy have a pelvic lymph node dissection? No

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