The objective of the study was to evaluate the precision, concordance, practicability and the early clinical outcome in the use of a computerised navigation system in a comparative study with a group of 100 patients. Two groups of 50 patients each underwent alternately the implantation of a bicondylar knee prosthesis either by means of the freehand navigation system or by means of technical instrumentation. It was found that the computerised navigation-system provided a far higher precision than the technical instrumented implantation. Thus, 94% of the prosthesis implanted with the navigation-system have shown an alignment within a range of plus/minus 3°of the Mikulicz line. Only 46% of the patients operated by means of the technical instrumentation reached this aspired result. Furthermore, the navigation system showed far smaller ranges in the deviation of the aspired alignment. The radiological and virtually alignment values differ at both time points pre and post operative but to a larger extend before surgery. The varus or valgus deviations of the axis appear to be more distinct radiologically under the weight of the patient's body than in the virtual model. The clinical outcome examined by the use of the HSS-Score after a mean follow up of 7 months is very good in both groups, not showing significant differences. On average, the duration of surgery was 13 min longer in the navigated group. We conclude that the benefit of the computerised navigation system is represented in the high improvement of precision. Achieving identical early clinical results like by usage of the technical instrumentation we expect a reduction of aseptic loosening in the navigated group.