Validation of a new pediatric air-displacement plethysmograph for assessing body composition in infants

Ma, Guansheng; Yao, Manjiang; Liu, Yan; Lin, Aiwei; Zou, Hui; Urlando, Alessandro; Wong, William W.; Nommsen‐Rivers, Laurie; Dewey, Kathryn G.

doi:10.1093/ajcn/79.4.653

Cited by 229 publications

(245 citation statements)

References 34 publications

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“…The infant size instrument (PeaPod, weight limit of 8 kg) has been validated in several studies. 5,4,[38][39][40] The procedure is easy, quick and results in excellent body fat measurement precision. …”

Section: Discussionmentioning

confidence: 99%

QMR: validation of an infant and children body composition instrument using piglets against chemical analysis

2010

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Objective: This study was undertaken to validate the first quantitative nuclear magnetic resonance (QMR) instrument designed and built to assess body composition in children from birth to adulthood (up to 50 kg). Design: A total of 50 pigs weighing between 3.0 and 49.1 kg were studied. Each piglet's body composition was assessed by quantitative nuclear magnetic resonance (QMR, EchoMRI-AH small), whole-body chemical carcass analysis for lipid and water content, and dual-energy X-ray absorptiometry (DXA, Hologic QDR 4500, using infant or adult whole-body scan acquisition programs where appropriate). Twenty-five piglets (3.1-47.2 kg) were randomly selected to calibrate the QMR instrument. The remaining 25 piglets (3.0-49.1 kg) were used to validate the instrument. Results: The precision of QMR to estimate fat mass (FM), fat-free mass (FFM) and total body water (TBW) for five consecutive scans was excellent (1.3, 0.9 and 0.9%, respectively). QMR measures of FM were highly and significantly correlated with chemical carcass analyses and DXA measures (r 2 ¼ 0.99 and r 2 ¼ 0.98, respectively). QMR and DXA FFM results were highly correlated (R 2 ¼ 0.99, Po0.01). TBW measures were strongly correlated between QMR and carcass analyses (R 2 ¼ 0.99, Po0.01). QMR overestimated FM by 2% and DXA measures (using the infant and adult scan programs) overestimated FM by 15% on average. Conclusion: QMR provides precise and accurate measures of FM, FFM and TBW in piglets weighing up to 50 kg. As the piglet is considered to be an excellent model of human development, these data suggest that QMR should provide the opportunity to acquire valuable body composition data in longitudinal studies in children, which is not possible or practical with other commercially available instrumentation.

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Section: Discussionmentioning

confidence: 99%

QMR: validation of an infant and children body composition instrument using piglets against chemical analysis

2010

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“…A detailed description of the PEA POD's physical design, operating principles, validation, and measurement procedures is provided elsewhere (21,22). Briefly, the PEA POD assesses fat mass and "FFM" by direct measurements of body mass and volume and the application of a classic densitometric model in which percentage of body fat is calculated using body density and predetermined fat and FFM density values.…”

Section: Growth and Body Composition Assessmentmentioning

confidence: 99%

Postnatal catch-up fat after late preterm birth

et al. 2012

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Background: Late preterm birth accounts for 70% of preterm births. The aim of the study was to investigate the postnatal weight gain and weight gain composition changes in a cohort of late preterm infants. Methods: a total of 49 late preterm infants (mean birth weight 2,496 ± 330 g and gestational age 35.2 ± 0.7 wks) underwent growth and body composition assessment by an air displacement plethysmography system on the fifth day of life, at term, and at 1 and 3 mo of corrected age. The reference group was composed of 40 healthy, full-term, breast-fed infants. results: The late preterm infants showed a Δ fat mass gain between birth and term-corrected age equal to 182%. as compared with full-term infants, at term and 1 mo of corrected age mean weight (3,396 ± 390 vs. 3,074 ± 409 g and 4,521 ± 398 vs. 4,235 ± 673 g, respectively) and percentage of fat mass (16.1 ± 4.6 vs. 8.9 ± 2.9 and 22.6 ± 4.2 vs. 17.4 ± 4.0, respectively) were significantly higher in late preterm infants, whereas no difference among groups was found at 3 mo. conclusion: Rapid postnatal catch-up fat was found in these infants. Further studies are needed to investigate whether this short-term increase in fat mass may modulate the risk of chronic diseases or represent an adaptive mechanism to extrauterine life.

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“…Recently, a new technology using air displacement plethysmography (ADP) has become available to noninvasively, accurately, and quickly measure BF% in infants from birth to 6 mo of age. ADP has been validated against the four-compartment model and biological and physical phantoms (13) and is considered the criterion method for determining BF% in neonates (14)(15)(16)(17)(18). Several studies have investigated the BF% as the indicator of neonatal nutritional status using ADP (13,(19)(20)(21).…”

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confidence: 99%

Is body fat percentage a better measure of undernutrition in newborns than birth weight percentiles?

et al. 2013

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Background: Undernutrition in neonates increases the risk of serious morbidities. The objective of this study was to describe neonatal morbidity associated with low body fat percentage (BF%) and measure the number of undernourished neonates defined by BF% and compare this with birth weight percentiles (<10th). Methods: Eligibility included term (≥37 wk) neonates. BF% measurements were undertaken by air displacement plethysmography. Data on neonatal outcomes were extracted from medical records and used to develop a measure of neonatal morbidity. We assessed the association between neonatal morbidity and population-based birth weight percentiles compared with the BF% measurements. results: Five hundred and eighty-one neonates were included. Low BF% was defined by 1 SD below the mean and identified in 73 per 1,000 live births. Neonatal morbidity was found in 3.4% of neonates. Birth weight percentile was associated with neonatal morbidity (odds ratio (OR): 1.03 (95% confidence interval (CI): 1.01, 1.05); P = <0.001). BF% was associated with a higher risk of neonatal morbidity (OR: 1.30 (95% CI: 1.15, 1.47); P = <0.001). conclusion: In this population, measuring BF% is more closely associated with identification of neonates at risk of neonatal morbidity as compared with birth weight percentiles. BF% measurements could assist with identifying neonates who are appropriately grown yet undernourished and exclude small neonates not at risk.

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Validation of a new pediatric air-displacement plethysmograph for assessing body composition in infants

Abstract: ADP is a reliable and accurate instrument for determining %BF in infants, and it has the potential for use in both research and clinical settings.

Cited by 229 publications

References 34 publications

QMR: validation of an infant and children body composition instrument using piglets against chemical analysis

QMR: validation of an infant and children body composition instrument using piglets against chemical analysis

Postnatal catch-up fat after late preterm birth

Is body fat percentage a better measure of undernutrition in newborns than birth weight percentiles?

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