Validation of a machine learning approach using FIB-4 and APRI scores assessed by the metavir scoring system: A cohort study

Hashem, Ahmed M.; Awad, Abeer; Shousha, Hend Ibrahim; Alakel, Wafaa; Salama, Asmaa; Awad, Tahany; Mabrouk, Mahasen

doi:10.1016/j.ajg.2021.04.003

Cited by 5 publications

(5 citation statements)

References 23 publications

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“… 22 However, there exist others that have found it to have limited accuracy in particular situations, such as in extensive fibrosis. 12 , 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

Aspartate Aminotransferase–to–Platelet Ratio Index Suggestive of Liver Dysfunction Predicts Early Complications After Open Reduction Internal Fixation of Distal Radius Fractures

Liu,

Burgan,

Ling

et al. 2024

Journal of Hand Surgery Global Online

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“… 22 However, there exist others that have found it to have limited accuracy in particular situations, such as in extensive fibrosis. 12 , 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

Aspartate Aminotransferase–to–Platelet Ratio Index Suggestive of Liver Dysfunction Predicts Early Complications After Open Reduction Internal Fixation of Distal Radius Fractures

Liu,

Burgan,

Ling

et al. 2024

Journal of Hand Surgery Global Online

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“…Third, we estimated liver fibrosis with FIB-4, which has not been validated against the gold standard of liver biopsy for alcohol-related liver disease [35]. Despite that few authors have expressed concerns about the accuracy of FIB-4 [36], the European Association for the Study of the Liver has recently published an updated version of their guideline for the non-invasive diagnosis of a liver injury and recommends the use of FIB-4 as a first-line method for detecting patients with high probability of presenting significant liver disease [37]. The present study adds to the literature that categorizes FIB-4 as a reliable tool for estimating liver fibrosis in patients in whom the performance of a liver biopsy is unlikely [38].…”

Section: Discussionmentioning

confidence: 99%

Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder

Fuster

Garcia-Calvo

Farré

et al. 2021

JCM

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Background: The association between markers of inflammation (interleukin (IL)-6 and IL-10), monocyte activation (sCD163 and sCD14), and microbial translocation (lipopolysaccharide (LPS) and LPS binding protein) and liver fibrosis in patients with alcohol use disorder (AUD) and no overt liver disease is not well established. Methods: We studied patients admitted for treatment of AUD at two hospitals in Barcelona. Advanced liver fibrosis (ALF) was defined as FIB-4 > 3.25. Results: A total of 353 participants (76.3% male) were included and 94 (26.5%) had ALF. In adjusted correlation analyses, sCD163, sCD14, IL-6, IL-10, and LPS binding protein levels directly correlated with FIB-4 values (adjusted correlation coefficients 0.214, 0.452, 0.317, 0.204, and 0.171, respectively). However, LPS levels were inversely associated with FIB-4 (−0.283). All plasma marker levels in the highest quartile, except LPS, were associated with ALF (sCD163, sCD14, IL-6, IL-10, and LPS binding protein: adjusted odds ratio (aOR) 11.49 (95% confidence interval 6.42–20.56), 1.87 (1.11–3.16), 2.99 (1.79–5.01), 1.84 (1.11–3.16), and 2.13 (1.30–3.50), respectively). Conversely, LPS levels in the lowest quartile were associated with ALF (aOR 2.58 (1.48–4.58), p < 0.01). Conclusion: In AUD patients, plasma levels of the markers of inflammation, monocyte activation, and microbial translocation are associated with ALF.

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“…The elastography examination results revealed notable structural alterations in the liver, with an average stiffness measurement of 21.3 kPa (ranging from 14 to 25.7 kPa) and an interquartile range (IQR) to median ratio of 45.5% [21]. This stiffness value corresponds to the advanced stage of ALC (F4) on the widely recognized METAVIR scale [22] (Figure 2 and Table 2). Hepatic elastography, a non-invasive imaging technique, has proven to be a valuable tool in assessing liver fibrosis and ALC [20].…”

Section: Diagnostic Assessmentmentioning

confidence: 92%

“…The elastography results demonstrated a mean stiffness measurement of 5.70 kPa, which corresponds to non-significant fibrosis (F0-F1) on the METAVIR scale [22]. The stiffness range fell between 2.5 and 7 kPa, indicating minimal fibrotic changes within the liver (Figures 3 and 4, Table 3).…”

Section: Follow-up and Outcomesmentioning

confidence: 93%

“…The METAVIR scale [22], widely adopted for the histopathological assessment of liver fibrosis, classifies ALC into different stages based on the degree of fibrotic alterations. The F4 stage represents the most advanced form of ALC, characterized by the presence of extensive fibrosis and architectural distortion within the liver parenchyma.…”

Section: Diagnostic Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

REAC Reparative Treatment: A Promising Therapeutic Option for Alcoholic Cirrhosis of the Liver

Pereira,

Fontani

et al. 2023

JPM

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Alcoholic liver disease (ALD) is a significant global health concern associated with excessive alcohol consumption. ALD encompasses various liver conditions with complex pathogenesis and progression influenced by environmental, genetic, and epigenetic factors. Alcoholic cirrhosis of the liver (ALC) is particularly prevalent among socially disadvantaged individuals, and current pharmacotherapy options provide limited treatment. This study aims to explore the potential benefits of radio electric asymmetric conveyer (REAC) technology and its tissue optimization reparative treatment (TO-RPR) in managing ALC. The liver possesses remarkable regenerative capabilities closely tied to its bioelectrical properties. REAC TO-RPR is a novel biotechnological therapeutic approach that aims to enhance and expedite reparative processes in injured tissues by restoring disrupted cellular endogenous bioelectric fields. This study seeks to optimize understanding of REAC TO-RPR’s impact on liver function and clinical outcomes in ALC patients. By investigating the mechanisms underlying liver’s reparative abilities and evaluating the efficacy of REAC TO-RPR, this research aims to address the urgent need for improved interventions in managing ALC. The findings hold potential for developing innovative treatment approaches, improving patient outcomes, and reducing the societal and individual burden associated with ALC.

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Validation of a machine learning approach using FIB-4 and APRI scores assessed by the metavir scoring system: A cohort study

Cited by 5 publications

References 23 publications

Aspartate Aminotransferase–to–Platelet Ratio Index Suggestive of Liver Dysfunction Predicts Early Complications After Open Reduction Internal Fixation of Distal Radius Fractures

Aspartate Aminotransferase–to–Platelet Ratio Index Suggestive of Liver Dysfunction Predicts Early Complications After Open Reduction Internal Fixation of Distal Radius Fractures

Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder

REAC Reparative Treatment: A Promising Therapeutic Option for Alcoholic Cirrhosis of the Liver

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