Validation of a documentary on Chagas disease by a population living in an endemic area

Bianchi, Tanise Freitas; Jeske, Sabrina; Sartori, A M C; Grala, Ana Paula da Paz; Villela, Marcos Marreiro

doi:10.1590/1519-6984.228876

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…This supposition is corroborated by the fact that there has been a decrease in people’s knowledge on CD vectors and of the disease notification lately, as shown by a study conducted by Bianchi et al . 25 , who observed that older adults are more aware of the topic than youngsters.…”

Section: Discussionmentioning

confidence: 99%

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Bianchi

Jeske

Grala

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3 rd Regional Health Coordination (RHC) and to the 7 th RHC, whose headquarters are in Pelotas and Bage, respectively. The study was based on secondary data provided by the partnership between the Federal University of Pelotas, Rio Grande do Sul State (UFPel-RS) and the State Health Surveillance Center in RS (SCHS-RS). One thousand and four hundred triatomines were captured in the area supervised by the 3 rd RHC, mainly in Cangucu (37.7%), Piratini (22.4%) and Pinheiro Machado (15.1%), while, in the area supervised by the 7 th RHC, the largest number of triatomines was captured in Lavras do Sul (64.15%). In both areas, Triatoma rubrovaria (90.6%) and Panstrongylus tupynambai (7.4%) were the most common species. Most were captured inside households but T. cruzi -positive insects were not found in the period under study. The results of this study show that, in Southern Rio Grande do Sul State, there is still a high rate of triatomine household invasion and dispersal, mainly by T. rubrovaria . Thus, the entomological surveillance should be maintained with the participation of the population and further studies should be deepened in the area.

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Section: Discussionmentioning

confidence: 99%

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Bianchi

Jeske

Grala

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…However, it is important that the population is aware of the importance of the transmission of CD by its vectors, as the encounter of triatomines can occur, even if occasionally, inside residences present in metropolitan regions (Silva et al, 2020). Additionally, educational interventions may trigger actions that contribute to prevent parasitic diseases such as Chagas disease (Bianchi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

et al. 2021

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Chagas disease (CD) is considered a typical low-income population sickness of the developing countries in Latin America. Given the historical relevance of CD in individuals in southern Rio Grande do Sul (RS) State, Brazil, the aim of this study was to identify the knowledge of the CD and its vectors by cardiac patients, and the prevalence of anti-T cruzi antibodies in these individuals in Pelotas, city located in Rio Grande do Sul (RS) state, Brazil. The subjects with cardiac disease were submitted to a semi-structured questionnaire as well as two serological tests in order to detect anti-T. cruzi IgG antibodies. Of the individuals that born in municipalities showing the highest triatomine infestation rates in recent decades, 81.8% were able to recognize the vector insect (p = 0.0042; OR = 5.9), and 83.3% reported either themselves or someone in their families to have CD (p = 0.043, OR = 5.2). Of the 54 patients submitted to serological analysis, only 01 patient (1.9%) was positive for anti-T. cruzi antibodies, a 55 year old man from the rural area of Canguçu county. This study provides support for the evaluation to be extended to other cardiology centers, given the importance of Chagas disease in Brazil.

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“…Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis, which infects about six to seven million people worldwide, mostly in Latin America (WHO, 2020;Bianchi et al, 2021), considered a typical disease of low-income population developing countries (Dutra et al, 2021). In fact, vectorborne transmission is limited to areas of South, Central and North Americas (Bern, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics and expression analysis of the Xeroderma Pigmentosum complementation group C (XPC) of Trypanosoma evansi in Trypanosoma cruzi cells

et al. 2023

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Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its importance in other cellular processes. In this work, we studied NER proteins in Trypanosoma cruzi and Trypanosoma evansi, parasites of humans and animals respectively. We performed three-dimensional models of XPC proteins from T. cruzi and T. evansi and observed few structural differences between these proteins. In our tests, insertion of XPC gene from T. evansi (TevXPC) in T. cruzi resulted in slower cell growth under normal conditions. After cisplatin treatment, T. cruzi overexpressing its own XPC gene (TcXPC) was able to recover cell division rates faster than T. cruzi expressing TevXPC gene. Based on these tests, it is suggested that TevXPC (being an exogenous protein in T. cruzi) interferes negatively in cellular processes where TcXPC (the endogenous protein) is involved. This probably occurred due interaction of TevXPC with some endogenous molecules or proteins from T.cruzi but incapacity of interaction with others. This reinforces the importance of correctly XPC functioning within the cell.

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Validation of a documentary on Chagas disease by a population living in an endemic area

Cited by 5 publications

References 23 publications

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Current situation of Chagas disease vectors (Hemiptera, Reduviidae) in Southern Rio Grande do Sul State, Brazil

Seroprevalence of Chagas disease in Southern Brazilian cardiac patients and their knowledge about the parasitosis and vectors

Bioinformatics and expression analysis of the Xeroderma Pigmentosum complementation group C (XPC) of Trypanosoma evansi in Trypanosoma cruzi cells

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