Validation of a bioanalytical HPLC–UV method to quantify Α‐Bisabolol in rat plasma applied to pharmacokinetic pilot study with the drug nanoemulsion
Matheus Antônio da Hora Borges,
Jackeline Marley Santos de Araújo,
Laiz Campos Pereira
et al.
Abstract:Abstractα‐Bisabolol (α‐BIS) is a sesquiterpene alcohol present in chamomile essential oil [Chamomilla recutita (L.) Rauschert]. Despite its numerous pharmacological effects, its pharmacokinetics remain understudied. An analytical method capable of quantifying α‐BIS in plasma is crucial to enable pharmacokinetic analysis. Presently, only one study has quantified it using mass spectrometry. Administering α‐BIS requires a nanoemulsion for intravenous injection. This study aimed to develop and validate a bioanalyt… Show more
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