Validation of 3-Dimensional Speckle Tracking Imaging to Quantify Regional Myocardial Deformation

Seo, Yoshihiro; Ishizu, Tomoko; Enomoto, Yoshiharu; Sugimori, Haruhiko; Yamamoto, Masayoshi; Machino, Tomoko; Kawamura, Ryo; Aonuma, Kazutaka

doi:10.1161/circimaging.109.858480

Cited by 188 publications

(152 citation statements)

References 28 publications

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“…Speckle-tracking strain imaging has been demonstrated to be an appropriate method for the examination of global and regional LV functional properties (15,16), which was confirmed in the present study. In this study, it was found that changes in the peak value and time to peak value of certain strains accorded with the physiological characteristics of the left ventricle.…”

Section: Discussionsupporting

confidence: 83%

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

Sun

Wang

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the incremental value of resting three-dimensional speckle-tracking echocardiography (3D-STE) in the detection of early-stage left ventricular dysfunction in patients with coronary artery disease (CAD). A total of 110 patients suspected of having CAD were recruited. All patients underwent 3D-STE and coronary artery angiography (CAG). They were divided to a CAD group and a normal group according to the results of CAG. Using 3D-STE software, the peak values of longitudinal strain (LS), circumferential strain (CS), radial strain (RS) and area strain (AS) and the time to peak value of these strains (T-LS, T-CS, T-RS and T-AS) were measured. A receiver operator characteristic curve (ROC) was used to analyze the sensitivity of these strains for the diagnosis of CAD. ROC analysis indicated that T-LS and composite indices combining the peak strain value and time to peak of LS, CS and AS have diagnostic value for the early detection of CAD; the area under the curve (AUC) values were 0.667, 0.692, 0.621 and 0.672 respectively (P<0.005). The composite index of longitudinal strain demonstrated the highest diagnostic value for CAD with 62% sensitivity and 76% specificity. These results indicate that 3D-STE has incremental value for the diagnosis of CAD in patients at rest.

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Section: Discussionsupporting

confidence: 83%

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

Sun

Wang

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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“…A second, more popular approach is the use of optical flow methods. In the ultrasound society these are traditionally subdivided into either phase-based techniques applied on the radio-frequency data using correlation, time-or phase-shift techniques to estimate motion [2]; and block-matching techniques on Bmode data [3] [4]. A third approach is to use image registration techniques where the cardiac deformation field is parametrized using smooth basis functions [5][6] [7].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional myocardial strain estimation from volumetric ultrasound: Experimental validation in an animal model

Heyde

Jasaitytė

Bouchez

et al. 2011

2011 IEEE International Ultrasonics Symposium

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Abstract-Although real-time three-dimensional echocardiography has the potential to allow for more accurate assessment of global and regional ventricular dynamics compared to the more traditional two-dimensional ultrasound examinations, it still requires rigorous testing and validation against other accepted techniques should it breakthrough as a standard examination in routine clinical practice. Very few studies have looked at a validation of regional functional indices in an in-vivo context. The aim of the present study therefore was to validate a previously proposed 3D strain estimation-method based on elastic registration of subsequent volumes on a segmental level in an animal model. Volumetric images were acquired with a GE Vivid7 ultrasound system in five open-chest sheep instrumented with ultrasonic microcrystals. Radial ( RR ), longitudinal ( LL) and circumferential strain ( CC ) were estimated during four stages: at rest, during esmolol and dobutamine infusion, and during acute ischemia. Moderate correlations for LL (r=0.63; p<0.01) and CC (r=0.60; p=0.01) were obtained, whereas no significant radial correlation was found. These findings are comparable to the performance of the current state-of-the-art commercial 3D speckle tracking methods.

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“…Measures of regional volume or area change, [69][70][71] radial fractional shortening, 72 shape indices, 73 and strain from 3D speckle tracking [74][75][76] have been recently developed for 3DE. Our lab has developed a 3D measure of wall motion, three-dimensional fractional shortening (3DFS), which can accurately detect the size and location of a region with acute supply ischemia.…”

Section: Echocardiographymentioning

confidence: 99%

“…77 Other groups have developed methods for measuring myocardial strain from 3DE using speckle tracking, 75 and have proposed area strain as a measure that takes advantage of the 3D data and is more sensitive to mechanical abnormalities than circumferential or longitudinal strain. 76 Various studies have suggested that circumferential strain 65,93 and peak systolic strain rate 66,67 are effective for detecting wall motion abnormalities from 2D stress echo, while the 3DE-based measures area strain and 3DFS have not been evaluated for use during stress testing.…”

Section: Figure 38 Size Of ∆3dfs Abnormalitiesmentioning

confidence: 99%

“…To get a rough idea of how strain measured from speckle tracking would compare to ∆3DFS in this study, we performed a Monte Carlo simulation of expected speckle tracking strains based on our sonomicrometry measurements. We used the BlandAltman bias and standard deviation values available in literature for 2D 63 and 3D 75 speckle tracking for circumferential and longitudinal strain and 3D speckle tracking for area strain 76 vs. sonomicrometry to generate a probability distribution of speckle tracking measurements for each sonomicrometry measurement performed in the study. Table 4.4 details the average ROC analysis results from 1000 simulations.…”

Section: Application To Clinical Diagnosismentioning

confidence: 99%

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Regional Mechanics of Demand Ischemia During Cardiac Stress Testing

Parker

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Currently, the most effective non-invasive method for early diagnosis of coronary artery disease is the cardiac stress test. In this test, stress is induced by treadmill exercise or with a pharmacologic agent such as dobutamine, and myocardium with insufficient coronary flow reserve, usually caused by coronary stenosis, experiences an imbalance between oxygen supply and demand known as demand ischemia. This causes altered mechanical and electrical behavior that is often identified using cardiac imaging. The mechanical movement of the left ventricular (LV) wall, characterized clinically as "wall motion", is currently assessed qualitatively to identify abnormally-moving ischemic regions which may benefit from angioplasty. Advances in ultrasound and MRI may improve diagnosis by allowing more quantitative measures such as strain, wall thickening, or endocardial fractional shortening. However, little is understood about how these measures are affected by the severity of demand ischemia, coupling to adjacent myocardium, or the presence of previously-unrecognized myocardial infarction. A greater understanding of the factors that influence regional mechanics during stress testing would help determine the best way to detect the altered mechanics that indicate demand ischemia and coronary stenosis. The goal of this dissertation is to understand how regional demand ischemia affects regional mechanics and apply that knowledge to improve clinical stress testing.A finite element model of the heart was used to examine how reduced force generation in the ischemic region, ischemic region size, and coupling to myocardium with increased contractility separately and jointly impact various measures of regional mechanics. Area strain and a measure of wall motion developed in our lab, threeiv dimensional fractional shortening (3DFS), were most sensitive to reduced force generation, while radial strain was affected most by the contractility of remote myocardium. The model also predicted that a novel measure of wall motion bulging, dyskinesia severity index (DSI), can separate infarcts from demand ischemia during stress testing. The ability of strain and 3DFS to detect a critical stenosis was evaluated in experimental canine dobutamine stress tests. The three-dimensional (3D) measures of area strain and 3DFS detected critical stenoses better than two-dimensional (2D) strain. Finally, 3DFS measured during clinical stress testing in patients at low risk for coronary artery disease displayed low variability, suggesting 3DFS may be effective for detecting demand ischemia in patients.Another application in which the cardiac mapping techniques described here could improve treatment is in evaluating cardiac resynchronization therapy (CRT) nonresponders, which compromise 30-40% of CRT patients. The relationship between LV lead location and scar or regional mechanical function measured from pre-CRT cardiac imaging likely has an important impact on CRT response. A method to reconstruct the 3D coordinates of the lead from 2D fluoroscopic i...

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Validation of 3-Dimensional Speckle Tracking Imaging to Quantify Regional Myocardial Deformation

Cited by 188 publications

References 28 publications

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

Three-dimensional myocardial strain estimation from volumetric ultrasound: Experimental validation in an animal model

Regional Mechanics of Demand Ischemia During Cardiac Stress Testing

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