Validation of 2 Depression Screening Tools in Dialysis Patients

Watnick, Suzanne; Wang, Pei Li; Demadura, T; Ganzini, Linda

doi:10.1053/j.ajkd.2005.08.006

Cited by 282 publications

(325 citation statements)

References 20 publications

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“…Our finding is that the 7.8% prevalence of depression in HD patients is lower compared to that found in most studies in which the prevalence of HD patients experiencing depression is estimated at around 20% to 30%. [2][3][4] Nonetheless, our prevalence rate is close to the 9.9% rate of depression found in a Brazilian study that included patients from Porto Alegre, a city located in a richer region in southern Brazil. 18 Populations from regions with a higher socioeconomic level usually include a larger number of diabetic and elderly patients undergoing chronic hemodialysis.…”

Section: Discussionmentioning

confidence: 81%

“…1 Most studies report that depression is prevalent in 20% to 30% of patients in hemodialysis (HD). [2][3][4] In diagnosing depression, this discrepancy in prevalence can certainly be attributed to the use of different study populations and methods. One important variable influencing the prevalence of depression is the sociocultural environment.…”

Section: Introductionmentioning

confidence: 99%

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Depression and quality of life of hemodialysis patients living in a poor region of Brazil

Santos

2011

Rev. Bras. Psiquiatr.

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Objective: To determine the correlation between depression and quality of life (QOL) of patients in hemodialysis (HD). Method: One hundred and sixty six patients over 18 years of age who had been in HD for at least three months and had no history of transplant. QOL was assessed using the SF-36. To categorize depression, a score ≥ 10 was used on the 10-item version of the Center for Epidemiologic Studies Depression Scale (CES-D). Comparisons between depressed and nondepressed patients were performed using the chi-square test, Student's t-test, and Mann-Whitney test. Multiple regression was performed to assess the predictive variables of patients' QOL. Results: Symptoms of depression were found in 13 (7.8%) patients. The only variable that differed among depressed patients was QOL. Depressed patients presented lower scores in vitality (40.7 vs. 57.3; p = 0.010), role-emotional (25.6 vs. 62.5

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Depression and quality of life of hemodialysis patients living in a poor region of Brazil

Santos

2011

Rev. Bras. Psiquiatr.

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“…Approaches to diagnosis and treatment of these conditions as part of the hemodialysis experience are necessary. Our study builds upon earlier work which tended to use either a check list consisting of single-item symptoms, such as fatigue and pain, using instruments such as the Dialysis Symptoms Index (8) or specialized instruments to measure a single condition in great detail (5,7). Cognition has been measured during dialysis treatment in some studies using only the MMSE (24), an instrument that identifies some, but not all aspects of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Conditions Addressed by Hemodialysis Guidelines and Non-ESRD-Specific Conditions Affecting Quality of Life

Leinau

Murphy

Bradley

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Persons with ESRD identify non-disease-specific conditions as negatively affecting their quality of life. It is unknown how these non-ESRD-specific conditions correlate with each other and with ESRD-specific conditions such as anemia, renal osteodystrophy, dialysis access, and dialysis adequacy. The objectives of this study were to determine the prevalence and inter-relatedness of selected conditions among persons receiving hemodialysis and to analyze the relationship between non-ESRD-specific and ESRD-specific conditions. Design, setting, participants, & measurements: This was an observational cohort study of persons with ESRD that included standardized assessments for pain, fatigue, depression, cognitive impairment, and impaired physical performance. The study was conducted at three dialysis clinics in one urban geographic area. Of the 134 persons who met exclusion criteria, 25 declined participation, yielding a sample size of 109.Results: Pain was present in >81% of participants, fatigue and impaired physical performance in >60% participants, and cognitive impairment and depression in >25% of participants. Pain, fatigue, and depression were highly correlated, but had no correlation with use of a catheter for access, hemoglobin (Hgb), intact parathyroid hormone (iPTH), phosphorous, or Kt/V values outside of the range of guidelines. There was a modest correlation between cognitive function and both Hgb and iPTH.Conclusions: Non-ESRD-specific conditions such as fatigue, pain, and depression are as prevalent as ESRD-specific conditions, and the magnitude of the correlations between the non-ESRD-specific conditions is greater than the correlations between non-ESRD-specific and ESRD-specific conditions. Current guidelines may be failing to address a substantial component of the disease burden for persons with ESRD.

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“…Comorbid conditions were assessed using the modified Charlson Comorbidity Index (14). Depressive symptoms were defined as a score Ն15 on the Beck Depression Inventory (15,16). Quality of life was assessed with the SF-36 Physical Health Component and Mental Health Component scales (17).…”

Section: Explanatory Variables and Covariatesmentioning

confidence: 99%

Prevalence and Correlates of Cognitive Impairment in Hemodialysis Patients

Tamura

Larive²,

Unruh³

et al. 2010

Clinical Journal of the American Society of Nephrology

176

151

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Background and objectives: Cognitive impairment is common among persons with ESRD, but the underlying mechanisms are unknown. This study evaluated the prevalence of cognitive impairment and association with modifiable ESRD-and dialysis-associated factors in a large group of hemodialysis patients.Design, setting, participants, & measurements: Cross-sectional analyses were conducted on baseline data collected from 383 subjects participating in the Frequent Hemodialysis Network trials. Global cognitive impairment was defined as a score <80 on the Modified Mini-Mental State Exam, and impaired executive function was defined as a score >300 seconds on the Trailmaking B test. Five main categories of explanatory variables were examined: urea clearance, nutritional markers, hemodynamic measures, anemia, and central nervous system (CNS)-active medications.Results: Subjects had a mean age of 51.6 ؎ 13.3 years and a median ESRD vintage of 2.6 years. Sixty-one subjects (16%) had global cognitive impairment, and 110 subjects (29%) had impaired executive function. In addition to several nonmodifiable factors, the use of H1-receptor antagonists and opioids were associated with impaired executive function. No strong association was found between several other potentially modifiable factors associated with ESRD and dialysis therapy, such as urea clearance, proxies of dietary protein intake and other nutritional markers, hemodynamic measures, and anemia with global cognition and executive function after adjustment for case-mix factors.Conclusions: Cognitive impairment, especially impaired executive function, is common among hemodialysis patients, but with the exception of CNS-active medications, is not strongly associated with several ESRD-and dialysis-associated factors.

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Validation of 2 Depression Screening Tools in Dialysis Patients

Cited by 282 publications

References 20 publications

Depression and quality of life of hemodialysis patients living in a poor region of Brazil

Depression and quality of life of hemodialysis patients living in a poor region of Brazil

Relationship between Conditions Addressed by Hemodialysis Guidelines and Non-ESRD-Specific Conditions Affecting Quality of Life

Prevalence and Correlates of Cognitive Impairment in Hemodialysis Patients

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