Validation and reproducibility of aortic pulse wave velocity as assessed with velocity‐encoded MRI

Abstract

Purpose: To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV MRI ) with PWV determined from invasive intra-aortic pressure measurements (PWV INV ) and to test the reproducibility of the measurement by MRI. Materials and Methods:PWV MRI was compared with PWV INV in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWV MRI was tested in 10 healthy volunteers who underwent repeated measurement of PWV MRI at a single occasion. Velocity-encoded MRI was performed on all participants to assess PWV MRI in the total aorta (Ao total ), the proximal aorta (Ao prox ), and the distal aorta (Ao dist ). Conclusion: MRI assessment of aortic pulse wave velocity shows good agreement with invasive pressure measurements and can be determined with high reproducibility. Results

Pulse wave velocity with 4D flow MRI: Systematic differences and age-related regional vascular stiffness

“…Table 3. Age-related descending aortic PWV in the present study compared to previous studies with higher temporal resolution methods 13,16 . 4.3 ± 0.6 Taviani et al 16 1D FVE MRI 3.5 ~30* 4.2 ± 0.7 Taviani et al 16 1D FVE MRI 3.5 ~50* 5.9 ± 0.9 Present study 4D flow MRI 39-43 58 ± 2 6.4 ± 1.7 Taviani et al 16 1D FVE MRI 3.5 ~70* 8.0 ± 1.3 * Approximate mean age calculated as the average of the age ranges reported by Taviani et al 16 .…”

“…The invasiveness of the gold standard technique and the limitations of the current clinical approach have prompted the development of alternative means of estimating PWV 5 . Notably, MRI has evolved as a promising method [6][7][8][9][10][11][12][13][14][15][16][17][18] The merits of MRI for the estimation of PWV include the capabilities of obtaining: 1) angiographic images that permit accurate determination of vascular distance and 2) an arbitrary number of velocity or flow waveforms at any location in the body. MRbased PWV estimation has primarily been done with 2D cine phase-contrast (PC) MRI 6,9-11, 13 .…”

“…Notably, MRI has evolved as a promising method [6][7][8][9][10][11][12][13][14][15][16][17][18] The merits of MRI for the estimation of PWV include the capabilities of obtaining: 1) angiographic images that permit accurate determination of vascular distance and 2) an arbitrary number of velocity or flow waveforms at any location in the body. MRbased PWV estimation has primarily been done with 2D cine phase-contrast (PC) MRI 6,9-11, 13 . Another method that has been explored is 1D Fourier velocity encoding (FVE) MRI, which permits high temporal resolution but is limited to applications in straight vessel segments 7,8,15,16 .…”

Prognostic Value of Aortic Stiffness in Patients After ST‐Elevation Myocardial Infarction

“…In the study presented in this article, aortic PWV was measured using the CMR‐derived “transit‐time” method, which was described in detail previously 4. It provides a valid and highly reproducible technique and shows good agreement with invasive catheter measurements 19. Moreover, in the study presented in this article, local aortic distensibility coefficients as measures of local aortic stiffness were calculated.…”

Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study

“…The transit time was estimated from the systolic up-slope portion of the velocity waves using an automated method based on a least squares minimization technique used in previous studies for the evaluation of the effect of coarctation repair [20] and aging [21] on CMR aortic stiffness indices. Other methods based on the foot-to-foot [18] or on the cross-correlation [32] were used to estimate the transit time. Similar to the foot-to-foot approaches, the systolic up-slope was considered in our method rather than the entire curve as proposed in the cross-correlation methods.…”