Validation and Feasibility of an Automated System for the Assessment of Vascular Structure and Mechanical Properties in the Digital Arteries: An Ultrahigh-Frequency Ultrasound Study

Poli, Federica; Fortier, Catherine; Khettab, Hakim; Faita, Francesco; Vitali, Saverio; Aringhieri, Giacomo; Ghiadoni, Lorenzo; Taddei, Stefano; Amar, Laurence; Lorthioir, Aurélien; Boutouyrie, P.; Bruno, Rosa María

doi:10.1016/j.ultrasmedbio.2021.12.008

Cited by 2 publications

(1 citation statement)

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“…Three end-diastolic frames were selected for each clip: in each frame, global wall thickness, as well as inner and outer layer thickness (leading edge to leading edge), were measured manually on 3 different points, by using a graphic user interface build in Matlab. 32 Systolo-diastolic stroke change in radial lumen (radial distension) was measured by the same automated software used for carotid (Carotid Studio, Cardiovascular Suite 3.0; Quipu srl, Pisa, Italy) and radial distensibility coefficient obtained by the aforementioned formula. Oscillometric brachial pulse pressure was used for radial distensibility coefficient calculation.…”

Section: Methodsmentioning

confidence: 99%

Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study

et al. 2022

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Fibromuscular dysplasia (FMD), a nonatherosclerotic, noninflammatory disease of medium-sized arteries, is an underdiagnosed disease. We investigated the urinary proteome and developed a classifier for discrimination of FMD from healthy controls and other diseases. We further hypothesized that urinary proteomics biomarkers may be associated with alterations in medium-sized, but not large artery geometry and mechanics. The study included 33 patients with mostly multifocal, renal FMD who underwent in depth arterial exploration using ultra-high frequency ultrasound. The cohort was separated in a training set of 23 patients with FMD from Belgium and an independent test set of 10 patients with FMD from Italy. For each set, controls matched 2:1 were selected from the Human Urinary Proteome Database. The specificity of the classifier was tested in 700 additional controls from general population studies, patients with chronic kidney disease (n=66) and coronary artery disease (n=31). Three hundred thirty-five urinary peptides, mostly related to collagen turnover, were identified in the training cohort and combined into a classifier. When applying in the test cohort, the area under the receiver operating characteristic curve was 1.00, 100% specificity at 100% sensitivity. The classifier maintained a high specificity in additional controls (98.3%), patients with chronic kidney (90.9%) and coronary artery (96.8%) diseases. Furthermore, in patients with FMD, the proteomic score was positively associated with radial wall thickness and wall cross-sectional area. In conclusion, a proteomic score has the potential to discriminate between patients with FMD and controls. If confirmed in a wider and more diverse cohort, these findings may pave the way for a noninvasive diagnostic test of FMD.

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Section: Methodsmentioning

confidence: 99%