Validation and Application of Dual-Energy X-ray Absorptiometry to Measure Bone Mineral Density in Rabbit Vertebrae

Norris, Shane A.; Pettifor, John M.; Gray, Dave A.; Biscardi, A.; Buffenstein, Rochelle

doi:10.1385/jcd:3:1:049

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…In addition, the fact that BMD is expressed as BMC divided by the projected two-dimensional area of the bone, whereas the volumetric density accounts for bone volume may also have contributed to limit these R 2 values. Although, the Pearson relations between in vivo BMC and ash weight and in vivo BMD and volumetric density from non-overlapping bones such as vertebrae [14] were not any better than the present ones and no difference in BMD, BMC and breaking strength from Mc was observed between the left and right front foot from pigs [16].…”

Section: Potential Of Dual Energy X-ray Absorptiometry Technology Witcontrasting

confidence: 73%

“…Dual energy X-ray absorptiometry technology enables a labor friendly and rapid measurement of bone mineralization characteristics expressed as BMC and BMD. Previous studies have shown that the linear relationship between BMC or BMD and chemical (ash) and mechanical properties (volumetric density, maximal load) of dissected bones were acceptable to excellent [14][15][16]. In the present study, DXA measures from a non-dissected foot were compared with the chemical and mechanical properties of dissected Mc to verify if the labor for dissection, chemical analysis, and physical measures can be saved.…”

Section: Potential Of Dual Energy X-ray Absorptiometry Technology Witmentioning

confidence: 94%

“…Dual energy X-ray absorptiometry (DXA) technology has progressively been adopted to assess body composition in growing pigs [12,13]. It represents an alternative non-invasive technology to easily and rapidly assess bone mineral content (BMC) and density (BMD) from selected bones [14][15][16]. Thus, the DXA BMC and BMD from non-dissected easily accessible animal part, such as the front foot may be an alternative to chemical and mechanical tests from dissected bones.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Calcium to Digestible Phosphorus Ratio for Optimal Growth Performance and Bone Mineralization in Growing and Finishing Pigs

Schlegel

Gutzwiller

2020

Animals

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Within the context of maximizing the use of dietary phosphorus, a growing-finishing pig study was conducted to determine the optimal total dietary calcium (Ca) to digestible phosphorus (dP) ratio and to verify the possibility of mineral phosphate removal during the finishing period on growth performance and mineral status. The potential for replacing chemical and mechanical bone properties by dual energy X-ray absorptiometry (DXA) measures on non-dissected feet was also verified. Three Ca to dP ratios (2.2:1, 2.5:1 and 2.8:1) within two dP levels (P+, P–) were fed during 91 days to 84 pigs. The grower and finisher P+ diets contained 3.0 and 2.4 and P– diets contained 2.5 and 1.7 g dP/kg, respectively. Growth performance and blood serum mineral content were independent of treatments, except that 2.2:1 impaired finisher feed conversion ratio compared to 2.5:1 and 2.8:1. Urinary P concentration increased by 37% in 2.2:1 compared to 2.5:1 and 2.8:1. Maximal load on bone and DXA mineral density were reduced in 2.2:1 compared to 2.8:1. Bone ash and volumetric density were reduced in 2.2:1 and 2.5:1 compared to 2.8:1. Diet P– reduced bone ash, maximal load, volumetric density and DXA bone mineral content and density. No interaction was observed between Ca and dP level. Therefore, 2.2:1 was insufficient for an efficient metabolic use of P, 2.5:1 was sufficient to maximize growth performance and 2.8:1 further improved bone mineralization. Increasing dietary Ca did not impair bone zinc content. Diets P– without supplemented mineral phosphates during the finisher period resulted, per pig, in a decrease of its use by 65% and of the calculated P excretion by 41%, without impaired growth performance. Finally, DXA data responded to dietary treatments as did labor intensive chemical and mechanical bone properties.

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Section: Potential Of Dual Energy X-ray Absorptiometry Technology Witcontrasting

confidence: 73%

Section: Potential Of Dual Energy X-ray Absorptiometry Technology Witmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Calcium to Digestible Phosphorus Ratio for Optimal Growth Performance and Bone Mineralization in Growing and Finishing Pigs

Schlegel

Gutzwiller

2020

Animals

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“…Although there are differences between human and rabbit bone compositions and densities, Wang et al (26) reported some similarities in BMD and fracture resistance of mid-diaphyseal bone between rabbits and humans. In another study, DXA with small animal software was used to measure BMD in rabbit vertebrae, confirming that QDR-4500 (Hologic, Waltham, MA) can be used to yield precise and accurate measurements of rabbit spine BMD (18). …”

Section: Discussionmentioning

confidence: 78%

“…The most common method of measuring bone mass is dual-energy x-ray absorptiometry (DXA), and it is a reliable and noninvasive method (18–20). Surgeons can predict bone health and fracture risk and can measure bone response to osteoporosis treatment by using DXA evaluation.…”

mentioning

confidence: 99%

Effect of Endodontic Cement on Bone Mineral Density Using Serial Dual-energy X-ray Absorptiometry

Saghiri

Orangi

Tanideh

et al. 2014

Journal of Endodontics

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Introduction Materials with new compositions were tested in order to develop dental materials with better properties. Calcium silicate–based cements, including white mineral trioxide aggregate (WMTA), may improve osteopromotion because of their composition. Nano-modified cements may help researchers produce ideal root-end filling materials. Serial dual-energy x-ray absorptiometry measurement was used to evaluate the effects of particle size and the addition of tricalcium aluminate (C3A) to a type of mineral trioxide aggregate–based cement on bone mineral density and the surrounding tissues in the mandible of rabbits. Methods Forty mature male rabbits (N = 40) were anesthetized, and a bone defect measuring 7 × 1 × 1 mm was created on the semimandible. The rabbits were divided into 2 groups, which were subdivided into 5 subgroups with 4 animals each based on the defect filled by the following: Nano-WMTA (patent application #13/211.880), WMTA (as standard), WMTA without C3A, Nano-WMTA + 2% Nano-C3A (Fujindonjnan Industrial Co, Ltd, Fujindonjnan Xiamen, China), and a control group. Twenty and forty days postoperatively, the animals were sacrificed, and the semimandibles were removed for DXA measurement. Results The Kruskal-Wallis test followed by the Mann-Whitney U test showed significant differences between the groups at a significance level of P < .05. P values calculated by the Kruskal-Wallis test were .002 for bone mineral density at both intervals and P20 day = .004 and P40 day = .005 for bone mineral content. Conclusions This study showed that bone regeneration was enhanced by reducing the particle size (nano-modified) and C3A mixture. This may relate to the existence of an external supply of minerals and a larger surface area of nano-modified material, which may lead to faster release rate of Ca2+, inducing bone formation. Adding Nano-C3A to Nano-WMTA may improve bone regeneration properties.

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Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits

et al. 2005

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Validation and Application of Dual-Energy X-ray Absorptiometry to Measure Bone Mineral Density in Rabbit Vertebrae

Cited by 8 publications

References 13 publications

Dietary Calcium to Digestible Phosphorus Ratio for Optimal Growth Performance and Bone Mineralization in Growing and Finishing Pigs

Dietary Calcium to Digestible Phosphorus Ratio for Optimal Growth Performance and Bone Mineralization in Growing and Finishing Pigs

Effect of Endodontic Cement on Bone Mineral Density Using Serial Dual-energy X-ray Absorptiometry

Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits

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