Validating Lung Models Using the ASL 5000 Breathing Simulator

Dexter, Amanda; McNinch, Neil L.; Kaznoch, Destiny; Volsko, Teresa A

doi:10.1097/sih.0000000000000277

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…18 A recent paper by Arnal et al 19 has addressed this issue and provided data for constructing standardized linear (passive) adult respiratory system models for simulation-based ventilator evaluations. Dexter et al 20 have published similar data for pediatric models.…”

Section: Realistic Simulation Parametersmentioning

confidence: 78%

Simulation-Based Evaluation of Mechanical Ventilators

Chatburn

2018

Respir Care

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Section: Realistic Simulation Parametersmentioning

confidence: 78%

Simulation-Based Evaluation of Mechanical Ventilators

Chatburn

2018

Respir Care

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“…As we worked with a ventilator, we had to simulate the patients. For this purpose, we have used an active lung simulator, such as the ASL 5000 [42], or a passive mechanical one. After the execution of the integration testing activities, for each one of the test cases, we have reported the outcomes in Integration Test Procedure and Integration Test Report documents.…”

Section: ) Importance Of Testingmentioning

confidence: 99%

Lessons Learned from the Development of a Mechanical Ventilator for COVID-19

Bombarda

Bonfanti

Galbiati

et al. 2021

2021 IEEE 32nd International Symposium on Software Reliability Engineering (ISSRE)

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During the COVID-19 pandemic, many researchers all over the world have offered their time and competencies to face the heavy consequences of the disease. This is the case of a group of physicists, engineers, and physicians that around the middle of March 2020 started to develop a simplified mechanical lung ventilator, called MVM (Mechanical Ventilator Milano), to answer the high request of ventilators for Acute Respiratory Distress Syndrome (ARDS) in intensive care units. A prototype was ready in around one month.Since medical software malfunctions can lead to injuries or death of patients, before marketing MVM ventilators and distributing them in hospitals, software certification in accordance with the IEC 62304 standard was mandatory to guarantee system reliability. The team was then complemented by computer scientists specifically devoted to this task. The software reengineering process, which lasted around two months from the end of the prototype, brought to a strong re-implementation of the device software components, which involved all the stakeholders in a continuous integration setting.In this paper, we report the experience of the MVM control SW re-engineering necessary to show evidence that the SW adheres to the standards and to consequently obtain the certification. We share results and lessons learned from this social project, where more than 100 volunteer researchers worked towards software certification at the extreme of their strength to get a real device finished in a rush since strongly required to support physicians in treating COVID-19 patients.

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“…The latter difference was caused by the fact that Kung et al proposed a new approach to coupling the numerical and physical components, and therefore they wanted to test it. The original, hardware-in-the-loop approach proposed by Pillon et al [6] and Verbraak et al [7] has been commonly used by several authors (e.g., [37][38][39][40]). According to this approach, a change in the physical component creates the corresponding reaction of the numerical component and vice versa.…”

Section: Approaches To Cardiovascular and Respiratory Systems Modellingmentioning

confidence: 99%

Virtual and Artificial Cardiorespiratory Patients in Medicine and Biomedical Engineering

et al. 2022

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Recently, ‘medicine in silico’ has been strongly encouraged due to ethical and legal limitations related to animal experiments and investigations conducted on patients. Computer models, particularly the very complex ones (virtual patients—VP), can be used in medical education and biomedical research as well as in clinical applications. Simpler patient-specific models may aid medical procedures. However, computer models are unfit for medical devices testing. Hybrid (i.e., numerical–physical) models do not have this disadvantage. In this review, the chosen approach to the cardiovascular system and/or respiratory system modeling was discussed with particular emphasis given to the hybrid cardiopulmonary simulator (the artificial patient), that was elaborated by the authors. The VP is useful in the education of forced spirometry, investigations of cardiopulmonary interactions (including gas exchange) and its influence on pulmonary resistance during artificial ventilation, and explanation of phenomena observed during thoracentesis. The artificial patient is useful, inter alia, in staff training and education, investigations of cardiorespiratory support and the testing of several medical devices, such as ventricular assist devices and a membrane-based artificial heart.

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Validating Lung Models Using the ASL 5000 Breathing Simulator

Abstract: Inconsistencies occurred with the models constructed on the ASL 5000. It was deemed accurate for the study purposes. It is therefore essential to test models and evaluate magnitude of differences before use.

Cited by 8 publications

References 20 publications

Simulation-Based Evaluation of Mechanical Ventilators

Simulation-Based Evaluation of Mechanical Ventilators

Lessons Learned from the Development of a Mechanical Ventilator for COVID-19

Virtual and Artificial Cardiorespiratory Patients in Medicine and Biomedical Engineering

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