Validating an image-based fNIRS approach with fMRI and a working memory task

Wijeakumar, Sobanawartiny; Huppert, Theodore J.; Magnotta, Vincent A.; Buss, Aaron T.; Spencer, John P.

doi:10.1016/j.neuroimage.2016.12.007

Cited by 69 publications

(72 citation statements)

References 80 publications

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“…We relied on methodology previously developed and validated with fMRI to combine the sensitivity profiles with channel-specific beta coefficients to generate voxel-wise estimates of HbO and HbR activation for each condition and participant (Wijeakumar et al, 2017). Briefly, the relationship between the hemodynamic response (beta coefficients from the channel-specific GLM described in section 2.3.2.)…”

Section: Image Reconstructionmentioning

confidence: 99%

“…To investigate these questions, we used a recently validated methodology with fNIRS to obtain voxel-wise measures of brain activation, enabling direct comparisons with the fMRI literature (Wijeakumar et al, 2017(Wijeakumar et al, , 2015. Previous work has used fNIRS to explore the neural mechanisms that underlie age-related decline in working memory (Vermeij et al, 2016(Vermeij et al, , 2014(Vermeij et al, , 2012.…”

Section: Fnirs Reveals Comparable Modulation Of Vwm Across Load and Cmentioning

confidence: 99%

“…fNIRS is an optical imaging technique where near-infrared light of two different wavelengths is shone through tissue and is selectively absorbed by oxy-(HbO) and deoxy-(HbR) hemoglobin. fNIRS has been used to explore neural function underlying a wide range of sensory (Bortfeld et al, 2007;Chen et al, 2015;Plichta et al, 2011;Wijeakumar et al, 2012), motor (Gagnon et al, 2012;Huppert et al, 2006) and cognitive functions such as working memory, response inhibition, and task-switching (Cutini et al, 2008;Rodrigo et al, 2014;Wijeakumar et al, 2017). fNIRS is a convenient technique for investigating brain function in response to VWM processing because the regions of interest (ROIs) are near the cortical surface.…”

mentioning

confidence: 99%

“…fNIRS is also cheaper than fMRI, making intensive study of age-related decline more feasible, and older adults do not have to remain completely still in a supine position for lengthy periods of time. Moreover, recent innovations in fNIRS analyses allow us to obtain voxel-wise measures of functional activation that can be directly compared to fMRI data (Wijeakumar et al, 2017(Wijeakumar et al, , 2015. …”

mentioning

confidence: 99%

“…These volumes were converted into 3D surface meshes using HOMER2. We relied on the procedures used in Wijeakumar et al (2017).Scalp landmarks and probe geometry for each participant were digitized using a Polhemus Patriot Motion Sensor. These points were projected onto each participant's head atlas using a relaxation algorithm (AtlasViewerGUI -available within HOMER2: www.nmr.mgh.harvard.edu/PMI/resources/Homer2).…”

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Modulating perceptual complexity and load reveals degradation of the visual working memory network in ageing

2017

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Previous neuroimaging studies have reported a posterior to anterior shift of activation in ageing (PASA). Here, we explore the nature of this shift by modulating load (1,2 or 3 items) and perceptual complexity in two variants of a visual working memory task (VWM): a 'simple' color and a 'complex' shape change detection task. Functional near-infrared spectroscopy (fNIRS) was used to record changes in activation in younger (N=24) and older adults (N=24). Older adults exhibited PASA by showing lesser activation in the posterior cortex and greater activation in the anterior cortex when compared to younger adults. Further, they showed reduced accuracy at loads 2 and 3 for the simple task and across all loads for the complex task. Activation in the posterior and anterior cortices was modulated differently for younger and older adults. In older adults, increasing load in the simple task was accompanied by decreasing activation in the posterior cortex and lack of modulation in the anterior cortex, suggesting the inability to encode and/or maintain representations without much aid from higher-order centers. In the complex task, older adults recruited verbal working memory areas in the posterior cortex, suggesting that they used adaptive strategies such as labelling the shape stimuli. This was accompanied by reduced activation in the anterior cortex reflecting the inability to exert top-down modulation to typical VWM areas in the posterior cortex to improve behavioral performance. IntroductionVisual working memory (VWM) is a short term storage system for visual information that is critical for at least two central aspects of cognition -for the comparison of percepts that cannot be simultaneously foveated and for identifying changes in the world when they occur (Luck and Vogel, 1997). As a result, VWM is central to adaptive functions such as navigation, driving, reading, and so on. Healthy VWM processing is critical throughout the human life span, and deficits in VWM processing have serious consequences for performance during early development and late adulthood.In healthy ageing, there are marked changes in this cognitive system. Decline in VWM is reported to start as early as in the fourth decade of life with a drop of 0.20 2 items per decade in both verbal and spatial working memory (Salthouse 1994). Although these data suggest a dramatic decline in working memory function, other factors might also play a role: factors such as deconditioning of physiological processes following inactivity, arthritis, and declining motor abilities can affect behavioral measures such as accuracy and reaction times. One way to move beyond motoric deficits is to investigate brain function alongside behavior in younger and older adults.Studies of WM using functional magnetic resonance imaging (fMRI) implicate a distributed cortical network that spans the frontal, parietal, and temporo-occipital cortices (Druzgal and D'Esposito, 2003;Learmonth et al., 2002;Linden et al., 2003;Ma et al., 2014;Pessoa and Ungerleider, 2004;Postle, 2015;R...

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Section: Image Reconstructionmentioning

confidence: 99%

Section: Fnirs Reveals Comparable Modulation Of Vwm Across Load and Cmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Modulating perceptual complexity and load reveals degradation of the visual working memory network in ageing

2017

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Evaluation of a personalized functional near infra‐red optical tomography workflow using maximum entropy on the mean

Cai

Uji

Aydın

et al. 2021

Human Brain Mapping

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Mapping brain function in adults and young children during naturalistic viewing with high‐density diffuse optical tomography

Tripathy,

Fogarty,

Svoboda

et al. 2024

Human Brain Mapping

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Human studies of early brain development have been limited by extant neuroimaging methods. MRI scanners present logistical challenges for imaging young children, while alternative modalities like functional near‐infrared spectroscopy have traditionally been limited by image quality due to sparse sampling. In addition, conventional tasks for brain mapping elicit low task engagement, high head motion, and considerable participant attrition in pediatric populations. As a result, typical and atypical developmental trajectories of processes such as language acquisition remain understudied during sensitive periods over the first years of life. We evaluate high‐density diffuse optical tomography (HD‐DOT) imaging combined with movie stimuli for high resolution optical neuroimaging in awake children ranging from 1 to 7 years of age. We built an HD‐DOT system with design features geared towards enhancing both image quality and child comfort. Furthermore, we characterized a library of animated movie clips as a stimulus set for brain mapping and we optimized associated data analysis pipelines. Together, these tools could map cortical responses to movies and contained features such as speech in both adults and awake young children. This study lays the groundwork for future research to investigate response variability in larger pediatric samples and atypical trajectories of early brain development in clinical populations.

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Validating an image-based fNIRS approach with fMRI and a working memory task

Cited by 69 publications

References 80 publications

Modulating perceptual complexity and load reveals degradation of the visual working memory network in ageing

Modulating perceptual complexity and load reveals degradation of the visual working memory network in ageing

Evaluation of a personalized functional near infra‐red optical tomography workflow using maximum entropy on the mean

Mapping brain function in adults and young children during naturalistic viewing with high‐density diffuse optical tomography

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