Validated Stability-Indicating Method for Alendronate Sodium Employing Zwitterionic Hydrophilic Interaction Chromatography Coupled with Charged Aerosol Detection

Recent applications of hydrophilic interaction liquid chromatography in pharmaceutical analysis

“…Following that, according to the difference kind of the detected targets, HILIC applied for chemical drug analysis in formulation and related matrices is summarized. Determination of APIs in complicated formulation is important for the QC of chemical drug in pharmaceutical industry, and various related researches have been proposed through HILIC coupled detection system [83][84][85][86]. In powder for intravenous injection, ␤-lactam antibiotics imipenem, and another active compound cilastatin sodium were determined simultaneously in the presence of degradation product thienamycin [83].…”

“…In general, using HPLC with any of the aerosol‐based detectors in the HILIC mode can be a good alternative to provide qualitative and quantitative information for polar analytes that have weak UV chromophores. In tablet formulations, the drug for osteoporosis alendronate sodium was also determined by CAD . The developed method was optimized in terms of chromatographic and detector parameters to achieve good peak shape with optimum resolution, and was found to be suitable for routine estimation of alendronate sodium and its related compounds in a marketed formulation.…”