Validated spectrophotometric methods for simultaneous determination of Omeprazole, Tinidazole and Doxycycline in their ternary mixture

Lotfy, Hayam M.; Hegazy, Maha A.; Mowaka, Shereen; Mohamed, Ekram H.

doi:10.1016/j.saa.2015.07.106

Cited by 34 publications

(15 citation statements)

References 19 publications

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“…Literature also revealed the quantitative analysis of Chloramphenicol, Dexamethasone sodium phosphate and Tetryzoline HCl [21] in eye drops using P-factor method. Simultaneous estimation of Sitagliptin phosphate and metformin HCl [17], Omeprazole, Tinidazole and Doxycycline [22] in dosage forms were also reported by this method.…”

Section: Applicationsmentioning

confidence: 86%

“…This novel method was applied for the analysis of binary mixture Y and Z or ternary mixture X, Y and Z using their derivative spectra at zero contribution of X while the interference of the third one was eliminated by the difference between two point's shows equal amplitudes on the mixture spectra [29][30][31][32] By subtracting the amplitudes at these two points in Eq. 21and (22), the amplitude representing Z would be cancelled along with any other instrumental error or any interference from the sample matrix. This could be summarized as the following:…”

Section: Differential Dual Wavelength (D 1 Dwl)mentioning

confidence: 99%

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Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Gummadi

Ganapaty

Almas

2018

Int J Pharm Pharm Sci

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The spectrophotometric multi-component analysis involves spectrum recording and mathematical equations. However, spectral interference poses a major limitation when mixture samples are encountered. To overcome this derivative spectrophotometry (DS) has been introduced for the resolution of overlapping peaks. In this review modified methods like derivative quotient spectra, double divisor ratio spectra derivative method, double divisor means centering of ratio spectra method, derivative subtraction coupled with the constant multiplication method (DS-CM), amplitude subtraction (AS), modified amplitude subtraction (MAS), amplitude factor method (P-Factor), amplitude modulation method (AM), amplitude summation method (A-Sum), simultaneous derivative ratio spectrophotometry (S1DD), derivative compensation ratio via regression equation, differential dual wavelength (D1 DWL), differential derivative ratio (D1DR), successive derivative subtraction method (SDS) and derivative transformation (DT) of derivative spectrophotometry theories and applications are reviewed. These methods were applied to solve different complex pharmaceuticals mixtures. These developed methods were simple and cost-effective.

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Section: Applicationsmentioning

confidence: 86%

Section: Differential Dual Wavelength (D 1 Dwl)mentioning

confidence: 99%

Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Gummadi

Ganapaty

Almas

2018

Int J Pharm Pharm Sci

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“…The method commences by dividing total spectrum of mixture by Y normalized spectra (a Y ) and recording the mixture (P m ) amplitude at a selected wavelength (λ P ). The amplitude difference a step in constant center method [ 39 , 40 ] will be applied to calculate X postulated amplitude (Px) in the binary mixture at (λ P ) by construct a regression equation representing difference between recorded amplitude of the ratio spectra of different concentration of component X using normalized Y as a divisor at two selected wavelengths (λ P , λ) versus amplitude value at λ P…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Induced mathematical filtration as an innovative strategy for discrimination and estimation of glycemic control drugs in fixed dose combination

Lotfy

Mohamed

2020

Heliyon

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An innovative strategy was developed for the estimation of a fixed dose combination containing Alogliptin (ALO) and pioglitazone (PIO) using induced concept for resolving the overlapped spectra, lacking isoabsorptive point. This strategy is based on coupling factors as numerical values or ratios as spectrum form with the recorded signals leading to induced mathematical filtration of the drug of interest and complete elimination of the interfering one in the combination without prior physical separation. The calculated factors were factor of equality in induced dual wavelength (IDW) or absorptivity factor in induced concentration subtraction method (ICS) while absorptivity ratio spectrum for induced amplitude modulation method (IAM). The calibration curves displayed linearity within 1.0–16.0 μg/mL for ALO and 2.0–22.0 μg/mL for PIO with good correlation coefficients. The induced methods specificity was also assured through the assaying different synthetic mixtures prepared to contain the two drugs in ratios approaching the ratio actually found in the marketed dosage form. The methods were applicable and suitable for estimating ALO and PIO in both bulk form and their fixed dose combination. Induced methods have been extensively validated in accordance with ICH guidelines and results demonstrated the accuracy and reproducibility in comparison to the reported method.

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“…Besides being applicable to the majority of binary and tertiary mixtures, the only requirement of this method is the selection of a wavelength, at which the absorbance of a compound cancels that for the other compounds 31 .…”

Section: Fig 2: Scanning Spectra Of Caffeine (Red) Catechin (Blue)mentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:A method using derivative UV spectrophotometry was developed and validated for the determination of methylxanthines and tannins in guarana bulk, using caffeine and catechin as markers. The spectra were obtained using first order derivatization, Δλ=20.000, and scale factor of 10. The quantification of actives was performed using wavelengths of 244 and 277 nm for catechin and caffeine, respectively. The parameters of specificity, linearity, precision, accuracy, robustness, limits of detection (LOD) and quantification (LOQ) were established to validate the method. The method was shown to be specific for quantification of methylxanthines and tannins, and linear over the concentration range 5-35 µg mL -1 , with a correlation coefficient of r=1(caffeine) and r=0.9993 (catechin). The results indicated good intra-day and inter-day precision with RSDs less than 2%. The method was accurate, exhibiting recoveries between 98 and 102%. The LODs were 0.184 µg mL -1 (caffeine) and 0.368 µg mL -1 (catechin), and the LOQs were 0.552 µg mL -1 (caffeine) and 1.104 µg mL -1 (catechin). Methylxanthines and tannins were quantified, and contents of 10 µg mL -1 and 20 µg mL -1 , respectively, were observed.

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Validated spectrophotometric methods for simultaneous determination of Omeprazole, Tinidazole and Doxycycline in their ternary mixture

Cited by 34 publications

References 19 publications

Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Derivative Uv Spectroscopic Approaches in Multicomponent Analysis–a Review

Induced mathematical filtration as an innovative strategy for discrimination and estimation of glycemic control drugs in fixed dose combination

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