Validated GC–MS analysis for the determination of residual fentanyl in applied Durogesic® reservoir and Durogesic® D-Trans® matrix transdermal fentanyl patches

Nimmen, Nadine F.J Van; Veulemans, Hendrik

doi:10.1016/j.jchromb.2006.09.002

Cited by 22 publications

(32 citation statements)

References 12 publications

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“…A few methods can determine residual fentanyl in applied Durotep ® MT patches. 11,12) Marier et al extracted residual fentanyl using 2-propanol. 12) Van Nimmen and Veulemans extracted fentanyl in shredded matrix patches using isotonic saline.…”

Section: Discussionmentioning

confidence: 99%

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Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application

Naito

Takashina

Yagi

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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A few complicated and time-consuming methods are available for the determination of residual fentanyl in Durotep ® MT transdermal patches, however, their application to clinical settings is limited. The aim of this study was to develop a simple and rapid HPLC-UV method using an ultrafine particle octadecylsilane (ODS) for the determination of residual fentanyl in applied Durotep ® MT transdermal matrix patches. Patch extraction involved sonicating a shredded Durotep ® MT patch in acetonitrile for 15 min. Fentanyl separation was completed within 2 min using a 2.3-μm particle ODS column (50 4.6 mm i.d.) at a flow rate of 1.5 mL/ min. No peaks interfering with fentanyl (1.27 min) and papaverine (0.89 min) as an internal standard were observed. The calibration curve for fentanyl was linear over the range of 0.015-9.0 mg as a Durotep ® MT patch. The intra-and inter-assay precisions and accuracies of each patch were within 5.3% and 103.9-110.5% and within 8.2% and 97.1-104.3%, respectively. The validated method was applied to determine residual fentanyl in Durotep ® MT patches used in 35 cancer patients. Although the plasma fentanyl concentration was significantly correlated with its measured absorption rate, the measured absorption rate normalized fentanyl concentration showed a large inter-individual variation. The validated simple and rapid HPLC-UV method established in the present study is helpful for evaluating the absorption rate of fentanyl in patients receiving Durotep ® MT patches.

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Section: Discussionmentioning

confidence: 99%

“…A few methods are available for the determination of residual fentanyl in transdermal matrix patches. 11,12) However, their application is limited in clinical settings. The earlier methods are time-consuming and involve complicated extraction procedures.…”

mentioning

confidence: 99%

Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application

Naito

Takashina

Yagi

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Papaverine, which is easy to obtain and rarely coadministered with fentanyl, was used an internal standard in our method. Several groups have measured residual fentanyl in applied Reservoir-TTS (6,(11)(12)(13) (13). Even though special instruments were used, the method is complex and time-consuming.…”

Section: Discussionmentioning

confidence: 99%

“…Some analytical methods are available for fentanyl in human plasma and in applied Reservoir-TTS (6,(11)(12)(13)(14)(15)(16). However, their use in clinical applications is limited.…”

Section: Introductionmentioning

confidence: 99%

Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure

Takashina

Naito

Mino

et al. 2009

Journal of Clinical Pharmacy and Therapeutics

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“…Highly sensitive methods of analysis for fentanyl have been established with gas chromatography (GC) and high-performance liquid chromatography (HPLC), especially in human plasma, hair or urine [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Nevertheless, very few methods of the degradation of fentanyl are reported in literatures.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Degradation of Fentanyl in Aqueous Solutions of Peroxides and Hypochlorites

Qi¹,

Cheng²,

Zuo³

et al. 2011

DSJ

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Fentanyl widely used in clinics as practices is potentially utilised as an incapacitant in countering terrorism and its analogues would be used as an addictive drug, so the degradation of these compounds need to be investigated for protecting environment and human health. In this work, the degradation of fentanyl was examined in a series of oxidant aqueous solutions. Meanwhile, the degradation pathways of fentanyl in the oxidant solution were discussed according to all products identified by GC/MS and LC/MS.

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Validated GC–MS analysis for the determination of residual fentanyl in applied Durogesic® reservoir and Durogesic® D-Trans® matrix transdermal fentanyl patches

Cited by 22 publications

References 12 publications

Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application

Simple and Rapid HPLC-UV Method Using an Ultrafine Particle Octadecylsilane for Determination of Residual Fentanyl in Applied Durotep MT Transdermal Matrix Patches and Its Clinical Application

Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure

Oxidative Degradation of Fentanyl in Aqueous Solutions of Peroxides and Hypochlorites

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