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A simple, selective and sensitive spectrophotometric method is described for the determination of mebendazole (MBD) in bulk drug and dosage forms. The method is based on the reaction of MBD with hypochlorite in the presence of sodium bicarbonate to form the chloro derivative of MBD, followed by the destruction of the excess hypochlorite by nitrite ion. The color was formed by the oxidation of iodide with the chloro derivative of MBD to iodine in the presence of starch and forming the blue colored product, which was measured at 570 nm. The optimum conditions that affect the reaction were ascertained and, under these conditions, a linear relationship was obtained in the concentration range of 1.25-25.0·g/ml MBD. The calculated molar absorptivity and Sandell sensitivity values are 9.56·10 3 l·mol -1 · cm -1 and 0.031 μg/cm 2 , respectively. The limits of detection and quantifi cation are 0.11 and 0.33 μg/ml, respectively. The proposed method was applied successfully to the determination of MBD in bulk drug and dosage forms, and no interference was observed from excipients present in the dosage forms. The reliability of the proposed method was further checked by parallel determination by the reference method and also by recovery studies.Introduction. Mebendazole (MBD), chemically known as methyl-5-benzoyl-2-benzimidazole carbamate, is an anthelmintic and antiinfestive used against hookworm, pinworm, roundworm, tapeworm, threadworm, and mixed infestations. It is available in tablet and suspension form. Depending on the type of worm to be treated, the dosage varies in adults and children [1]. MBD in bulk drug and tablet dosage form are both included in the USP 23 monographs [2], while the oral suspension is listed in the second supplement [3] of USP 23. The drug is also offi cial in Indian pharmacopoeia [4] and European pharmacopoeia [5], and the latter describes a potentiometric titration of 250 mg of MBD in formic acid-acetic acid and methyl ethyl ketone mixture with acetic HClO 4 . Different analytical methods are found in the literature for the assay of MBD in pharmaceuticals and include titrimetry [6-9], UV-spectrophotometry [9-12], phosphorimetry [13], proton nuclear magnetic resonance spectrometry [14], fl uorimetry [15,16], thermogravimetry [17,18], membrane-sensor based potentiometry [19], DC polarography [20], differential pulse polarography [21,22], high-performance liquid chromatography [23][24][25], and high-performance thin layer chromatography [26,27]. Most of these methods are complicated and need sophisticated instruments.The literature survey reveals several visible spectrophotometric methods. When MBD was hydrolyzed with KOH, a yellow colored substance (2-amino-5-benzoylbenzimidazole) was formed, which was measured at 420 nm [28]. MBD on treatment with hydroxylamine, dicyclohexylcarbodiimide, and FeCl 3 produced a red colored product measurable at 520 nm that served as a basis for an assay [29]. Kar [30] has described a method based on a 2:1 complex formed by MBD with potassium bismuth(III) iodide....
A simple, selective and sensitive spectrophotometric method is described for the determination of mebendazole (MBD) in bulk drug and dosage forms. The method is based on the reaction of MBD with hypochlorite in the presence of sodium bicarbonate to form the chloro derivative of MBD, followed by the destruction of the excess hypochlorite by nitrite ion. The color was formed by the oxidation of iodide with the chloro derivative of MBD to iodine in the presence of starch and forming the blue colored product, which was measured at 570 nm. The optimum conditions that affect the reaction were ascertained and, under these conditions, a linear relationship was obtained in the concentration range of 1.25-25.0·g/ml MBD. The calculated molar absorptivity and Sandell sensitivity values are 9.56·10 3 l·mol -1 · cm -1 and 0.031 μg/cm 2 , respectively. The limits of detection and quantifi cation are 0.11 and 0.33 μg/ml, respectively. The proposed method was applied successfully to the determination of MBD in bulk drug and dosage forms, and no interference was observed from excipients present in the dosage forms. The reliability of the proposed method was further checked by parallel determination by the reference method and also by recovery studies.Introduction. Mebendazole (MBD), chemically known as methyl-5-benzoyl-2-benzimidazole carbamate, is an anthelmintic and antiinfestive used against hookworm, pinworm, roundworm, tapeworm, threadworm, and mixed infestations. It is available in tablet and suspension form. Depending on the type of worm to be treated, the dosage varies in adults and children [1]. MBD in bulk drug and tablet dosage form are both included in the USP 23 monographs [2], while the oral suspension is listed in the second supplement [3] of USP 23. The drug is also offi cial in Indian pharmacopoeia [4] and European pharmacopoeia [5], and the latter describes a potentiometric titration of 250 mg of MBD in formic acid-acetic acid and methyl ethyl ketone mixture with acetic HClO 4 . Different analytical methods are found in the literature for the assay of MBD in pharmaceuticals and include titrimetry [6-9], UV-spectrophotometry [9-12], phosphorimetry [13], proton nuclear magnetic resonance spectrometry [14], fl uorimetry [15,16], thermogravimetry [17,18], membrane-sensor based potentiometry [19], DC polarography [20], differential pulse polarography [21,22], high-performance liquid chromatography [23][24][25], and high-performance thin layer chromatography [26,27]. Most of these methods are complicated and need sophisticated instruments.The literature survey reveals several visible spectrophotometric methods. When MBD was hydrolyzed with KOH, a yellow colored substance (2-amino-5-benzoylbenzimidazole) was formed, which was measured at 420 nm [28]. MBD on treatment with hydroxylamine, dicyclohexylcarbodiimide, and FeCl 3 produced a red colored product measurable at 520 nm that served as a basis for an assay [29]. Kar [30] has described a method based on a 2:1 complex formed by MBD with potassium bismuth(III) iodide....
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