Valeriana jatamansi partially reverses liver cirrhosis and tissue
hyperproliferative response in rat

Prasad, Ram; Naime, Mohammad; Routray, Indusmita; Mahmood, Amena; Khan, Farah; Ali, Shakir

doi:10.1358/mf.2010.32.10.1522224

Cited by 14 publications

(11 citation statements)

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“…Hence, we have enough time to make treatment on cirrhotic rats. In the literature, withdrawal of thioacetamide prior to the study was also acceptable as in Prasad study on cirrhotic rats (Prasad et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Pour

Mirazi

Alaei

et al. 2017

Can. J. Physiol. Pharmacol.

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Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.

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Section: Discussionmentioning

confidence: 99%

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Pour

Mirazi

Alaei

et al. 2017

Can. J. Physiol. Pharmacol.

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“…It is the end stage of liver fibrosis, which ultimately caused shrinkage of the liver, portal hypertension, and liver failure (Torok, ; Le Bousse‐Kerdiles, Martyre, & Samson, ). Prasad et al () provide evidences indicating the effect of the dried rhizome extract of V. jatamansi in an animal model of liver cirrhosis and on cell proliferation. Oral administration of extracts of this herb in the thioacetamide induced liver cirrhosis partially reverse the elevated levels of alkaline phosphatase, γ‐glutamyl transferase, and other biochemical markers of hepatic injury as well as the drug‐metabolizing enzymes.…”

Section: Medicinal Uses and Pharmacology Propertiesmentioning

confidence: 99%

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

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“…Hypericum also has reports of liver damage in rat fetuses whose mothers were exposed to hypericin 11 . Despite reports of hepatic disorders related to the use of hypericum, kava and valerian in therapeutic doses of 900 mg/Kg, 300 mg/Kg and 150 mg/Kg respectively [29][30] , the obtained results showed that the use of combined smaller doses (1/3 of the therapeutic doses) are not detrimental considering the biochemical parameters.…”

Section: Discussionmentioning

confidence: 61%

“…Liver damage may be hepatocellular, causing increased serum of the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes, or cholestatic, leading to increased bilirubin, alkaline phosphatase (ALP) and gamma-GT 29 . Studies have shown that chronic use of valerian causes hepatic toxicity in addition to side effects such as dyspepsia, allergic skin reactions, headache, and agitation 30 . Kava may exacerbate the status of patients with liver failure and hepatitis in those with a history of recurrent liver disease.…”

Section: Discussionmentioning

confidence: 99%

Analgesic effect of Hypericum perforatum, Valeriana officinalis and Piper methysticum for orofacial pain

Nowacki¹,

Worfel²,

Martins³

et al. 2015

Braz. J. Oral Sci.

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Aim: To evaluate in vivo the association of hypericum (Hypericum perforatum), valerian (Valeriana officinalis) and kava (Piper methysticum) with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts. Methods: Orofacial pain was induced in mice with the administration of 2.5% formalin in the upper lip. After 60 min, the animals were treated with saline, carbamazepine and hydroalcoholic plant extracts. The nociceptive intensity was determined by the timing at which the animal remained rubbing the injected area. To assess the hepatotoxic effect, mice were chronically treated for 25 days with saline, carbamazepine and hydroalcoholic extract. The animals were euthanized and the liver weighed, followed by a differential count of leukocytes and measurement of alanine transaminase and alkaline phosphatase. Results: The evaluation of analgesic activity in phase 1 reduced the time of rubbing compared to the control by 86% (0.05 mL/10 g) and 76% (0.10 mL/10 g). In phase 2, the extracts reduced rubbing time by 94% and 85%, respectively. In the evaluation of alkaline phosphatase, the groups treated with extracts at doses of 0.05 mL/10 g and 0.1 mL/10 g increased by 16.1% and 9.5% compared to the control group and a reduction of 8.5% and 9.1% in the evaluation of alanine transaminase respectively. It was demonstrated that in the differential counts showed an increase in eosinophils in the treated group with 0.05 mL/10 g. Conclusions: The use of hydroalcoholic extract of the associated plants reduced the orofacial formalin-induced pain with better results than carbamazepine, at both the neural conductor level of pain (phase 1) and in inflammatory or later pain (phase 2) without presenting hepatotoxicity. The observed eosinophilia is suggestive of a phenomenon called hormesis.

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Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat

Cited by 14 publications

References 0 publications

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Analgesic effect of Hypericum perforatum, Valeriana officinalis and Piper methysticum for orofacial pain

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