Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial

Morin, Charles M.; Koetter, Uwe; Bastien, Célyne; Ware, J. Catesby; Wooten, Virgil

doi:10.1093/sleep/28.11.1465

Cited by 162 publications

(108 citation statements)

References 36 publications

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“…We identified two RCTs that compared doxepin with placebo in the general adult population 131,132 (Table 20). Hajak et al 131 randomized 47 participants to doxepin 25 mg (increasing to 50 mg of doxepin as needed) or placebo.…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…Hajak et al 131 randomized 47 participants to doxepin 25 mg (increasing to 50 mg of doxepin as needed) or placebo. Krystal et al 132 randomized 229 participants to either doxepin 3 mg, doxepin 6 mg, or placebo.…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…Only Krystal et al 2011 132 reported ethnicity: in that trial, 48 percent of participants were white. Hajak et al 131 was conducted in Germany and Krystal et al 132 was conducted in the United States. Both RCTs reported industry sponsorship.…”

Section: Overview Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive Behavioral Therapy in the Treatment of Insomnia

Haynes¹,

Talbert²,

Fox³

et al. 2018

Southern Medical Journal

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Section: Overview Of Studiesmentioning

confidence: 99%

Section: Overview Of Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Behavioral Therapy in the Treatment of Insomnia

Haynes¹,

Talbert²,

Fox³

et al. 2018

Southern Medical Journal

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“…Claims for sleep improvement have been advanced for a variety of products and nutrient supplements for which there is evidence of mild efficacy [72]. Some literature also exists to support soporific claims for other nutritional supplements.…”

Section: Vitamins and Minerals Affecting On Sleepmentioning

confidence: 99%

Nutritional Modulators of Sleep Disorders

Sarrafi-Zadeh¹

2012

TONUTRAJ

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Abstract:Background: Clinical evidence indicates that insufficient sleep and poor sleep quality appear to be common consequences of shift work. These rhythms appear to have independent influence on the function of the endocrine system, circadian brain function and gastrointestinal tract. Insufficient sleep and its poor quality due to shift work interfere with beta cells, leptin and ghrelin functioning, resulting in factors for the development and exacerbation of insulin resistance. Human studies found that insufficient sleep alters the levels of leptin and ghrelin, two hormones involved in the regulation of appetite and body fat. Leptin, released by fat cells, signals the brain to feel satiety. Ghrelin, produced in the stomach, signals hunger. Investigations reported that temporarily sleep-deprived individuals experienced hormonal changes along with greater cravings for sweet and fatty foods. A further reason for their cravings is related to the stress hormone cortisol, which can rise with sleep deprivation and contribute to hunger. In addition to altered hormone levels, people who stay awake longer have more opportunity to eat, and late-night eating often includes high-caloric foods. Weight gain is only one of the many side effects of insufficient sleep, but it can lead to long-term health problems, including diabetes. Although more sleep will not automatically result in weight loss, sufficient sleep and a regular sleep schedule are critical in controlling appetite and promoting a healthy eating pattern. Research on sleep and appetite reveals a consistent link between a lower amount of sleep and a higher body mass index (BMI), a ratio of weight-to-height that indicates overweight. Studies showed those who slept less than eight hours a night were more likely to be overweight. Methods: Internet search and discussion with colleagues.Results: Recent research indicates that disruption of sleep can influence food intake and food and nutrients can influence sleep. There is evidence that high protein and carbohydrates meals can influence moods, attention and concentration among normal adult subjects with respect to age, gender and meal time. Women reported greater sleepiness after two hours of carbohydrate meal as opposed to a protein meal. On the other hand men reported greater calmness after a carbohydrate as opposed to a protein meal. Age of subjects may also influence the response to meals. After a carbohydrate or protein rich breakfast, persons older than 40 years felt more tense and less calm with a protein-rich than carbohydraterich meal. In general older subjects preferred carbohydrate than protein meals. Carbohydrate meals are also reported to impair objective performance; carbohydrate rich foods either in breakfast or lunch have exhibited negative influence on neural response such as impaired objective performance and poor sustained attention. A meal consumed close to bedtime is associated with sleep disturbances. Further, solid foods as well as large meals may cause more sleepiness than liquid foods. Studies...

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“…One such study compared the efficacy of a valerian-hops combination to that of diphenhydramine in insomnia over 6 weeks. They revealed modest improvement in sleep outcome measurements in both treatment arms 14 . However, no previous studies have compared the efficacy of single doses of valerian-hops to sedating antihistamine in terms of subjective sleep measures.…”

Section: Introductionmentioning

confidence: 98%

Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial

Gammoh

Al-Smadi

Mukattash

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Many sedatives and anxiolytics are used in single dose or chronically to aid sleep. Clinically important sedatives include valerian-hops and antihistamines as they are used over the counter and are highly accessible and safe agents. Objectives: To evaluate and compare a single dose of chlorpheniramine versus valerian-hops combination in modulating subjective sleep measures in insomniac war refugees. Methods: Insomnia among refugees was screened using the Insomnia Severity Index (ISI). Insomniac subjects were randomized to received a single dose valerian-hops (320/80 mg) (n = 65), or chlorpheneramine (4 mg) (n = 50) or placebo (n = 76) two hours prior sleeping. Participants were instructed to complete Leeds Sleep Evaluation Questionnaire (LSEQ), visual analogue scales of anxiety and sedation. Also sleep latency, total hours slept and self-rated improvement were obtained. Results: Almost 75% of screened refugees had insomnia. Chlorpheneramine reduced sleep latency and anxiety significantly, however it resulted in poor sleep quality. Valerian-hops group showed marked anxiolysis one hour after dosing, a sleep quality similar to placebo and better than chlorpheneramine, and better alertness compared to placebo. Participants satisfaction was higher with chlorpheneramine and there was no difference in the total hours slept. Discussion: Valerian-hops combination may provide better sleep quality than antihistamines.

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Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial

Cited by 162 publications

References 36 publications

Cognitive Behavioral Therapy in the Treatment of Insomnia

Cognitive Behavioral Therapy in the Treatment of Insomnia

Nutritional Modulators of Sleep Disorders

Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial

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