Valence-switchable and biocatalytic vanadium-based MXene nanoplatform with photothermal-enhanced dual enzyme-like activities for anti-infective therapy

Sun, Xiaoshuai; He, Xiaojun; Zhu, Yue; Obeng, Enoch; Zeng, Bairui; Deng, Hui; Shen, Jianliang; Hu, Rongdang

doi:10.1016/j.cej.2022.138985

Cited by 27 publications

(18 citation statements)

References 57 publications

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“…According to five repeated “heating/cooling” cyclic measurements, no decay in the temperature change is observed (Figure 2d), suggesting good photothermal stability. Based on previous studies, [ 33 ] the photothermal conversion efficiencies (PCE) of M, MPM, and MPMP nanozymes are calculated as 12.35%, 43.07%, and 36.40%, respectively (Figure 2e). When MoS 2 nanosheets are absent, the corresponding PDA (P), PDA‐Mg (PM), and PDA‐Mg@PSBMA (PMP) nanoparticles exhibited better photothermal behaviors and higher PCE (55.08% for P, 48.01% for PM and 47.50% for PMP) (Figure S16, Supporting Information), indicating that polydopamine contributes more to photothermal conversion than MoS 2 nanosheets.…”

Section: Resultsmentioning

confidence: 99%

Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

Sun

et al. 2023

Advanced Materials

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Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS2) with Mg2+–doped polydopamine and coating with polysulfobetaines, we constructed a dual–bionic photothermal nanozyme (MPMP) to mimic antioxidases/hyaluronan synthase for OA therapy. Photothermally enhanced lubrication lowered the coefficient of friction (0.028) in the early stage of OA treatment. The antioxidases–mimicking properties of MPMP nanozyme contributed to eliminating ROS/RNS (over 90% of scavenging ratio for H2O2/·OH/O·–2/DPPH/ABTS+) and supplying O2. With NIR irradiation, MPMP nanozyme triggered thermogenesis (upregulating HSP70 expression) and Mg2+ release, which promoted the chondrogenesis in inflammatory conditions by deactivating of NF–κB/IL–17 signaling pathways and enhancing MAPK signaling pathway. Benefiting from HSP70 and Mg2+, MPMP–NIR showed HAS–mimicking activity to increase the intracellular (2.00–fold) and extracellular (3.12–fold) HA production. Therefore, MPMP–NIR demonstrated superior spatiotemporally therapeutic effect on OA in mice model, in terms of osteophytes (83.41% reduction), OARSI scores (88.57% reduction) and ACAN expression (2.70–fold increment). Hence, insights into dual–bionic nanozymes can be a promising strategy for OA therapy or other inflammation–related diseases.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

Sun

et al. 2023

Advanced Materials

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“…MXene-based nanozymes with POD-like activities have been used for antibacterial applications. [105][106][107][108][109] For example, Li et al 105 Yuan et al 106 designed and constructed a CeO 2 /Nb 2 C nanozyme with dual functions of POD-like activity and excellent near-infrared (NIR) photothermal properties. Under 808 nm laser irradiation, the CeO 2 /Nb 2 C produced a photothermal antibacterial effect and also displayed a synergistic enzyme catalytic property, killing bacteria with a sterilization ratio greater than 80%.…”

Section: Antibacterial Agentsmentioning

confidence: 99%

“…In another work, 107 vanadium nitride MXenes (e.g., V 2 N) were prepared by a modified chemical exfoliation approach. With the valence-switchable state and large specific surface area, the V 2 N-based nanomaterials possessed intrinsic OD-like and POD-like activities.…”

Section: Antibacterial Agentsmentioning

confidence: 99%

“…MXene-based nanozymes with POD-like activities have been used for antibacterial applications. 105–109 For example, Li et al 105 prepared Ti 3 C 2 -based nanocomposites by hybridizing Pt single-atom (Pt-/Ti 3 C 2 ). The single-atom Pt exhibited good POD-like activity to catalyze H 2 O 2 and generate hydroxyl radicals, which could kill bacteria and remove biofilms.…”

Section: Biomedical Applications Of Mxene-based Nanozymesmentioning

confidence: 99%

“…In another work, 107 vanadium nitride MXenes ( e.g. , V 2 N) were prepared by a modified chemical exfoliation approach.…”

Section: Biomedical Applications Of Mxene-based Nanozymesmentioning

confidence: 99%

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MXene-based nanomaterials with enzyme-like properties for biomedical applications

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Sheng

Ding

et al. 2023

Advanced Materials

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Nanomaterials with more than one enzyme‐like activity are termed multi‐enzymic nanozymes, which have received increasing attention in recent years and hold huge potential to be applied in diverse fields, especially for biosensing and therapeutics. Compared to single enzyme‐like nanozymes, multi‐enzymic nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, and environmentally‐responsive selectivity. Nevertheless, along with these merits, the catalytic mechanism and rational design of multi‐enzymic nanozymes are more complicated and elusive as compared to single‐enzymic nanozymes. In this review, we systematically discussed the multi‐enzymic nanozymes classification scheme based on the numbers/types of activities, the internal and external factors regulating the multi‐enzymatic activities, the rational design based on chemical, biomimetic, and computer‐aided strategies, and recent progress in applications attributed to the advantages of multi‐catalytic activities. Finally, current challenges and future perspectives regarding the development and application of multi‐enzymatic nanozymes are suggested. This review aims to deepen the understanding and inspire the research in multi‐enzymic nanozymes to a greater extent.This article is protected by copyright. All rights reserved

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Valence-switchable and biocatalytic vanadium-based MXene nanoplatform with photothermal-enhanced dual enzyme-like activities for anti-infective therapy

Cited by 27 publications

References 57 publications

Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis

MXene-based nanomaterials with enzyme-like properties for biomedical applications

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

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