Valence and agency influence striatal response to feedback in patients with major depressive disorder

Späti, Jakub; Chumbley, Justin R.; Doerig, Nadja; Brakowski, Janis; Holtforth, Martin Grosse; Seifritz, Erich; Spinelli, Simona

doi:10.1503/jpn.140225

Cited by 9 publications

(9 citation statements)

References 61 publications

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“…However, the use of a summary score as our primary measure of agency may limit this bias since it avoids scaling effects and assesses judgments relative to the patient’s own references. In addition, no effect on self-attribution (agency) has been shown in patients with major depressive episodes [ 39 ]. Similarly, in patients with functional movement disorders, a recent neuroimaging study demonstrated decreased functional connectivity in neuronal networks implicated in the sense of agency but no effect of depressive state on functional connectivity in this network [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

et al. 2016

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BackgroundAbnormalities in the cognitive processing of movement have been demonstrated in patients with dystonia. The sense of agency, which is the experience of initiating and controlling one’s own actions, has never before been studied in these patients.ObjectivesWe investigated whether the sense of agency is altered in patients with cervical dystonia.MethodsWe used an explicit metacognitive agency task in which participants had to catch targets with a cursor by moving a computer’s mouse. The task included several conditions in which the control over the cursor could be disrupted by adding a spatial or a temporal discrepancy between the mouse and the cursor’s movements. Participants had to acknowledge these discrepancies and reflect them in metacognitive judgements of agency.ResultsTwenty cervical dystonia patients and 20 matched controls were included in the study. Despite performing equally well as the matched controls, cervical dystonia patients did not fully recognize alterations of agency when a temporal lag was added between their movement and the visual feedback. Moreover, they relied predominantly on their perceived performance to provide judgements of agency and less on their objective degree of controls. There was no correlation between agency scores and clinical severity of dystonia measured by the Toronto Western Spasmodic Torticollis Rating Scale.ConclusionWe demonstrated an abnormal processing of agency in cervical dystonia patients, even for motor actions not affected by dystonia. The exact contribution of abnormal agency to dystonia pathophysiology remains to be clarified.

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Section: Discussionmentioning

confidence: 99%

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

et al. 2016

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“…In depression and anxiety disorders, the outcome valence of the social response might be of greater importance compared to individuals with autism or schizophrenia. Depression, as well as social anxiety disorder, is known to be associated with a negative bias in emotional processing and a reduced sensitivity to positive feedback [142,143]. Since agency is dependent on outcome valence [4,5] which is also true for social reactions, it is likely that patients with depression and social anxiety disorder show a decreased experience of social agency compared to neurotypical individuals, particularly when receiving positive social feedback.…”

Section: Social Agency To Investigate Transdiagnostic Social Impairmementioning

confidence: 99%

The Interactive Self – A Review on Simulating Social Interactions to Understand the Mechanisms of Social Agency

Brandi

Kaifel

Bolis

et al. 2019

I-Com

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The sense of agency is a core element of self-experiences and is defined as the feeling of oneself being the ‘initiator’ of an action. It is thought to depend on an implicit coupling of action-outcome predictions and the sensory perception of the action. This concept is well-studied in the motor-domain, but less is known about agency during social interactions. It is clear that a sense of agency also occurs when we perform a social action (e. g. looking at someone’s eyes) and receiving feedback by another person (e. g. returning eye-contact). Here, we will refer to the experience of agency within a social interaction as the sense of social agency. The main aim of this article is to first, describe the concept of social agency and second review how virtual reality can help to simulate social interactions in order to systematically study self-experiences and social agency. Gaze-contingent eye-tracking paradigms represent a powerful tool in this endeavour, while we emphasise the importance of implementing ecologically valid, interactive stimuli. We furthermore propose a computational approach that can be useful to analyse such data based on the concept of predictive processing. Finally, we highlight the clinical relevance of this account and suggest how this approach can be helpful in providing a mechanistic description of social impairments across various psychiatric disorders. With this article, we attempt to review previous experimental work, suggest new methodological procedures and encourage future empirical research in the field.

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“…It has been previously shown that while valence and magnitude modulated BOLD signal in nucleus accumbens, probability affected signal coming from medial prefrontal cortex (mPFC), and ACC was proposed as a hub, integrating information about valence, probability and magnitude (Knutson et al, 2005). In other studies the difference in processing gains and losses or omission of gain was also localized in ventral striatum (Ferdinand and Opitz, 2014b;Satterthwaite et al, 2012;Späti et al, 2015;Zink et al, 2004). Involvement of mPFC in probability estimation is well described in literature (Alexander and Brown, 2012;Braver, 2005, 2007;Krawitz et al, 2011).…”

Section: Discussionmentioning

confidence: 92%

RL mechanisms of short-term plasticity of auditory cortex

Krugliakova

Gorin

Шестакова

et al. 2016

Preprint

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The decision-making process is exposed to modulatory factors, and, according to the expected value (EV) concept the two most influential factors are magnitude of prospective behavioural outcome and probability of receiving this outcome. The discrepancy between received and predicted outcomes is reflected by the reward prediction error (RPE), which is believed to play a crucial role in learning in dynamic environment. Feedback related negativity (FRN), a frontocentral negative component registered in EEG during feedback presentation, has been suggested as a neural signature of RPE. In modern neurobiological models of decision-making the primary sensory input is assumed to be constant over the time and independent of the evaluation of the option associated to it. In this study we investigated whether the electrophysiological changes in auditory cues perception is modulated by the strengths of reinforcement signal, represented in the EEG as FRN.We quantified the changes in sensory processing through a classical passive oddball paradigm before and after performance a neuroeconomic monetary incentive delay (MID) task. Outcome magnitude and probability were encoded in the physical characteristics of auditory incentive cues. We evaluated the association between individual biomarkers of reinforcement signal (FRN) and the degree of perceptual learning, reflected by changes in auditory ERP components (mismatch negativity and P3a).We observed a significant correlation of MMN and valence -dFRN, reflecting differential processing of gains and omission of gains. Changes in P3a were correlated to probability -dFRN, including information on salience of the outcome, in addition to its valence.MID task performance evokes plastic changes associated with more fine-grained discrimination of auditory anticipatory cues and enhanced involuntary attention switch towards these cues. Observed Feedback processing in MID task and consecutive changes in sensory perception of the anticipatory cues signatures of neuro-plasticity of the auditory cortex may play an important role in learning and decision-making processes through facilitation of perceptual discrimination of valuable external stimuli. Thus, the sensory processing of options and the evaluation of options are not independent as implicitly assumed by the modern neuroeconomics models of decision-making. Feedback processing in MID task and consecutive changes in sensory perception of the anticipatory cues 1.

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Valence and agency influence striatal response to feedback in patients with major depressive disorder

Cited by 9 publications

References 61 publications

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

The Interactive Self – A Review on Simulating Social Interactions to Understand the Mechanisms of Social Agency

RL mechanisms of short-term plasticity of auditory cortex

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