2002
DOI: 10.1097/00042728-200204000-00006
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Valacyclovir Prophylaxis for Herpes Simplex Virus Infection or Infection Recurrence Following Laser Skin Resurfacing

Abstract: background. The CO 2 laser for cutaneous resurfacing has been associated with the reactivation of herpes simplex virus (HSV), causing delayed reepithelialization and scarring. Antiviral agents appear to be effective in reducing reactivation, however, the optimal therapeutic regimen has yet to be clearly defined. objective. To assess the reactivation rates of HSV after CO 2 laser resurfacing in patients who received prophylactic valacyclovir for either 10 or 14 days. methods. One hundred twenty patients receive… Show more

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Cited by 17 publications
(32 citation statements)
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“…The use of aggressive techniques, including use of high energy densities, multiple passes, and overlapping spots or scans can increase the risk of hypertrophic scarring and infections (Cases 13 and 16). The management of infection risk has been controversial, and various regimens of prophylaxis against viral, bacterial, fungal infections, and post-operative wound care have been recommended [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Ideally, antimicrobial prophylaxis should be tailored to individual risks (Case 12) and the timely management can minimize adverse outcomes (Cases 12, 13, and 14).…”
Section: Discussionmentioning
confidence: 99%
“…The use of aggressive techniques, including use of high energy densities, multiple passes, and overlapping spots or scans can increase the risk of hypertrophic scarring and infections (Cases 13 and 16). The management of infection risk has been controversial, and various regimens of prophylaxis against viral, bacterial, fungal infections, and post-operative wound care have been recommended [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Ideally, antimicrobial prophylaxis should be tailored to individual risks (Case 12) and the timely management can minimize adverse outcomes (Cases 12, 13, and 14).…”
Section: Discussionmentioning
confidence: 99%
“…If there is a history of HSV infection, prophylactic treatment with valacyclovir a day before treatment is recommended. 15 Although rare now, gold-salt intake is a contraindication because it can cause cutaneous hyperpigmentation (chrysiasis). 16 Active use of isotretinoin is also a contraindication due to impaired tissue healing and skin fragility.…”
Section: Pretreatment Considerationsmentioning
confidence: 99%
“…HSV has been reported with laser resurfacing, and if present it can result in delayed healing, secondary bacterial infection, and severe scarring [55,58,59]. The mechanism of reactivation is thought to occur due to epidermal trauma of the laser procedure.…”
Section: Preventionmentioning
confidence: 99%