Valaciclovir for Epstein-Barr Virus Suppression in Moderate-to-Severe COPD

Linden, Dermot; Guo-Parke, Hong; McKelvey, Michael C; Einarsson, G; Lee, Andrew; Fairley, Derek; Brown, Vanessa; Lundy, Gavin; Campbell, Christina; Logan, Danielle; McFarland, Margaret; Singh, Dave; McAuley, Daniel F.; Taggart, Clifford C.; Kidney, Joseph C.

doi:10.1016/j.chest.2023.03.040

Cited by 3 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our patient there were initial concerns for hemophagocytic lymphohistiocytosis given the recognised role of EBV in precipitating similar reactions in other inborn errors of immunity. Valaciclovir is an inhibitor of EBV replication and has been suggested to be an adjunct therapy in the treatment of hemophagocytic lymphohistiocytosis and has been shown to inhibit viral shedding [ 16 – 18 ]. In our patient, a continuous reduction in quantitated levels of EBV without the addition of other immunomodulators was noted, with elimination of viraemia over 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Development of EBV Related Diffuse Large B-cell Lymphoma in Deficiency of Adenosine Deaminase 2 with Uncontrolled EBV Infection

Gardner,

Vaughan,

Avery

et al. 2024

J Clin Immunol

View full text Add to dashboard Cite

Deficiency of Adenosine Deaminase 2 (DADA2) patients presenting with primary immunodeficiency are at risk of uncontrolled EBV infection and secondary malignancies including EBV-related lymphoproliferative disorders (LPD). This paper describes the first case of EBV related diffuse large B-cell lymphoma in a patient with DADA2 and uncontrolled EBV infection. Consideration should be given to monitoring for EBV viraemia and to preventative EBV specific therapy in DADA2 and patients with at risk primary immunodeficiencies. A type I interferon (IFN) gene signature is associated with DADA2 though its association with immune dysregulation is unclear.

show abstract

Section: Discussionmentioning

confidence: 99%