Val66Met BDNF Gene Polymorphism Influences Human Motor Cortex Plasticity in Acute Stroke

Lazzaro, Vincenzo Di; Pellegrino, Giovanni; Pino, Giovanni Di; Corbetto, Marzia; Ranieri, Federico; Brunelli, Nicoletta; Paolucci, Matteo; Bucossi, Serena; Ventriglia, Maria C.; Brown, Peter; Capone, Fioravante

doi:10.1016/j.brs.2014.08.006

Cited by 66 publications

(63 citation statements)

References 34 publications

(47 reference statements)

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“…While interest has centred on genes known to contribute to neuroplasticity (27), there are a number of candidate biomarkers to consider as well as gene-gene interactions, and epigenetics.…”

Section: Theme 2: Recovery Biomarkersmentioning

confidence: 99%

Moving Rehabilitation Research Forward: Developing Consensus Statements for Rehabilitation and Recovery Research

Bernhardt

Borschmann

Boyd

et al. 2017

Neurorehabil Neural Repair

100

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Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardised terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology. We urgently need to better understand the biology of recovery and its time course in both animals and humans to translate evidence from basic science into clinical trials. A new international partnership of stroke recovery and rehabilitation experts has committed to advancing the research agenda. In May 2016 the first Stroke Recovery and Rehabilitation Roundtable will be held, with the aim of achieving an agreed approach to the development, conduct and reporting of research. A range of methods will be used to achieve consensus in four priority areas: Pre-clinical recovery research; Biomarkers of recovery; Intervention development, monitoring and reporting and; Measurement in clinical trials. We hope to foster a global network of researchers committed to advancing this exciting field. Recovery from stroke is challenging for many survivors. They deserve effective treatments underpinned by our evolving understanding of brain recovery and human behaviour.Working together we can develop game-changing interventions to improve recovery and quality of life in those living with stroke.

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“…While interest has centred on genes known to contribute to neuroplasticity (27), there are a number of candidate biomarkers to consider as well as gene-gene interactions, and epigenetics.…”

Section: Theme 2: Recovery Biomarkersmentioning

confidence: 99%

Moving Rehabilitation Research Forward: Developing Consensus Statements for Rehabilitation and Recovery Research

Bernhardt

Borschmann

Boyd

et al. 2017

Neurorehabil Neural Repair

100

View full text Add to dashboard Cite

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“…23 Individuals' genetic profiles may also influence recovery. [24][25][26] While interest has centred on genes known to contribute to neuroplasticity, 27 there are a number of candidate biomarkers to consider as well as gene-gene interactions and epigenetics.…”

Section: Theme 2: Recovery Biomarkersmentioning

confidence: 99%

Moving rehabilitation research forward: Developing consensus statements for rehabilitation and recovery research

Bernhardt

Borschmann

Boyd

et al. 2016

International Journal of Stroke

135

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Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology. We urgently need to better understand the biology of recovery and its time course in both animals and humans to translate evidence from basic science into clinical trials. A new international partnership of stroke recovery and rehabilitation experts has committed to advancing the research agenda. In May 2016, the first Stroke Recovery and Rehabilitation Roundtable will be held, with the aim of achieving an agreed approach to the development, conduct and reporting of research. A range of methods will be used to achieve consensus in four priority areas: preclinical recovery research; biomarkers of recovery; intervention development, monitoring and reporting; and measurement in clinical trials. We hope to foster a global network of researchers committed to advancing this exciting field. Recovery from stroke is challenging for many survivors. They deserve effective treatments underpinned by our evolving understanding of brain recovery and human behaviour. Working together, we can develop game-changing interventions to improve recovery and quality of life in those living with stroke.

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“…Cortical plastic changes after acute stroke may also be influenced by genetic factors. One study showed that repetitive transcranial magnetic stimulation inducing long term potentiation-like activity differed less between the affected and unaffected hemisphere in patients with the BDNF rs6265, Val66Met polymorphism than those without, and the authors proposed that this may be beneficial in less severe strokes but unfavorable in severe strokes, 30 suggesting that genetic variations may play alternative roles in different settings.…”

Section: Animal Models and Surrogate Markers For Studying Stroke Recomentioning

confidence: 99%

“…10 The BDNF single nucleotide variation (rs6265, Val66Met; Table 1) influences excitability and outcome. 30,31,33 High-frequency repetitive transcranial magnetic stimulation over the primary motor cortex of the affected hemisphere induces positive effects on motor function, and subjects with the Val/Val genotype have better improvement. 29 Long-term mortality after stroke and stroke recurrence genetics has been studied in several studies (Table 1).…”

Section: Neurological/physical Deficitmentioning

confidence: 99%

Stroke Recovery Genetics

Lindgren

Maguire

2016

Stroke

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Val66Met BDNF Gene Polymorphism Influences Human Motor Cortex Plasticity in Acute Stroke

Abstract: Background-BDNF gene polymorphism impacts human motor cortex function and plasticity.

Cited by 66 publications

References 34 publications

Moving Rehabilitation Research Forward: Developing Consensus Statements for Rehabilitation and Recovery Research

Moving Rehabilitation Research Forward: Developing Consensus Statements for Rehabilitation and Recovery Research

Moving rehabilitation research forward: Developing consensus statements for rehabilitation and recovery research

Stroke Recovery Genetics

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