Vaisseaux humains reconstitués par génie tissulaire

Stoclet, Jean‐Claude; Laflamme, Karina; Auger, François A.; Germain, Lucie

doi:10.1051/medsci/2004206-7675

Cited by 5 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flow accumulator thus simulates the physiological compliance property (C parameter in WK models) associated with tissue proclivity to expand under a blood pressure increase. Many studies have reported the importance of an accurate reproduction of compliant effects in bioreactors, 1 , 2 especially in tissue engineering applications 3 – 6 where strong evidence of a significant relation between the dynamic frequency spectrum of the pulsating flow and tissue compliance has been observed.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling and experimental testing of three bioreactor configurations based on windkessel models

Ruel¹,

Lachance²

2010

Heart Int

View full text Add to dashboard Cite

This paper presents an experimental study of three bioreactor configurations. The bioreactor is intended to be used for the development of tissue-engineered heart valve substitutes. Therefore it must be able to reproduce physiological flow and pressure waveforms accurately. A detailed analysis of three bioreactor arrangements is presented using mathematical models based on the windkessel (WK) approach. First, a review of the many applications of this approach in medical studies enhances its fundamental nature and its usefulness. Then the models are developed with reference to the actual components of the bioreactor. This study emphasizes different conflicting issues arising in the design process of a bioreactor for biomedical purposes, where an optimization process is essential to reach a compromise satisfying all conditions. Two important aspects are the need for a simple system providing ease of use and long-term sterility, opposed to the need for an advanced (thus more complex) architecture capable of a more accurate reproduction of the physiological environment. Three classic WK architectures are analyzed, and experimental results enhance the advantages and limitations of each one.

show abstract

Section: Introductionmentioning

confidence: 99%

Mathematical modeling and experimental testing of three bioreactor configurations based on windkessel models

Ruel¹,

Lachance²

2010

Heart Int

View full text Add to dashboard Cite

show abstract

“…Reproduction of compliant effects is essential as it directly influences the compliance of the tissues cultured in the bioreactor. 10,23 The compliance of engineered valvular or arterial tissues constitutes one of the most significant mechanical properties to meet in order to assure replacement success. It is a well documented fact that numbers of post-surgical complications and vascular occlusions are attributed to compliance mismatch between substitute and original tissues.…”

Section: Introductionmentioning

confidence: 99%

A New Bioreactor for the Development of Tissue-Engineered Heart Valves

Ruel

Lachance

2009

Ann Biomed Eng

View full text Add to dashboard Cite

This paper reports the design, manufacturing, and characterization of a new bioreactor dedicated to the development of tissue-engineered heart valve substitutes. First, a comprehensive review of the state of the art in bioreactors is presented and a rigorous classification is put forward. The existing bioreactors found in literature are organized in three groups and discussed with respect to their quality of reproduction compared to the physiological environment. The bioreactor architecture is then decomposed into basic components which may be grouped together in different arrangements, and the well-known Windkessel approach is used to study the global behavior of the system. Then, the new design, which is based on a synthesis of the features of the most evolved systems as well as on new improvements, is explained in detail. Optimal fluid dynamics are obtained with the presented bioreactor through carefully designed components and an advanced computer-controlled actuator. This allows a very accurate reproduction of physiological parameters, namely the pulsating flow rate and pressure. Finally, experimental results of flow rate and pressure waveforms are presented, where an excellent correlation with physiological measurements can be observed.

show abstract