Vagus Nerve Stimulation and Prucalopride Have Anti-Inflammatory Properties and Improve Postoperative Ileus in Human

Stakenborg, Nathalie; Gomez‐Pinilla, Pedro J.; Aerts, Raymond; Appeltans, Iris; Beek, Kim Van; Wolthuis, Albert; D’Hoore, André; Bosmans, Goele; Labeeuw, Evelien; Verheijden, Simon; Matteoli, Gianluca; Boeckxstaens, Guy E.

doi:10.1016/s0016-5085(17)33146-3

Cited by 4 publications

(3 citation statements)

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“…In murine POI models, vagal nerve stimulation reduced the activation of MM with a subsequent reduction in infiltrating inflammatory cells and improved GIT [141,142]. A preclinical model using pigs has demonstrated that laparoscopic abdominal vagal nerve stimulation is safe and a potentially viable method [143], as well as a pilot study in humans [144] showing promise for its translation into human and even potentially equine medicine.…”

Section: Anti-inflammatoriesmentioning

confidence: 99%

“…This was termed the cholinergic anti-inflammatory pathway, as Ach is the parasympathetic neurotransmitter involved. A preclinical model using pigs has demonstrated that laparoscopic abdominal vagal nerve stimulation is safe and a potentially viable method [143], as well as a pilot study in humans [144] showing promise for its translation into human and even potentially equine medicine. In murine POI models, vagal nerve stimulation reduced [141,142].…”

Section: Anti-inflammatoriesmentioning

confidence: 99%

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An update on equine post‐operative ileus: Definitions, pathophysiology and management

Lisowski

Pirie

Blikslager

et al. 2018

Equine Veterinary Journal

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Post-operative ileus (POI) is a serious condition which any horse undergoing abdominal surgery is at risk of developing, leading to increased hospitalisation time and resulting costs. Advances in the understanding of the development of equine POI are mainly based on human and rodent literature, where manipulation-induced inflammation has been identified as a trigger, with activation of resident muscularis externa macrophages playing a crucial role in the pathophysiology. Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence.

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Section: Anti-inflammatoriesmentioning

confidence: 99%

Section: Anti-inflammatoriesmentioning

confidence: 99%

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Lisowski

Pirie

Blikslager

et al. 2018

Equine Veterinary Journal

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“…A recent trial by Gong and colleagues 16 showed that administration of prucalopride after elective colorectal surgery improved time to passage of flatus and stool. Recent studies have shown that prucalopride, when given before surgery and continued in the postoperative phase, reduces the inflammatory response associated with surgery 17 , and improves time to tolerance of diet 18 .…”

Section: Introductionmentioning

confidence: 99%

Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial

Milne

Liu

O’Grady

et al. 2022

British Journal of Surgery

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Background Delayed return to gut function and prolonged postoperative ileus (PPOI) delay recovery after colorectal surgery. Prucalopride is a selective serotonin-4-receptor agonist that may improve gut motility. Methods This was a multicentre, double-blind, parallel, placebo-controlled randomized trial of 2 mg prucalopride versus placebo in patients undergoing elective colorectal resection. Patients with inflammatory bowel disease and planned ileostomy formation were excluded, but colostomy formation was allowed. The study medication was given 2 h before surgery and daily for up to 6 days after operation. The aim was to determine whether prucalopride improved return of gut function and reduced the incidence of PPOI. The primary endpoint was time to passage of stool and tolerance of diet (GI-2). Participants were allocated in a 1 : 1 ratio, in blocks of 10. Randomization was computer-generated. All study personnel, medical staff, and patients were blinded. Results This study was completed between October 2017 and May 2020 at two tertiary hospitals in New Zealand. A total of 148 patients were randomized, 74 per arm. Demographic data were similar in the two groups. There was no difference in median time to GI-2 between prucalopride and placebo groups: 3.5 (i.q.r. 2–5) versus 4 (3–5) days respectively (P = 0.124). Prucalopride improved the median time to passage of stool (3 versus 4 days; P = 0.027) but not time to tolerance of diet (2 versus 2 days; P = 0.669) or median duration of hospital stay (4 versus 4 days; P = 0.929). In patients who underwent laparoscopic surgery (125, 84.5 per cent), prucalopride improved median time to GI-2: 3 (2–4) days versus 4 (3–5) days for placebo (P = 0.012). The rate of PPOI, complications, and adverse events was similar in the two groups. Conclusion Prucalopride did not improve time to overall recovery of gut function after elective colorectal surgery. Registration number: NCT02947269 (http://www.clinicaltrials.gov).

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Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Maheshwari

Sood

2022

Pediatric Neurogastroenterology

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Vagus Nerve Stimulation and Prucalopride Have Anti-Inflammatory Properties and Improve Postoperative Ileus in Human

Cited by 4 publications

References 0 publications

An update on equine post‐operative ileus: Definitions, pathophysiology and management

An update on equine post‐operative ileus: Definitions, pathophysiology and management

Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

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