Vaginal suppositories containingLactobacillus acidophilus: development and characterization

Abstract

Hollow-type suppositories showed to be promising delivery vehicles for vaginal delivery of probiotics.

Evaluation of the Live Biotherapeutic Product, Asymptomatic BacteriuriaEscherichia coli2‐12, in Healthy Dogs and Dogs with Clinical RecurrentUTI

“…Alternative approaches for prevention and treatment of recurrent UTI that have been investigated in human beings as well as animal UTI models include the use of cranberry extract, cranberry juice, probiotics, live biotherapeutic products (LPBs), vaccines, and various other alternative treatments . Live biotherapeutic products appear promising for treatment of recurrent UTI for several reasons.…”

Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

“… 101 The results suggest that hollow-type suppositories are promising for vaginal delivery when sustained release and high viability of probiotics are required. 101 Camilletti et al also developed vaginal ovules containing L. fermentum L23 and L. rhamnosus L60, demonstrating that these vaginal formulations maintained not only lactobacilli viability during storage at 4 °C for 180 days but also retained their antimicrobial and biofilm-producing ability. 102 Kale et al developed vaginal suppositories containing Bacillus coagulans .…”

“… 100 Rodrigues et al developed both solid body and hollow-type suppositories for the vaginal delivery of Lactobacillus acidophilus . 101 They used polyethylene glycol 400 and 4000 or Witepsol H12 as a hydrophilic and hydrophobic base, respectively, where L. acidophilus was incorporated in the molten mass before molding solid body suppositories or added as suspension into the cavity of hollow-type suppositories. 101 The results suggest that hollow-type suppositories are promising for vaginal delivery when sustained release and high viability of probiotics are required.…”

“… 101 They used polyethylene glycol 400 and 4000 or Witepsol H12 as a hydrophilic and hydrophobic base, respectively, where L. acidophilus was incorporated in the molten mass before molding solid body suppositories or added as suspension into the cavity of hollow-type suppositories. 101 The results suggest that hollow-type suppositories are promising for vaginal delivery when sustained release and high viability of probiotics are required. 101 Camilletti et al also developed vaginal ovules containing L. fermentum L23 and L. rhamnosus L60, demonstrating that these vaginal formulations maintained not only lactobacilli viability during storage at 4 °C for 180 days but also retained their antimicrobial and biofilm-producing ability.…”

Intravaginal Delivery Approaches for Contraception: An Overview with Emphasis on Gels

“…Hatem et al (26) have also developed a vaginal suppository containing combination of zinc acetate and N-9 to minimize the vaginal irritation rates caused by using N-9 alone. Moreover, vaginal suppositories containing lactobacillus were also developed which served to reduce the chances of relapse of urinary tract infections after antimicrobial treatment (27). Amphotericin B vaginal suppositories were also used by women for curing non-albicans Candida vaginitis (28).…”