Vaginal stenosis in women with cervical or endometrial cancer after pelvic radiotherapy: a cross-sectional study of vaginal measurements, risk for sexual dysfunction and quality of life

Siqueira, Thaís; Derchain, Sophie; Juliato, Cássia Raquel Teatin; Silva, Marcela Ponzio Pinto e; Machado, Helymar da Costa; Brito, Luiz Gustavo Oliveira

doi:10.1007/s00192-021-04798-8

Cited by 9 publications

(12 citation statements)

References 19 publications

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“…Vaginal stenosis as a result of radiotherapy can often lead to intractable long-term complications, loss of sexual function, pain during medical pelvic exams, predisposition to trauma and infections, and even complete vaginal occlusion [68].…”

Section: Sexuality Concernsmentioning

confidence: 99%

GCIG-Consensus guideline for Long-term survivorship in gynecologic Cancer: A position paper from the gynecologic cancer Intergroup (GCIG) symptom benefit committee

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Sehouli

Davis

et al. 2022

Cancer Treatment Reviews

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Section: Sexuality Concernsmentioning

confidence: 99%

GCIG-Consensus guideline for Long-term survivorship in gynecologic Cancer: A position paper from the gynecologic cancer Intergroup (GCIG) symptom benefit committee

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Sehouli

Davis

et al. 2022

Cancer Treatment Reviews

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“…Gynecological cancers disrupt women's sexual quality of life. However, the treatments which they receive have a greater negative effect on their sexual quality of life 7,10–12 . At the same time, the biology of cancer disrupts sexual functions and causes sexual problems for women and a decline in the sexual quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…However, the treatments which they receive have a greater negative effect on their sexual quality of life. 7,[10][11][12] At the same time, the biology of cancer disrupts sexual functions and causes sexual problems for women and a decline in the sexual quality of life. Along with this biological process, many factors such as psychological and interpersonal factors, the religious beliefs of the patient and their families, and the cultural norms of the society in which they live may affect the sexual quality of life of cancer patients.…”

Section: Linear Regression Analysis Of the Factors Associated With Se...mentioning

confidence: 99%

“…4,8,9 Most of the studies focused on the sexual dysfunctions experienced by women with gynecological cancer and the sexual quality of life of healthy women. 3,5,[10][11][12][16][17][18] In this context, this is the first study to be conducted in Türkiye on this topic. In this way, our study has shown the effect of gynecological cancers on the Turkish women's sexual quality of life in comparison with healthy women and identified predictors of sexual quality of life in Turkish women with gynecological cancer.…”

Section: Introductionmentioning

confidence: 96%

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Sexual quality of life between healthy women and women with gynecological cancer: Results of a hospital‐based case–control study in Türkiye

Ören,

Kiziltaş

2023

J of Obstet and Gynaecol

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BackgroundGynecological cancers among women were both chronic and vitally health problems. The increasing prevalence of women with surviving gynecological cancers and the receiving treatments of cancer negatively affected the sexual quality of life.AimThe study was conducted to determine the sexual quality of life of healthy women and women with gynecological cancer and to determine the predictors of sexual quality of life in women with gynecological cancer.MethodsThe research is a hospital‐based case–control study was conducted. The study was carried out with 65 patients with histologically confirmed gynecological cancer were compared with 75 controls, who were admitted to the different departments of the same hospital in the Izmir, in western Türkiye.ResultsThe Sexual Quality of Life Questionnaire score (SQOL) of cases was 60.12 ± 9.01 and controls was 78.92 ± 7.08. SQOL scores of cases were significantly lower than controls (p < 0.05). Multiple linear regression analysis results showed that age (B = −0.295, p = 0.072), working (B = 4.981, p = 0.016), smoking (B = −4.590, p = 0.035), diagnosed with cervical cancer (B = −4.214, p = 0.045), and receiving chemotherapy (B = −4.722, p = 0.028) were associated with sexual quality of life in women with gynecological cancer (p < 0.05, R2: 0.40).ConclusionWomen with gynecological cancer had lower quality of sex life compared with healthy women. Gynecological cancers negatively affect women's sexual quality of life. Health professionals (especially nurses) should be aware of the potential problems that women with gynecological cancer may experience with their sexual lives. They should develop coping strategies and offer solutions for the problems experienced by women with gynecological cancer.

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“…The addition of chemotherapy has further been proven to have a negative long-term effect on toxicity and HRQOL [ 5 ]. Furthermore, 27% of women are at risk of developing at least partial vaginal narrowing and stenosis, leading to sexual dysfunction and impaired quality of life [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial

et al. 2023

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Introduction The APROVE-trial investigated the tolerability of postoperative proton beam therapy in women with cervical or endometrial cancer. The present analysis evaluated the secondary endpoints of health-related quality of life (HRQOL) and patient-reported symptoms. Methods 25 patients were included in this prospective phase-II-trial and treated with postoperative radiotherapy using protons alone or in combination with chemotherapy. To attain general and gynecologic-specific HRQOL measures, the EORTC-QLQ-C30 questionnaires combined with -QLQ-CX24 for cervical and -QLQ-EN24 for endometrial cancer were assessed at baseline, at the end of RT and up to 2 years after radiotherapy. The results were compared to an age-matched norm reference population. Symptoms were assessed using Common Terminology Criteria for Adverse Events (CTCAE) and institutional patient-reported symptoms grading. Results Scores regarding global health status were markedly impaired at baseline (mean: 58.0 ± 20.1) compared to reference population data, but significantly (p = 0.036) improved and evened out to comparable norm values 2 years after proton therapy (mean: 69.9 ± 19.3). Treatment caused acute and long-term worsening of pain (p = 0.048) and gastrointestinal symptoms (p = 0.016) for women with endometrial cancer, but no higher-grade CTCAE ≥ 3° toxicity was observed. Dosimetric evaluation of rectum, sigmoid, large and small bowel showed no correlation with the reported gastrointestinal symptoms. After 2 years, fatigue had significantly improved (p = 0.030), whereas patients with cervical cancer experienced more often lymphedema (p = 0.017). Scores for endometrial cancer pertaining to sexual activity (p = 0.048) and body image (p = 0.022) had improved post treatment; in the latter this effect persisted after 2 years. Conclusion Proton beam therapy in the adjuvant setting was well tolerated with only low-grade side effects concerning gastrointestinal symptoms, lymphedema and pain. Overall quality of life was impaired at baseline, but patients were able to recover to values comparable to norm population 2 years after proton therapy. Larger studies are needed to confirm whether the benefit of proton therapy translates into a clinical effect. Sexual dysfunction remains an important issue. Trial registration: The trial was registered at https://clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT03184350, 09th June 2017).

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Vaginal stenosis in women with cervical or endometrial cancer after pelvic radiotherapy: a cross-sectional study of vaginal measurements, risk for sexual dysfunction and quality of life

Cited by 9 publications

References 19 publications

GCIG-Consensus guideline for Long-term survivorship in gynecologic Cancer: A position paper from the gynecologic cancer Intergroup (GCIG) symptom benefit committee

GCIG-Consensus guideline for Long-term survivorship in gynecologic Cancer: A position paper from the gynecologic cancer Intergroup (GCIG) symptom benefit committee

Sexual quality of life between healthy women and women with gynecological cancer: Results of a hospital‐based case–control study in Türkiye

Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial

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