Vaginal neuroendocrine carcinoma: regarding a clinical case

Abstract

Among the relevant gynecologic and obstetric history are: eight pregnancies (6 natural births, 1 caesarean section and 1 spontaneous abortion) and one sexual partner. She denies any previous sexually transmitted disease. She did not perform annual gynecological screening.On gynecological physical examination: an exophytic, friable and bleeding lesion of 3 cm is observed and palpated, which compromises the posterior face of the vagina, in its middle-upper third; respecting the rest of the organ and the cervix. On rectal examination, the ampulla is empty, without lesions; the parametria are free.A transvaginal pelvic ultrasound was performed in which no ovarian or uterine lesions were found. And an excisional biopsy was performed.The anatomopathological study showed: small cell neuroendocrine carcinoma. Immunohistochemistry: CK7 positive, synaptophysin positive, focal positive chromogranin, p40 negative, p16 positive and Ki67 90%.