Vaginal misoprostol for late first trimester abortion

Esteve, Josep Lluis Carbonell; Varela, L; Velazco, A.; Cabezas, Evelio; Tanda, Rika; Sánchez, Carlos

doi:10.1016/s0010-7824(98)00037-7

Cited by 40 publications

(23 citation statements)

References 13 publications

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“…[9][10][11] The data summarised here allowed clinic staff to discuss ways to modify the protocols so as better to meet the needs of women and address the concerns of providers. For example, because one in every ten women did not return for follow-up, women are now asked to return only at 15 days post-first insertion and greater emphasis is placed by staff on the importance of returning for the follow-up visits.…”

Section: Discussionmentioning

confidence: 99%

“…In most studies misoprostol is administered vaginally, as this is more effective than oral administration. [8][9][10][11][12][13][14][15][16] A number of clinical trials have sought to determine the optimal regimen for use of misoprostol alone. [17][18][19] In July 2003, an expert meeting on misoprostol was held in Washington DC, resulting in a consensus statement on use of misoprostol alone for abortion induction in pregnancies up to nine weeks (63 days) LMP.…”

Section: Introductionmentioning

confidence: 99%

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Misoprostol Alone for Early Medical Abortion in a Latin American Clinic Setting

Billings¹

2004

Reproductive Health Matters

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Misoprostol is being used widely by women throughout Latin America, often based on instructions passed along through friends, acquaintances or professionals who may have little information about safe and effective use. This paper presents the experience of a Latin American clinic working in a legally restrictive setting that offers misoprostol as one option to women seeking early pregnancy termination. Between February 2001 and June 2002, 3,225 women who attended the clinic chose to use misoprostol rather than vacuum aspiration. 89.9% returned for follow-up, of whom 76.4% had had a complete abortion within 72 hours, using one, two or three doses of 800 micrograms of misoprostol administered by the woman herself vaginally every 24 hours. The first 78 women who returned for follow-up at 72 hours responded to a questionnaire regarding their experiences. Satisfaction with the abortion process was high, despite some pain, chills, diarrhoea and/or nausea. Seventy-two of the 78 women said they would use misoprostol again if they needed to terminate another pregnancy and would recommend it to a friend. Having a clinic where staff are knowledgeable and experienced in misoprostol use is particularly important in settings where abortion is stigmatised, unsafe abortion common and access to safe services limited. A 2004 Reproductive Health Matters. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Misoprostol Alone for Early Medical Abortion in a Latin American Clinic Setting

Billings¹

2004

Reproductive Health Matters

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“…The most common adverse effects of misoprostol are nausea, vomiting, diarrhoea, abdominal pain, chills, shivering and fever. 9,10 The maximum plasma concentration is achieved more rapidly after oral than vaginal administration. However, the duration for serum concentrations to stay steady is longer when given vaginally.…”

Section: Introductionmentioning

confidence: 99%

A randomised trial of two regimens of vaginal misoprostol to manage termination of pregnancy of up to 16 weeks

Khazardoost¹,

Hantoushzadeh²,

Madani

2007

Aust NZ J Obst Gynaeco

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“…Thus, there is the pressing and important need to develop a regimen of medical abortion without mifepristone. Complete abortion rates varying from 20.0% to 93.9% have been reported with the use of misoprostol alone 5–9 . However, in most of these studies, the dosing interval of misoprostol has ranged from every 4 hours to every 48 hours.…”

Section: Introductionmentioning

confidence: 99%

A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks

Singh

Fong

Dong

2003

BJOG

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This regimen of repeated doses of vaginal misoprostol every 3 hours over a period of 9 hours, in keeping with the plasma level and pharmacokinetic of misoprostol administered vaginally, is an effective method of medical abortion that approaches the efficacy of surgical vacuum aspiration. The regimen would offer a suitable option for women requesting termination of pregnancy up to eight weeks of gestation in countries where mifespristone is and will never be made available.

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Vaginal misoprostol for late first trimester abortion

Cited by 40 publications

References 13 publications

Misoprostol Alone for Early Medical Abortion in a Latin American Clinic Setting

Misoprostol Alone for Early Medical Abortion in a Latin American Clinic Setting

A randomised trial of two regimens of vaginal misoprostol to manage termination of pregnancy of up to 16 weeks

A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks

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