Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case–control study

Tabatabaei, Negar; Eren, A. Murat; Barreiro, Luis B.; Yotova, Vania; Dumaine, Anne; Allard, Catherine; Fraser, WD

doi:10.1111/1471-0528.15299

Cited by 137 publications

(115 citation statements)

References 40 publications

(129 reference statements)

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“…In our study, we also found species of Gardnerella associated with preterm labor and short cervix. Others have shown associations between either specific taxa or vaginal CSTs and PTB [8,12,46]. The observed associations of CST IV with PTB might be explained by a higher risk for bacterial vaginosis in these women compared to women with a vaginal microbiome dominated by Lactobacillus species.…”

Section: Discussionmentioning

confidence: 89%

“…However, the positive or negative role of lactobacilli seems to be rooted on species, or even strain level. On the one hand, high abundance of certain Lactobacillus species, but on the other hand, also a generally low abundance of lactobacilli (along with bacterial vaginosis) has been associated with PTB [11] [12]. A very recent study, however, highlighted the role of an immune-system component, namely beta-defensin-2, which was found to be negatively correlated with spontaneous PTB, largely independent of the microbiome profile assessed [13].…”

mentioning

confidence: 99%

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Human Milk Oligosaccharides modulate the risk for preterm birth in a microbiome dependent and independent manner

Pausan

Kolovetsiou-Kreiner

Richter

et al. 2019

Preprint

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BackgroundPreterm birth is one of the leading causes of neonatal mortality. The causes for spontaneous preterm birth (PTB) are multifactorial and remain often unknown. In this study, we tested the hypothesis that human milk oligosaccharides (HMOs) in blood and urine modulate the maternal urinary and vaginal microbiome and influence the risk for PTB. We analyzed the vaginal and urinary microbiome of a cross-sectional cohort of women with and without preterm labor and correlated our findings with measurements of metabolites and HMOs in urine and blood. ResultsWe identified several microbial signatures associated with short cervix, PTB and/or preterm contractions such as Lactobacillus jensenii, L. gasseri, Ureaplasma sp. and Gardnerella sp..Additionally, we observed associations between sialylated HMOs, in particular 3'-sialyllactose, with PTB, short cervix and increased inflammation and confirmed an influence of HMOs on the microbiome profile. ConclusionsIdentifying serum and urinary HMOs and several key microorganisms associated with PTB, our findings point at two distinct processes modulating the risk for PTB. One process seems to be driven by sterile inflammation, characterized by increased concentrations of sialylated HMOs in serum.Another process might be microbiome-mediated, potentially driven by secretor-active HMOs in urine. Our results support current efforts to improve diagnostics and therapeutic strategies.

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Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

Human Milk Oligosaccharides modulate the risk for preterm birth in a microbiome dependent and independent manner

Pausan

Kolovetsiou-Kreiner

Richter

et al. 2019

Preprint

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“…Colonization of the female genital tract with bacterial vaginosis‐associated bacteria and decreased predominance of Lactobacillus spp. increase the risk of early preterm birth . Some lactobacillus can produce bacteriocins that have antibacterial activity against Ureaplasma spp.…”

Section: Antibiotic Regimen For Intra‐amniotic Infection With Ureaplamentioning

confidence: 99%

Current understanding and treatment of intra‐amniotic infection with Ureaplasma spp.

Tantengco

Yanagihara

2019

J of Obstet and Gynaecol

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Considerable evidence has shown that intra-amniotic infection with Ureaplasma spp. increases the risk of chorioamnionitis and preterm labor. Ureaplasma spp. are among the smallest organisms, and their isolation is uncommon in routine clinical practice because of their size and high auxotrophy. Although Ureaplasma spp. have been reported as causative agents of preterm birth, they also have a high incidence in vaginal swabs collected from healthy reproductive-age women; this has led to questions on the virulence of Ureaplasma spp. and to them being considered as harmless commensal bacteria. Therefore, many efforts have been made to clarify the pathogenicity of Ureaplasma spp. at the molecular level. Ureaplasma spp. are surrounded by lipoproteins, including multiple-banded antigen. Both multiple-banded antigen and its derivative, that is, the synthetic lipopeptide, UPM-1, induce an inflammatory response in a preterm mice model, which was adequate to cause preterm birth or stillbirth. In this review, we present an overview of the virulence mechanisms of Ureaplasma spp. and treatment of ureaplasma infection during pregnancy to prevent possible serious sequelae in infants. In addition, relevant mechanisms underlying antibiotic resistance in Ureaplasma spp. are discussed. Ureaplasma spp. are naturally resistant against β-lactam antibiotics because of the lack of a cell wall. Azithromycin is one of the effective agents that can control intrauterine ureaplasma infection. In fact, macrolide-and fluoroquinolone-resistant isolates of Ureaplasma spp. have already been observed in perinatal practice in Japan.

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“…BV word geassosieer met nadelige seksuele en repro duktiewe gesondheidsuitkomste, insluitende SOIs (Wiesenfeld et al, 2003;Gallo et al, 2012;Balkus et al, 2014) asook nadelige geboorte uitkomste (Holst, Goffeng and Andersch, 1994;Leitich and Kiss, 2007;Nelson et al, 2015). Met die ontwikkeling van 'next generation sequencing', is dit nou moontlik om spesifi eke taksa met hierdie nadelige uitkomste te assosieer, insluitende voortydige geboortes (Vinturache et al, 2016;Freitas et al, 2018;Tabatabaei et al, 2018) en MIV risiko (McClelland et al, 2018. In 'n studie wat in vyf verskillende lande (Kenya, Uganda, Suid Afrika, Tanzania, Botswana en Zambië) uitgevoer is, vind McClelland et al spesifi eke taksa wat met verhoogde MIV risiko geassosieer word in al vyf lande, met statisties betekenisvolle assosiasies met Parvimonas species tipe 1 en Gemella asaccharolytica en Mycoplasma hominis (McClelland et al, 2018).…”

Section: Inleidingunclassified

Geografiese ligging beïnvloed vaginale mikrobiese profiele in Suid-Afrikaanse vroue

Lennard¹,

Dabee²,

Barnabas³

et al. 2019

SATNT

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African women: Women of African descent are more likely to have bacterial vaginosis than women of other ethnicities. Both diversity and likely specifi c taxa in these microbial communities are important to sexual and reproductive health, such as HIV risk. However, whether the specifi c taxa also vary by geographical location and/or ethnicity requires further investigation.Here, we compare the vaginal microbiota of 16-22-year-old black, HIV-negative South African women from two geographically disparate but low-income high population density communities, one in Cape Town (CPT) and one in Johannesburg (JHB). Vaginal microbiota composition was assessed by 16S rRNA gene amplicon sequencing of lateral vaginal wall swabs.Geographical location was signifi cantly associated with vaginal microbiota composition by permutational analysis of variance (PERMANOVA) (p=0.02), as were body mass index BMI (p=0.015) and human papilloma virus (HPV) risk type (p=0.005), while the presence of one or more sexually transmitted infections (STIs) (p=0.053) and hormonal contraceptive (HC) usage (p=0.4) were not. Geographical location remained a signifi cant determinant of microbiota composition independent of BMI, STI status and HPV-risk. Together, geographical location, BMI and HPV-risk explained 10% of the variance in microbiota composition with a large proportion of the variance remaining unexplained. Several taxa differed signifi cantly between geographical location -some by frequency and others by relative abundance.Our results therefore suggest that HIV prophylactic approaches targeting the vaginal microbiota should be geographically tailored.Hoe om hierdie ar kel aan te haal:

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Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case–control study

Abstract: Largest study of its kind finds certain species of vaginal Lactobacillus + Bifidobacterium may relate to lower risk of preterm birth.

Cited by 137 publications

References 40 publications

Human Milk Oligosaccharides modulate the risk for preterm birth in a microbiome dependent and independent manner

Human Milk Oligosaccharides modulate the risk for preterm birth in a microbiome dependent and independent manner

Current understanding and treatment of intra‐amniotic infection with Ureaplasma spp.

Geografiese ligging beïnvloed vaginale mikrobiese profiele in Suid-Afrikaanse vroue

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