Vaginal Metastasis of Urothelial Carcinoma Found Incidentally during Transurethral Resection of a Bladder Tumor

Ohgaki, Kenji; Horiuchi, Kazutaka; Oka, Fumiatsu; Sato, Mitsuhiro; Nishimura, Takuya

doi:10.1272/jnms.75.312

Cited by 11 publications

(8 citation statements)

References 7 publications

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“…Another metastasis mechanism is associated with the retrograde venous blood flow from the bladder to the vagina, which is similar to the mechanism of penile metastases from bladder cancers (21,22). However, vaginal metastasis may occur via another mechanism that involves the implantation of shed tumor cells into the vagina during micturition or transurethral resection, and probably possesses a better prognosis (23). This hypothesis is consistent with the hypothesis that metastases occurs on the sites of trocar placement, surgery scars, supra pubic catheter orifices and nephrostomy tracts, and emphasizes the importance of respecting surgical oncology principles (24)(25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

“…The therapy used for these lesions is similar to that used for conventional squamous cell carcinoma, and the prognosis is challenging to establish (19). Avoiding contamination of the vagina by irrigating fluid and urine during a transurethral resection is important in order to avoid malignant cells of the bladder seeding into the vaginal wall (23).…”

Section: Discussionmentioning

confidence: 99%

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Bladder and vaginal transitional cell carcinoma: A case report

et al. 2016

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Abstract. The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC cases. The pathogenesis of vaginal TCC is challenging to determine, although it is essential for the adequate management of the tumor and to determine the appropriate treatment. The present study reports a case of bladder TCC and metachronous vaginal TCC. The patient had a history of high risk non muscle invasive bladder cancer treated by BCG and presented with a recurrent carcinoma in situ. A novel cycle of BCG was initiated but the patient had a persistent disease and a palpable mass on bimanual examination. Radical anterior pelvectomy and bilateral pelvic and inguinal lymph node dissection was performed revealing the presence of TCC of the bladder neck and the invasion into the anterior vaginal wall. The differences between local vaginal invasion and the metastatic spread from a primary bladder TCC, the occurrence of a second primary vaginal tumor and the direct implantation of TCC via urine that contains transitional cancer cells were reviewed and analyzed. Finally, a management plan was determined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bladder and vaginal transitional cell carcinoma: A case report

et al. 2016

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“…External and internal radiation therapy is the most frequently used treatment in the literature [4]. The second involves treating the lesion as a resectable metastasis [5]. Of the 15 cases reported in the literature, there were 11 endoscopic resections, two hysterovaginectomies and only two surgical resections [5].…”

Section: Discussionmentioning

confidence: 99%

Isolated vaginal metastasis from rectal adenocarcinoma: a rare presentation

et al. 2011

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A 62-year-old female was diagnosed with adenocarcinoma of the upper rectum. At the time of the assessment, she was suffering from metrorrhagia. A gynaecological examination revealed a posterior, low vaginal lesion that was remote from the lower pole of the rectal tumour. Biopsies showed that the rectal and vaginal lesions were the same. However, the vaginal lesion was not detected by magnetic resonance imaging (MRI). At the same time as resection of the high rectum lesion, local excision of the vaginal lesion (0.8 · 1.2 cm, with 1 cm margins) was performed. The patient received FOLFIRI as adjuvant irinotecan-based chemotherapy. There was no recurrence 1 year after surgery.

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“…These include a primary UC originating from the vagina, direct invasion of a bladder UC [20,21], metastasis from a bladder UC, and implantation via urine in a urinary tract UC. Seven cases were considered to be implantation by irrigation fluid of transurethral resection or transfer of urine [8,9,14,[16][17][18][19]. Many of these cases were non-muscle invasive urinary tract UC that had a low likelihood of distant metastasis and had a history of frequent endoscopic procedures or intravesical injection therapies.…”

Section: Discussionmentioning

confidence: 99%

“…They most likely occur because of the close relationship between the urothelium and Mullerian-type epithelium in embryological development [2,3]. UCs of the ovary [2], the fallopian tube [4], the endometrium [5], the cervix [3], and the vagina [6][7][8][9][10][11][12][13][14][15][16][17][18][19] have been reported. Herein we report a case of non-muscle invasive bladder carcinoma with concomitant vaginal UC.…”

Section: Introductionmentioning

confidence: 99%

Non-muscle invasive bladder cancer with concomitant vaginal urothelial carcinoma: a case report and review of the literature

et al. 2010

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A 74-year-old female was referred to our hospital for non-muscle invasive bladder tumors initially treated at another hospital. Preoperatively, computed tomography and magnetic resonance imaging demonstrated non-muscle invasive bladder tumors and a vaginal tumor. A second transurethral resection of the bladder tumors, transvaginal tumor resection, and systemic chemotherapy were performed. The histopathological appearances of both tumors were very similar and the diagnoses were urothelial carcinoma (UC). The pathogenesis of the vaginal UC was considered to be the primary UC or metastasis from the bladder UC. Vaginal UC is extremely rare and this is only the 15th report in the literature.

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Vaginal Metastasis of Urothelial Carcinoma Found Incidentally during Transurethral Resection of a Bladder Tumor

Cited by 11 publications

References 7 publications

Bladder and vaginal transitional cell carcinoma: A case report

Bladder and vaginal transitional cell carcinoma: A case report

Isolated vaginal metastasis from rectal adenocarcinoma: a rare presentation

Non-muscle invasive bladder cancer with concomitant vaginal urothelial carcinoma: a case report and review of the literature

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