Vaginal involvement in endometrial carcinoma

Price, Joseph J.; Hahn, George A.; Rominger, Christian

doi:10.1016/0002-9378(65)90702-7

Cited by 71 publications

(4 citation statements)

References 8 publications

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“…On the other hand G3 patients, in whom a high mortality has been observed as opposed to a low rate of local or distant metastases, were probably prone to a rather fast disease progression, in which only the final stage of the evolution, death, was unfortunately detected. Factors associated with the high grade histological variant that may have a bearing on prognosis include a tendency for higher mean age at diagnosis, a greater incidence of both deep myometrial invasion and lymph node involvement [3], and a high risk of clinical understaging as well as a higher rate of vaginal recurrences [4]. Age at diagnosis did not appear as a significant prognostic factor, though for both OS and DFS the estimated HRs showed a trend in the expected direction.…”

Section: Overall Survival Analysismentioning

confidence: 90%

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Effect of grade on disease-free survival and overall survival in FIGO stage I adenocarcinoma of the endometrium

Delaloye

Pampallona²,

Coucke

et al. 2000

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods: From 1979 to 1995, 350 patients with FIGO stage IA-IC with well (G1), moderately (G2) or poorly (G3) differentiated tumors were treated with surgery and high dose-rate brachytherapy with or without external radiation. Median age was 65 years (39-86 years). Results: The 5-year DFS was 8863% for the G1 tumors, 7764% for the G2 tumors, and 6767% for the G3 tumors (P50.0049). With regard to the events contributing to DFS, the 5-year cumulative percentage of local relapse was 4.6% for the G1 tumors, 9.0% for the G2 tumors, and 4.6% (P50.027) for the G3 tumors. Cumulative percentage of metastasis was 1.4, 6.3 and 7.2% (P,0.001), respectively, whereas percentages of death were 6.0, 7.9 and 20.7% (P,0.001). The 5-year OS was 9163, 8364 and 7667%, respectively (P50.0018). In terms of multivariate hazard ratios (HR), the relative differences between the three differentiation groups correspond to an increase of 77% of the risk of occurrence of either of the three events considered for the DFS (HR51.77,), (P50.078) for the G2 tumors and of 163% (HR52.63,), (P50.009) for the G3 tumors with respect to the G1 tumors. The estimated relative hazards for OS are, respectively, in line with those for DFS: HR51.51 (P50.282) for the G2 tumors; and HR53.37 (P50.003) for the G3 tumors. Conclusion: Patients with grade 1 tumors are those least exposed to either local relapse, metastasis, or death. In contrast patients with grade 2 tumors seem to be at higher risk of metastasis, whereas patients with grade 3 tumors appear at higher risk of death. Since we have looked at the first of three competing events (local relapse, metastasis and death), this suggests that patients with grade 3 tumors probably progress to death so fast that local relapse, if any, cannot be observed.

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Section: Overall Survival Analysismentioning

confidence: 90%

“…Cell differentiation has been shown to be one of the most important prognostic factors in carcinoma of the endometrium [1][2][3][4]. In this retrospective analysis we 2.…”

Section: Introductionmentioning

confidence: 99%

Effect of grade on disease-free survival and overall survival in FIGO stage I adenocarcinoma of the endometrium

Delaloye

Pampallona²,

Coucke

et al. 2000

European Journal of Obstetrics & Gynecology and Reproductiv

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“…This procedure reduces the incidence of recurrence from 12 to 3 or 4 % ( 3 , 16, 24,28). In late cases with advanced changes, management is more difficult.…”

Section: -30)mentioning

confidence: 99%

Efficacy of Primary Radiation in Carcinoma of the Endometrium: Preliminary Study of Unselected Material from a Specific Region in the North of Sweden

Kjellgren

Magnússon

1970

Acta Radiologica: Therapy, Physics, Biology

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“…Vaginal recurrences are reported in up to 18% of patients with endometrial cancer confined to the uterus treated with hysterectomy alone (1)(2)(3)(4)(5). Tumor dimension, stromal invasion, lymphovascular space involvement, age, and grade are the most relevant factors determining local treatment failure (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 98%

Postoperative Intensity-Modulated Radiotherapy in Low-Risk Endometrial Cancers: Final Results of a Phase I Study

Macchia¹,

Cilla

Ferrandina³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Vaginal involvement in endometrial carcinoma

Cited by 71 publications

References 8 publications

Effect of grade on disease-free survival and overall survival in FIGO stage I adenocarcinoma of the endometrium

Effect of grade on disease-free survival and overall survival in FIGO stage I adenocarcinoma of the endometrium

Efficacy of Primary Radiation in Carcinoma of the Endometrium: Preliminary Study of Unselected Material from a Specific Region in the North of Sweden

Postoperative Intensity-Modulated Radiotherapy in Low-Risk Endometrial Cancers: Final Results of a Phase I Study

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