Vaginal implantation metastasis of endometrial carcinoma: A case report

Wang, Yueling; Du, Jiang; Lv, Shulan; Sui, Yanxia; Xue, Xue; Sun, Chao; Zou, Junkai; Ma, Qunying; Fu, Guoxing; Song, Qing; Li, Qiling

doi:10.3892/ol.2016.4656

Cited by 6 publications

(7 citation statements)

References 6 publications

(7 reference statements)

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“…Wang Y et al, believed that their case resulted from the shedding of cancer cells during examination or surgery. 6 Hisamoto K et al, believed that the vaginal lesion in their case have been implanted through trans-vaginal uterine removal during the laparoscopic surgery. 7 This case probably also resulted from shedding of cancer cells during examination or surgery.…”

Section: Discussionmentioning

confidence: 97%

“…9 Some authors advocate cervical cerclage, ligation of the fallopian tubes and vaginal douching to prevent carcinoma cells from implanting in other organs. 6 Reducing unnecessary gynaecological examinations is expected to lower the possibility of cancer cell dissemination. 8 Further research should be carried out to establish the actual mechanisms of vaginal implantation metastasis of cases of endometrial carcinoma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Endometrial cancer with implantation metastasis to vagina: a case report

Sapiee

Abas

Ramli

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Authors present a case of vaginal implantation metastasis following a diagnosis of endometrial cancer. A 58-year-old lady presented with postmenopausal bleeding and was later diagnosed to have endometrial cancer. She underwent an extra-fascial hysterectomy and bilateral salpingo-oophrorectomy with pelvic lymphadenectomy for Stage 3A endometrioid adenocarcinoma of the endometrium. The lymph nodes and cervix were free from the disease and no lymphovascular invasion was seen on the pathological specimen. She defaulted adjuvant radiotherapy and was lost to follow up. Six months later she had a tumour recurrence at the vaginal introitus just below the urethral orifice and awal from the vaginal vault with similar histopathological findings as previous cancer. This case highlights the rare occurrence of implantation metastasis of endometrial cancer.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Endometrial cancer with implantation metastasis to vagina: a case report

Sapiee

Abas

Ramli

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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show abstract

“…In one study, of the 176 patients who underwent endometrial curettage before hysterectomy, 9 (5.1%) were found to have cervical implantation metastasis [ 33 ]. Moreover, endometrial carcinomas are well known to have an implantation capacity, which is the ability of tumor cells detached from the primary endometrial tumor to migrate to the peritoneal cavity through the fallopian tubes for implantation on the peritoneal surface, resulting in peritoneal, cervical, or vaginal implantation [ 34 ]. In a study by Stewart et al [ 32 ], tumor cell emboli within the tubal lumina were identified in 26% and 3% of high- and low-grade endometrial carcinomas, respectively.…”

Section: Discussionmentioning

confidence: 99%

Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses

2022

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While synchronous ovarian and endometrial endometrioid carcinomas (ECs) have long been described in the literature, ovarian or endometrial EC involving concomitant endocervical polyp (ECP) has not yet been reported. This study aimed to investigate the histological types and prevalence of gynecological tumors co-existing with ECP and to comprehensively analyze the clinicopathological characteristics of ovarian and endometrial ECs involving ECPs. We searched for ECP cases associated with premalignant lesions or malignancies of the female genital tract occurring between March 2019 and February 2022. We then investigated the histological types and prevalence of gynecological tumors co-existing with ECP. In addition, we reviewed electronic medical records and pathology slides to collect the clinicopathological features of four patients with ovarian or endometrial EC involving ECP. We found 429 ECPs over the three-year study period. Of these, 68 (15.9%) were associated with premalignant or malignant lesions occurring in the uterine cervix, endometrium, and ovaries. Four of these cases, including two (0.5%) ovarian grade 3 ECs and two (0.5%) endometrial grade 1 ECs, involved ECPs. In the former cases (cases 1 and 2), ECs involving ECPs exhibited similar morphology and immunohistochemical staining results to those of advanced-stage ovarian EC. In the latter cases (cases 3 and 4), the histological and immunophenotypical features of EC involving ECP were identical to those of primary endometrial EC, despite the lack of tumor involvement in the myometrium, lower uterine segment, and cervical stroma as well as the absence of lymphovascular invasion and lymph node metastasis. In all cases, no evidence of benign endometriosis, endometrial hyperplasia without atypia, or atypical hyperplasia/endometrial intraepithelial neoplasm within ECP or the adjacent endocervical tissue was noted. Considering our results, the involvement of ECP by EC may have been caused by an implantation metastasis from the ovarian (cases 1 and 2) or endometrial (cases 3 and 4) EC. To the best of our knowledge, this is the first exploration of the synchronous occurrence of endometrial or ovarian EC and ECP involvement. Implantation metastasis via transtubal and trans-endometrial cavity migration may have been the pathogenic mechanism of ECP involvement.

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“…Endometrial carcinoma is the fourth [1] most common malignancy in women worldwide and represents the most common gynaecological cancer in developed countries. The three common spread patterns of endometrial cancer are local invasion, lymphatic spread and hematogenous spread [2]. The most common sites of metastatic disease are pelvic and para-aortic lymph nodes, usually present in the context of deep myometrial invasion (present in 46% of those cases, compared to 3% when only superficial myometrial invasion occurs) [3].…”

Section: Discussionmentioning

confidence: 99%

Value of magnetic resonance imaging in identifying mucosal urinary bladder metastasis from endometrial carcinomas: a case report

Pissarra¹,

Cunha²,

Ramos³

et al. 2021

Journal of Molecular and Clinical Medicine

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A 73-year-old female patient with no relevant past medical history presented with post-menopausal vaginal bleeding. The patient underwent a hysteroscopy with endometrial biopsy revealing a poorly differentiated endometrial serous carcinoma. MRI staging depicted para-aortic lymph nodes and peritoneal metastases in the left upper quadrant. There were no signs of invasion of the outer half of the myometrium. Two polypoid lesions were identified in the posterior wall of the bladder and a confirmatory cystoscopy was recommended. Those lesions were later confirmed to be metastases of endometrial origin. Non-contiguous metastases to mucosal urinary bladder from endometrial carcinoma can occur and, as depicted in our case, can be well identified with magnetic resonance imaging.

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Vaginal implantation metastasis of endometrial carcinoma: A case report

Cited by 6 publications

References 6 publications

Endometrial cancer with implantation metastasis to vagina: a case report

Endometrial cancer with implantation metastasis to vagina: a case report

Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses

Value of magnetic resonance imaging in identifying mucosal urinary bladder metastasis from endometrial carcinomas: a case report

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