Vaginal CO2 laser for the treatment of vulvovaginal atrophy in women with breast cancer: LAAVA pilot study

Pearson, A. Scott; Booker, Andrew; Tio, Martin; Marx, Gavin

doi:10.1007/s10549-019-05384-9

Cited by 46 publications

(72 citation statements)

References 13 publications

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“…After reviewing the full‐text articles, an additional 20 records were excluded. This process resulted in 49 articles, 1,2,4,13‐58 which were further reviewed using a hand‐searching approach. Table 2 displays all the selected studies.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 displays all the selected studies. Of these, 37 were about the CO 2 laser, 1,2,4,13,14,17‐19,22‐27,29‐31,33‐37,39,42,45‐47,49‐58 10 were about the Erbium laser, 15,16,20,32,38,40,41,43,44,48 and two were about radiofrequency 21,28 . Outcomes of the studies included in the systematic review are shown in Table 3.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In the 37 studies on the CO 2 laser, 1,2,4,13,14,17‐19,22‐27,29‐31,33‐37,39,42,45‐47,49‐58 a total of 2513 women were included (mean age 55.04 years). A total of 22 studies were prospective, 2,13,14,17,18,22,24,26,27,29,30,33,35‐37,39,42,46,49,53,55,57 six were retrospective, 4,23,34,45,50,51 five were cohort, 19,25,47,54,58 and four were randomized clinical trials 1,31,52,56 . Most of these studies were conducted in Italy ( n = 13) 13,14,17,18,22‐25,35,37,45,50,51 followed by the USA ( n = 7), 19,27,36,39,46,52,57 Greece ( n = 4), 4,26,29,34 Brazil ( n = 3), 1,31,56 Hungary ( n = 3), 49,54,58 Iran ( n = 2), 2,42 Colombia ( n = 1), 33 Spain ( n = 1), 30 Singapore ( n = 1), 47 Australia ( n = 1), 53 and Peru ( n = 1) 55 …”

Section: Resultsmentioning

confidence: 99%

“…All the treatment protocols in these studies involved three sessions of laser 1,2,4,13,14,17‐19,22‐27,29‐31,33‐37,39,42,45‐47,49‐58 ; however, the interval between sessions varied from 30 days 1,4,13,14,17,22‐25,28,29,33‐35,37,42,45‐47,51,55‐57 to 4 and 6 weeks, 2,18,19,27,30,31,36,39,49,52‐54,58 and one study did not specify this data 50 . The assessment of outcomes were in the range of 0–24 weeks and 0–36 months after laser treatment.…”

Section: Resultsmentioning

confidence: 99%

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Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Sarmento

Lírio

Medeiros

et al. 2021

Intl J Gynecology & Obste

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Background Genitourinary syndrome of menopause (GSM) negatively affects sexual function and quality of life. Techniques like laser and radiofrequency are being used to manage GSM, particularly in women with contraindications for hormone therapy. Objectives To verify whether the physical methods of laser and radiofrequency can be recommended as safe and effective options for the treatment of GSM/urinary urgency or incontinence in pre‐ and postmenopausal women. Search strategy Databases were comprehensively searched using combinations of the following keywords in any language: “postmenopause”; “genitourinary syndrome of menopause”; “vaginal atrophy”; “radiofrequency”; and “laser.” Selection criteria Full articles of case‐control, cross‐sectional, cohort, randomized clinical trials, and quasi‐randomized or controlled clinical trials were included. Data collection and analysis All authors independently evaluated the design of the studies for quality of reporting, risk of bias, and quality of evidence. Main results Of the included 49 studies, 37 were on the CO2 laser, 10 on the Erbium laser, and two on radiofrequency. Conclusions Laser and radiofrequency therapy could be promising and safe therapeutic options for GSM/urinary incontinence. However, the study findings cannot be generalized until new randomized clinical trials are performed that confirm the strength of the evidence. This review has been registered with PROSPERO: CRD42020141913.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Sarmento

Lírio

Medeiros

et al. 2021

Intl J Gynecology & Obste

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Efficacy of CO₂ laser treatment in postmenopausal women with vulvovaginal atrophy: A meta‐analysis

Liu

Zhou

et al. 2021

Intl J Gynecology & Obste

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Objective: To explore the efficacy of CO 2 laser treatment in postmenopausal women with vulvovaginal atrophy.Method: PubMed, Embase, Cochrane Library and Web of Science were searched to June 9, 2020. Prospective studies on the efficacy of CO 2 laser treatment were included. Two researchers independently reviewed articles and extracted data.Heterogeneity test was conducted for each outcome indicator. Sensitivity analysis was performed in all models.Results: Twelve articles including 459 participants were enrolled. Compared with baseline, vaginal health indeices (VHIs) were significantly higher at the 1-, 3-, 6-, and 12-month follow ups (P < 0.001). For VVA severity, the visual analog scale scores for vaginal dryness at 1-, 3-, 6-, and 12-month follow-ups (P < 0.050), vaginal burning, itching, and dysuria at 1-month follow up (P < 0.001), and dyspareunia at 1-, 3-, 6-, and 12-month follow-ups (P < 0.001) were all significantly lower. For FSFI, total scores at 1-, 3-, 6-, and 12-month follow ups (P < 0.001), and the scores in desire, arousal, lubrication, orgasm, satisfaction, and pain at 1-month follow up (P < 0.050) were all significantly higher. For quality of life, the PCS12 and MCS12 scores were all significantly higher (P < 0.050) at the 1-month follow up. Conclusion:CO 2 laser treatment may be effective for postmenopausal women with VVA symptoms in improving quality of life and sexual function.

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Nachsorge nach Mammakarzinomerkrankung

Heilmann

Maass

2020

Gynäkologe

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Vaginal CO2 laser for the treatment of vulvovaginal atrophy in women with breast cancer: LAAVA pilot study

Cited by 46 publications

References 13 publications

Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Efficacy of CO₂ laser treatment in postmenopausal women with vulvovaginal atrophy: A meta‐analysis

Nachsorge nach Mammakarzinomerkrankung

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Vaginal CO2 laser for the treatment of vulvovaginal atrophy in women with breast cancer: LAAVA pilot study

Cited by 46 publications

References 13 publications

Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Physical methods for the treatment of genitourinary syndrome of menopause: A systematic review

Efficacy of CO2 laser treatment in postmenopausal women with vulvovaginal atrophy: A meta‐analysis

Nachsorge nach Mammakarzinomerkrankung

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Efficacy of CO₂ laser treatment in postmenopausal women with vulvovaginal atrophy: A meta‐analysis